JP7771049B2 - 新化合物 - Google Patents

新化合物

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Publication number
JP7771049B2
JP7771049B2 JP2022516299A JP2022516299A JP7771049B2 JP 7771049 B2 JP7771049 B2 JP 7771049B2 JP 2022516299 A JP2022516299 A JP 2022516299A JP 2022516299 A JP2022516299 A JP 2022516299A JP 7771049 B2 JP7771049 B2 JP 7771049B2
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JP
Japan
Prior art keywords
methyl
imidazol
urea
phenyl
thienylsulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022516299A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022549086A (ja
JP2022549086A5 (https=
Inventor
フェックス，トマス
オルソン，ベンクト
Original Assignee
ヴィコール ファルマ アーベー
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Filing date
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Application filed by ヴィコール ファルマ アーベー filed Critical ヴィコール ファルマ アーベー
Publication of JP2022549086A publication Critical patent/JP2022549086A/ja
Publication of JP2022549086A5 publication Critical patent/JP2022549086A5/ja
Priority to JP2025186669A priority Critical patent/JP2026041728A/ja
Application granted granted Critical
Publication of JP7771049B2 publication Critical patent/JP7771049B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022516299A 2019-09-20 2020-09-18 新化合物 Active JP7771049B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025186669A JP2026041728A (ja) 2019-09-20 2025-11-05 新化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1913603.5 2019-09-20
GB201913603A GB201913603D0 (en) 2019-09-20 2019-09-20 New compounds
PCT/GB2020/052261 WO2021053344A1 (en) 2019-09-20 2020-09-18 New compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025186669A Division JP2026041728A (ja) 2019-09-20 2025-11-05 新化合物

Publications (3)

Publication Number Publication Date
JP2022549086A JP2022549086A (ja) 2022-11-24
JP2022549086A5 JP2022549086A5 (https=) 2023-09-06
JP7771049B2 true JP7771049B2 (ja) 2025-11-17

Family

ID=68425648

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022516299A Active JP7771049B2 (ja) 2019-09-20 2020-09-18 新化合物
JP2025186669A Pending JP2026041728A (ja) 2019-09-20 2025-11-05 新化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025186669A Pending JP2026041728A (ja) 2019-09-20 2025-11-05 新化合物

Country Status (15)

Country Link
US (2) US12435072B2 (https=)
EP (1) EP4031240A1 (https=)
JP (2) JP7771049B2 (https=)
KR (1) KR20220101071A (https=)
CN (1) CN114786774A (https=)
AU (1) AU2020351301B2 (https=)
BR (1) BR112022003130A2 (https=)
CA (1) CA3152218A1 (https=)
CL (1) CL2022000656A1 (https=)
CO (1) CO2022003091A2 (https=)
GB (1) GB201913603D0 (https=)
IL (1) IL291172A (https=)
MX (2) MX2022003286A (https=)
PH (1) PH12022550564A1 (https=)
WO (1) WO2021053344A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202004094D0 (en) * 2020-03-20 2020-05-06 Vicore Pharma Ab New compounds and uses
GB202013721D0 (en) * 2020-09-01 2020-10-14 Vicore Pharma Ab New compounds
GB202104033D0 (en) * 2021-03-23 2021-05-05 Vicore Pharma Ab New compounds
CA3212900A1 (en) * 2021-03-23 2022-09-29 Tomas Fex Selective angiotensin ii receptor ligands
GB202104038D0 (en) * 2021-03-23 2021-05-05 Vicore Pharma Ab New compounds
GB2605148A (en) * 2021-03-23 2022-09-28 Vicore Pharma Ab New compounds
GB202113583D0 (en) * 2021-09-23 2021-11-10 Vicore Pharma Ab New compounds
KR20240035402A (ko) 2021-07-09 2024-03-15 바이코어 파마 아베 신규의 선택적 안지오텐신 ii 화합물
US20250214978A1 (en) * 2022-04-06 2025-07-03 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company At2r agonist
IE20230600A3 (en) 2022-12-22 2025-09-24 Vicore Pharma Ab A method of treating a patient diagnosed with an interstitial lung disease
EP4648850A1 (en) * 2023-01-09 2025-11-19 Vicore Pharma AB Selective angiotensin ii compounds
AU2024331772A1 (en) * 2023-08-25 2026-04-02 Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. Thienylsulfonyl carbamates as at2r agonists
CN120247885A (zh) * 2024-01-03 2025-07-04 武汉人福创新药物研发中心有限公司 一种并环类化合物作为at2r激动剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068226A1 (de) 1999-05-05 2000-11-16 Aventis Pharma Deutschland Gmbh 1-(p-thienylbenzyl)-imidazole als agonisten von angiotensin-(1-7)-rezeptoren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
JP2004533457A (ja) 2001-05-31 2004-11-04 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
JP2008535898A (ja) 2005-04-12 2008-09-04 ヴィコール・ファルマ・アーベー 新規な三環系アンジオテンシンｉｉアゴニスト
JP2015504870A (ja) 2011-12-16 2015-02-16 タリックス ファーマシューティカルズ リミテッド 線維症を処置するためのアンジオテンシン
JP2018507244A (ja) 2015-03-02 2018-03-15 ビーコレ ファルマ アクティエボラーグ 肺線維症の治療のためのアンギオテンシンｉｉ受容体作動薬
JP2019519586A (ja) 2016-06-29 2019-07-11 ユニヴェルシテ・ドゥ・モントリオール ビアリールメチルヘテロサイクル

Family Cites Families (14)

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US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5312820A (en) 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
US5444067A (en) 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
SE9800550D0 (sv) 1998-02-24 1998-02-24 A & Science Invest Ab A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof
DE19920815A1 (de) 1999-05-05 2000-11-09 Aventis Pharma Gmbh 1-(p-Thienylbenzyl)-Imidazole als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1529697B (zh) 2001-05-31 2010-09-22 维科尔药物公司 用作血管紧张素ⅱ激动剂的三环化合物
AU2003302106A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
US8835471B2 (en) 2010-06-11 2014-09-16 Vicore Pharma Ab Use of angiotensin II agonists
EP3935944A1 (en) 2013-03-15 2022-01-12 University Of Southern California, USC Stevens Compounds for the treatment of musculoskeletal diseases
EP2832357A1 (en) 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selective AT2 receptor agonists for use in treatment of cachexia
BR112017012337A2 (pt) 2014-12-12 2018-02-27 Vicore Pharma Ab Método para tratamento de doença falciforme, agonista do receptor at2, ou um sal farmaceuticamente aceitável, solvato ou pró- fármaco do mesmo, uso de um agonista do receptor at2, ou um sal farmaceuticamente aceitável, solvato ou pró-fármaco do mesmo, formulação farmacêutica, e, produto de combinação.
WO2016107879A2 (en) 2014-12-30 2016-07-07 Vicore Pharma Ab New use of angiotensin ii receptor agonists
WO2017221012A1 (en) 2016-06-21 2017-12-28 Vicore Pharma Ab Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity
GB201710906D0 (en) 2017-07-06 2017-08-23 Vicore Pharma Ab Compounds and methods for treating peripheral neuropathy

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068226A1 (de) 1999-05-05 2000-11-16 Aventis Pharma Deutschland Gmbh 1-(p-thienylbenzyl)-imidazole als agonisten von angiotensin-(1-7)-rezeptoren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
JP2002544130A (ja) 1999-05-05 2002-12-24 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アンギオテンシン（１−７）受容体のアゴニストとしての１−（ｐ−チエニルベンジル）イミダゾール、その製造方法、その使用およびそれらを包含する医薬製剤
JP2004533457A (ja) 2001-05-31 2004-11-04 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
JP2008535898A (ja) 2005-04-12 2008-09-04 ヴィコール・ファルマ・アーベー 新規な三環系アンジオテンシンｉｉアゴニスト
JP2015504870A (ja) 2011-12-16 2015-02-16 タリックス ファーマシューティカルズ リミテッド 線維症を処置するためのアンジオテンシン
JP2018507244A (ja) 2015-03-02 2018-03-15 ビーコレ ファルマ アクティエボラーグ 肺線維症の治療のためのアンギオテンシンｉｉ受容体作動薬
JP2019519586A (ja) 2016-06-29 2019-07-11 ユニヴェルシテ・ドゥ・モントリオール ビアリールメチルヘテロサイクル

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Anuradha Pandey et al.，AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy，European Journal of Pharmacology，2017年，815，251-257，DOI: 10.1016/j.ejphar.2017.09.036
Xiongyu Wu et al.，Selective Angiotensin II AT2 Receptor Agonists: Arylbenzylimidazole Structure-Activity Relationships，J. Med. Chem.，2006年，49，7160-7168，DOI: 10.1021/jm0606185

Also Published As

Publication number Publication date
CN114786774A (zh) 2022-07-22
AU2020351301A1 (en) 2022-03-17
CA3152218A1 (en) 2021-03-25
JP2022549086A (ja) 2022-11-24
JP2026041728A (ja) 2026-03-10
US20220388994A1 (en) 2022-12-08
KR20220101071A (ko) 2022-07-19
US20260028333A1 (en) 2026-01-29
CO2022003091A2 (es) 2022-04-19
WO2021053344A1 (en) 2021-03-25
PH12022550564A1 (en) 2023-03-20
MX2022003286A (es) 2022-04-12
BR112022003130A2 (pt) 2022-05-17
CL2022000656A1 (es) 2022-11-04
EP4031240A1 (en) 2022-07-27
MX2025000262A (es) 2025-02-10
GB201913603D0 (en) 2019-11-06
AU2020351301B2 (en) 2026-02-12
IL291172A (en) 2022-05-01
US12435072B2 (en) 2025-10-07

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