JP7763780B2 - 抗cd73/抗pd-1二重特異性抗体及びその使用 - Google Patents

抗cd73/抗pd-1二重特異性抗体及びその使用

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Publication number
JP7763780B2
JP7763780B2 JP2022564073A JP2022564073A JP7763780B2 JP 7763780 B2 JP7763780 B2 JP 7763780B2 JP 2022564073 A JP2022564073 A JP 2022564073A JP 2022564073 A JP2022564073 A JP 2022564073A JP 7763780 B2 JP7763780 B2 JP 7763780B2
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seq
amino acid
variable region
chain variable
set forth
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JP2023522730A (ja
JP2023522730A5 (https=
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ジャン,ペン
リ,バイヨン
シア,ユ
ワン,ジョンミン
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Akeso Pharmaceuticals Inc
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Akeso Biopharma Inc
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022002028A2 (pt) * 2019-08-02 2022-04-12 Cttq Akeso Shanghai Biomed Tech Co Ltd Anticorpo anti-pd-1 e uso farmacêutico do mesmo
CN120590533A (zh) * 2020-10-23 2025-09-05 中山康方生物医药有限公司 抗cd73的抗体及其用途
CN115073588B (zh) * 2021-03-12 2024-06-18 中山康方生物医药有限公司 提高含有免疫球蛋白Fc片段的药物的安全性的方法
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド Trop-2発現がんを治療するための併用療法
KR20250026284A (ko) * 2022-06-22 2025-02-25 아케소 바이오파마, 인크. 약학 조성물 및 이의 용도
CN116813786B (zh) * 2023-08-03 2024-11-26 贝达药业股份有限公司 抗cd73抗体及其应用
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019510734A (ja) 2015-12-30 2019-04-18 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. 抗体および抗体複合体
JP2019514844A (ja) 2016-03-04 2019-06-06 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 抗cd73抗体を用いた併用療法
JP2019533475A (ja) 2016-08-23 2019-11-21 康方▲藥▼▲業▼有限公司Akeso Pharmaceuticals, Inc. 抗ctla4−抗pd−1二機能性抗体、その医薬組成物および使用
JP2019534034A (ja) 2016-08-23 2019-11-28 中山康方生物医▲藥▼有限公司Akeso Biopharma,Inc. 抗pd1モノクローナル抗体、その医薬組成物およびその使用
WO2020020307A1 (en) 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
WO2020043184A1 (zh) 2018-08-30 2020-03-05 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
JP2023522365A (ja) 2020-04-22 2023-05-30 アケソ・バイオファーマ・インコーポレイテッド 抗cd73抗体とその利用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
WO2011159877A2 (en) * 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
GB2537445A (en) * 2014-11-10 2016-10-19 Medimmune Ltd Binding molecules specific for CD73 and uses thereof
GB2538120A (en) 2014-11-11 2016-11-09 Medimmune Ltd Therapeutic combinations comprising anti-CD73 antibodies and uses thereof
AU2015349878A1 (en) * 2014-11-21 2017-05-25 Bristol-Myers Squibb Company Antibodies against CD73 and uses thereof
US20190330335A1 (en) * 2015-10-06 2019-10-31 Alector Llc Anti-trem2 antibodies and methods of use thereof
EP3494991A4 (en) * 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES
KR20200096921A (ko) * 2017-11-06 2020-08-14 코버스 파마슈티칼스, 인크. 암 치료를 위한 아데노신 경로 억제제
EP3762030A4 (en) * 2018-03-09 2022-01-05 Phanes Therapeutics, Inc. ANTI-CD73 ANTIBODIES AND USES THEREOF
BR112020020826A2 (pt) * 2018-04-12 2021-01-19 Bristol-Myers Squibb Company Terapia de combinação anticâncer com anticorpo antagonista de cd73 e anticorpo antagonista do eixo pd-1/pd-l1

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019510734A (ja) 2015-12-30 2019-04-18 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. 抗体および抗体複合体
JP2019514844A (ja) 2016-03-04 2019-06-06 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 抗cd73抗体を用いた併用療法
JP2019533475A (ja) 2016-08-23 2019-11-21 康方▲藥▼▲業▼有限公司Akeso Pharmaceuticals, Inc. 抗ctla4−抗pd−1二機能性抗体、その医薬組成物および使用
JP2019534034A (ja) 2016-08-23 2019-11-28 中山康方生物医▲藥▼有限公司Akeso Biopharma,Inc. 抗pd1モノクローナル抗体、その医薬組成物およびその使用
WO2020020307A1 (en) 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
WO2020043184A1 (zh) 2018-08-30 2020-03-05 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
JP2023522365A (ja) 2020-04-22 2023-05-30 アケソ・バイオファーマ・インコーポレイテッド 抗cd73抗体とその利用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Oncotarget,2017年,Vol. 8, No. 17,pp. 29067-29079
STN REGISTRY, RN 2550560-20-6 [online], 2020.12.08[検索日2023.10.17]

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