CA3139096A1 - Cd33 targeted immunotherapies - Google Patents

Cd33 targeted immunotherapies Download PDF

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Publication number
CA3139096A1
CA3139096A1 CA3139096A CA3139096A CA3139096A1 CA 3139096 A1 CA3139096 A1 CA 3139096A1 CA 3139096 A CA3139096 A CA 3139096A CA 3139096 A CA3139096 A CA 3139096A CA 3139096 A1 CA3139096 A1 CA 3139096A1
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CA
Canada
Prior art keywords
cell
polypeptide
domain
cells
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3139096A
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English (en)
French (fr)
Inventor
Jordan JARJOUR
Mark POGSON
Wai-Hang LEUNG
Kyle Jones
William Crago
Angelica SANABRIA
Andrew HOLLANDS
Jacob GANO
Milton MA
John C. Timmer
Brendan P. Eckelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inhibrx Inc
2Seventy Bio Inc
Original Assignee
Inhibrx Inc
2Seventy Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc, 2Seventy Bio Inc filed Critical Inhibrx Inc
Publication of CA3139096A1 publication Critical patent/CA3139096A1/en
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/90—Isomerases (5.)
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    • C12Y—ENZYMES
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CA3139096A 2019-05-08 2020-05-07 Cd33 targeted immunotherapies Pending CA3139096A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962845304P 2019-05-08 2019-05-08
US62/845,304 2019-05-08
US201962898392P 2019-09-10 2019-09-10
US62/898,392 2019-09-10
PCT/US2020/031780 WO2020227474A1 (en) 2019-05-08 2020-05-07 Cd33 targeted immunotherapies

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CA3139096A1 true CA3139096A1 (en) 2020-11-12

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CA3139096A Pending CA3139096A1 (en) 2019-05-08 2020-05-07 Cd33 targeted immunotherapies

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US (1) US20220324942A1 (enExample)
EP (1) EP3966251A4 (enExample)
JP (1) JP7765291B2 (enExample)
KR (1) KR20220031554A (enExample)
CN (1) CN114206928B (enExample)
AU (1) AU2020268379A1 (enExample)
BR (1) BR112021022356A2 (enExample)
CA (1) CA3139096A1 (enExample)
IL (1) IL287770A (enExample)
MA (1) MA55907A (enExample)
MX (1) MX2021013591A (enExample)
SG (1) SG11202111890RA (enExample)
WO (1) WO2020227474A1 (enExample)

Families Citing this family (6)

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WO2020123947A1 (en) 2018-12-14 2020-06-18 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
WO2022171113A1 (zh) * 2021-02-10 2022-08-18 江苏先声药业有限公司 人cd33抗体及其用途
CA3240542A1 (en) * 2021-12-10 2023-06-15 Jacob S. APPELBAUM Methods and compositions for modulating the activity of a dimerizing agent regulated immunomodulatory complex
IL316032A (en) * 2022-04-08 2024-11-01 Regeneron Pharma Multicomponent receptor and signaling complexes
EP4511394A2 (en) * 2022-04-22 2025-02-26 Inhibrx Biosciences, Inc. Siglec-8 binding proteins and uses thereof
CN119585438A (zh) 2022-05-26 2025-03-07 再生元制药公司 用于维持慢病毒载体的组合物及其用途

Family Cites Families (16)

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US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
CA2956667A1 (en) * 2013-07-29 2015-02-05 Bluebird Bio, Inc. Multipartite signaling proteins and uses thereof
WO2015142661A1 (en) * 2014-03-15 2015-09-24 Novartis Ag Regulatable chimeric antigen receptor
JP6673848B2 (ja) * 2014-04-03 2020-03-25 セレクティスＣｅｌｌｅｃｔｉｓ 癌免疫療法のためのｃｄ３３特異的キメラ抗原受容体
ES2846811T3 (es) * 2014-06-06 2021-07-29 Bluebird Bio Inc Composiciones de células T mejoradas
EP3722316A1 (en) 2014-07-21 2020-10-14 Novartis AG Treatment of cancer using a cd33 chimeric antigen receptor
KR20180042361A (ko) * 2015-08-24 2018-04-25 셀렉티스 통합된 통제가능한 기능들을 가진 키메라 항원 수용체들
WO2017100403A1 (en) * 2015-12-08 2017-06-15 Regents Of The University Of Minnesota Human t cell derived from t cell-derived induced pluripotent stem cell and methods of making and using
SG10201912405TA (en) * 2016-01-11 2020-02-27 Inhibrx Inc Multivalent and multispecific 41bb-binding fusion proteins
WO2017156479A1 (en) * 2016-03-11 2017-09-14 Bluebird Bio, Inc. Ror1 chimeric antigen receptors
US20190241910A1 (en) * 2016-03-11 2019-08-08 Bluebird Bio, Inc. Genome edited immune effector cells
CU24649B1 (es) * 2016-03-19 2023-02-13 Exuma Biotech Corp Retrovirus recombinantes incompetentes de replicación para la transducción de linfocitos y expansión regulada de los mismos
CN109311963A (zh) * 2016-04-14 2019-02-05 蓝鸟生物公司 救助嵌合抗原受体系统
EP3601356A1 (en) * 2017-03-24 2020-02-05 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-cd33 immunotherapy
CN108659131B (zh) * 2018-05-28 2021-09-14 长春力太生物技术有限公司 一种抗ceacam-5的单域抗体及其应用
EP3966245A1 (en) * 2019-05-04 2022-03-16 Inhibrx, Inc. Cd33-binding polypeptides and uses thereof

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JP7765291B2 (ja) 2025-11-06
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SG11202111890RA (en) 2021-11-29
MA55907A (fr) 2022-03-16
KR20220031554A (ko) 2022-03-11
AU2020268379A1 (en) 2022-01-06
JP2022531719A (ja) 2022-07-08
CN114206928A (zh) 2022-03-18
MX2021013591A (es) 2022-02-11
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