KR20230004726A - 항-cd73/항-pd-1 이중특이항체 및 이의 용도 - Google Patents

항-cd73/항-pd-1 이중특이항체 및 이의 용도 Download PDF

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KR20230004726A
KR20230004726A KR1020227040580A KR20227040580A KR20230004726A KR 20230004726 A KR20230004726 A KR 20230004726A KR 1020227040580 A KR1020227040580 A KR 1020227040580A KR 20227040580 A KR20227040580 A KR 20227040580A KR 20230004726 A KR20230004726 A KR 20230004726A
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seq
amino acid
antibody
acid sequence
variable region
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펑 장
빠이용 리
유 샤
쭝민 왕
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아케소 바이오파마, 인크.
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
AU2020324185A1 (en) * 2019-08-02 2022-03-03 CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. Anti-PD-1 antibody and medical use thereof
US20240018254A1 (en) * 2020-10-23 2024-01-18 Akeso Biopharma, Inc Anti-cd73 antibody and use thereof
CN118530341A (zh) * 2021-03-12 2024-08-23 中山康方生物医药有限公司 提高含有免疫球蛋白Fc片段的药物的有效性的方法
CN119173276A (zh) 2022-04-13 2024-12-20 吉利德科学公司 用于治疗表达Trop-2的癌症的组合疗法
JP2025520232A (ja) * 2022-06-22 2025-07-03 中山康方生物医▲藥▼有限公司 医薬組成物及びその使用
CN116813786B (zh) * 2023-08-03 2024-11-26 贝达药业股份有限公司 抗cd73抗体及其应用
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JP2013532153A (ja) * 2010-06-18 2013-08-15 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体
DK3218406T4 (da) * 2014-11-10 2024-12-09 Medimmune Ltd Bindingsmolekyler, der er specifikke for cd73, og anvendelser deraf
EP3218407A1 (en) 2014-11-11 2017-09-20 Medimmune Limited Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof
MY189836A (en) * 2014-11-21 2022-03-11 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
AU2016334051B2 (en) * 2015-10-06 2023-10-26 Alector Llc Anti-TREM2 antibodies and methods of use thereof
KR102799807B1 (ko) * 2015-12-30 2025-04-24 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
KR20230038311A (ko) * 2016-03-04 2023-03-17 브리스톨-마이어스 스큅 컴퍼니 항-cd73 항체와의 조합 요법
TWI693940B (zh) * 2016-08-05 2020-05-21 日商中外製藥股份有限公司 Il-8相關疾病之治療用或預防用組成物
CN106977602B (zh) * 2016-08-23 2018-09-25 中山康方生物医药有限公司 一种抗pd1单克隆抗体、其药物组合物及其用途
CN106967172B (zh) * 2016-08-23 2019-01-08 康方药业有限公司 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
CN111565722A (zh) * 2017-11-06 2020-08-21 科尔沃斯制药股份有限公司 用于癌症治疗的腺苷路径抑制剂
KR102804816B1 (ko) * 2018-03-09 2025-05-09 페인스 테라퓨틱스 인코포레이티드 항-cd73 항체 및 이의 용도
US20210147570A1 (en) * 2018-04-12 2021-05-20 Bristol-Myers Squibb Company Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody
WO2020020307A1 (en) * 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
BR112022021397A2 (pt) * 2020-04-22 2023-02-07 Akeso Biopharma Inc Anticorpo anti-cd73, polipeptídeo isolado, molécula de ácido nucleico, vetor, célula hospedeira, conjugado, proteína de fusão ou anticorpo multiespecífico, kit, composição farmacêutica, uso do anticorpo e linhagem celular de hibridoma

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