JP7765291B2 - Ｃｄ３３標的免疫療法 - Google Patents

Ｃｄ３３標的免疫療法

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Publication number
JP7765291B2
JP7765291B2 JP2021566152A JP2021566152A JP7765291B2 JP 7765291 B2 JP7765291 B2 JP 7765291B2 JP 2021566152 A JP2021566152 A JP 2021566152A JP 2021566152 A JP2021566152 A JP 2021566152A JP 7765291 B2 JP7765291 B2 JP 7765291B2
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JP
Japan
Prior art keywords
cell
cells
polypeptide
domain
vhh
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Japanese (ja)
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JP2022531719A (ja
JPWO2020227474A5 (enExample
Inventor
ジョーダン ジャージョル，
マーク ポグソン，
ワイ－ハン レオン，
カイル ジョーンズ，
ウィリアム クラゴ，
アンジェリカ サナブリア，
アンドリュー ホランズ，
ジェイコブ ガノ，
ミルトン マ，
ジョン シー． ティマー，
ブレンダン ピー． エクケルマン，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2022531719A publication Critical patent/JP2022531719A/ja
Publication of JPWO2020227474A5 publication Critical patent/JPWO2020227474A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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JP2021566152A 2019-05-08 2020-05-07 Ｃｄ３３標的免疫療法 Active JP7765291B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962845304P 2019-05-08 2019-05-08
US62/845,304 2019-05-08
US201962898392P 2019-09-10 2019-09-10
US62/898,392 2019-09-10
PCT/US2020/031780 WO2020227474A1 (en) 2019-05-08 2020-05-07 Cd33 targeted immunotherapies

Publications (3)

Publication Number Publication Date
JP2022531719A JP2022531719A (ja) 2022-07-08
JPWO2020227474A5 JPWO2020227474A5 (enExample) 2023-06-23
JP7765291B2 true JP7765291B2 (ja) 2025-11-06

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JP2021566152A Active JP7765291B2 (ja) 2019-05-08 2020-05-07 Ｃｄ３３標的免疫療法

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US (1) US20220324942A1 (enExample)
EP (1) EP3966251A4 (enExample)
JP (1) JP7765291B2 (enExample)
KR (1) KR20220031554A (enExample)
CN (1) CN114206928B (enExample)
AU (1) AU2020268379A1 (enExample)
BR (1) BR112021022356A2 (enExample)
CA (1) CA3139096A1 (enExample)
IL (1) IL287770A (enExample)
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MX (1) MX2021013591A (enExample)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12291560B2 (en) 2018-12-14 2025-05-06 Regeneron Pharmaceuticals, Inc. Dimerizing agent regulated immunoreceptor complexes
CN116867806A (zh) * 2021-02-10 2023-10-10 先声再明医药有限公司 人cd33抗体及其用途
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