CN114206928B - Cd33靶向免疫疗法 - Google Patents

Cd33靶向免疫疗法

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Publication number
CN114206928B
CN114206928B CN202080048661.5A CN202080048661A CN114206928B CN 114206928 B CN114206928 B CN 114206928B CN 202080048661 A CN202080048661 A CN 202080048661A CN 114206928 B CN114206928 B CN 114206928B
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Prior art keywords
gly
polypeptide
cell
domain
leu
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CN202080048661.5A
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Chinese (zh)
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CN114206928A (zh
Inventor
乔丹·贾儒尔
马克·波格森
梁炜亨
凯尔·琼斯
威廉·克拉戈
安吉莉卡·萨纳布里亚
安德鲁·霍兰兹
雅各布·加诺
米尔顿·马
约翰·C·蒂默
布伦丹·P·埃克尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yinxi Bi Biological Science Co
Regeneron Pharmaceuticals Inc
Original Assignee
2 Savinti Biology
Yinxi Bi Biological Science Co
Regeneron Pharmaceuticals Inc
Inhibit Ltd
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Publication of CN114206928A publication Critical patent/CN114206928A/zh
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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CN202080048661.5A 2019-05-08 2020-05-07 Cd33靶向免疫疗法 Active CN114206928B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962845304P 2019-05-08 2019-05-08
US62/845,304 2019-05-08
US201962898392P 2019-09-10 2019-09-10
US62/898,392 2019-09-10
PCT/US2020/031780 WO2020227474A1 (en) 2019-05-08 2020-05-07 Cd33 targeted immunotherapies

Publications (2)

Publication Number Publication Date
CN114206928A CN114206928A (zh) 2022-03-18
CN114206928B true CN114206928B (zh) 2025-08-08

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KR (1) KR20220031554A (enExample)
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WO2020123947A1 (en) 2018-12-14 2020-06-18 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
CN116867806A (zh) * 2021-02-10 2023-10-10 先声再明医药有限公司 人cd33抗体及其用途
WO2023108158A2 (en) * 2021-12-10 2023-06-15 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Methods and compositions for modulating the activity of a dimerizing agent regulated immunomodulatory complex
AU2023248532A1 (en) * 2022-04-08 2024-11-21 Regeneron Pharmaceuticals, Inc. Multipartite receptor and signaling complexes
KR20250007535A (ko) * 2022-04-22 2025-01-14 인히브릭스 바이오사이언스, 인크. Siglec-8 결합 단백질 및 그 용도
WO2023230512A1 (en) 2022-05-26 2023-11-30 2Seventy Bio, Inc. Compositions for maintaining lentiviral vector and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014576A1 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using a cd33 chimeric antigen receptor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100003253A1 (en) 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
EP3027204B1 (en) 2013-07-29 2022-01-05 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
WO2015142661A1 (en) * 2014-03-15 2015-09-24 Novartis Ag Regulatable chimeric antigen receptor
ES2765710T3 (es) * 2014-04-03 2020-06-10 Cellectis Receptores de antígeno quimérico específicos de CD33 para la inmunoterapia del cáncer
RS61406B1 (sr) * 2014-06-06 2021-03-31 Bluebird Bio Inc Poboljšane kompozicije t ćelija
JP6894430B2 (ja) * 2015-08-24 2021-06-30 セレクティスＣｅｌｌｅｃｔｉｓ 統合された制御機能を有するキメラ抗原受容体
CA3048996A1 (en) 2015-12-08 2017-06-15 Regents Of The University Of Minnesota Human t cell derived from t cell-derived induced pluripotent stem cell and methods of making and using
IL304871A (en) 2016-01-11 2023-10-01 Inhibrx Inc Multispecific and multivalent binding fusion proteins - 41BB, preparations containing them and their uses
US20190241910A1 (en) * 2016-03-11 2019-08-08 Bluebird Bio, Inc. Genome edited immune effector cells
WO2017156479A1 (en) 2016-03-11 2017-09-14 Bluebird Bio, Inc. Ror1 chimeric antigen receptors
CN108884460B (zh) 2016-03-19 2023-04-28 埃克苏马生物技术公司 淋巴细胞转导及其扩增调节的方法与组合物
CA3020993A1 (en) 2016-04-14 2017-10-19 Bluebird Bio, Inc. Salvage chimeric antigen receptor systems
AU2018240556B2 (en) 2017-03-24 2025-02-27 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-CD33 immunotherapy
CN108659131B (zh) * 2018-05-28 2021-09-14 长春力太生物技术有限公司 一种抗ceacam-5的单域抗体及其应用
EP3966245A1 (en) * 2019-05-04 2022-03-16 Inhibrx, Inc. Cd33-binding polypeptides and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014576A1 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using a cd33 chimeric antigen receptor

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