JP7748386B2 - がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与 - Google Patents

がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与

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Publication number
JP7748386B2
JP7748386B2 JP2022560245A JP2022560245A JP7748386B2 JP 7748386 B2 JP7748386 B2 JP 7748386B2 JP 2022560245 A JP2022560245 A JP 2022560245A JP 2022560245 A JP2022560245 A JP 2022560245A JP 7748386 B2 JP7748386 B2 JP 7748386B2
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Japan
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
per day
salt form
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JP2022560245A
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English (en)
Japanese (ja)
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JP2023521036A5 (https=
JP2023521036A (ja
Inventor
ルソン ルオ，
ジユ タン，
バドレディン エドゥリス，
トッド ウェブスター シアラー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SpringWorks Therapeutics Inc
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SpringWorks Therapeutics Inc
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Publication of JP2023521036A publication Critical patent/JP2023521036A/ja
Publication of JP2023521036A5 publication Critical patent/JP2023521036A5/ja
Priority to JP2025102055A priority Critical patent/JP2025120501A/ja
Application granted granted Critical
Publication of JP7748386B2 publication Critical patent/JP7748386B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022560245A 2020-04-03 2021-04-02 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与 Active JP7748386B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025102055A JP2025120501A (ja) 2020-04-03 2025-06-18 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063005153P 2020-04-03 2020-04-03
US63/005,153 2020-04-03
PCT/US2021/025551 WO2021202981A1 (en) 2020-04-03 2021-04-02 Co-administration of mirdametinib and lifirafenib for use in treating cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025102055A Division JP2025120501A (ja) 2020-04-03 2025-06-18 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与

Publications (3)

Publication Number Publication Date
JP2023521036A JP2023521036A (ja) 2023-05-23
JP2023521036A5 JP2023521036A5 (https=) 2024-04-11
JP7748386B2 true JP7748386B2 (ja) 2025-10-02

Family

ID=75674969

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022560245A Active JP7748386B2 (ja) 2020-04-03 2021-04-02 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与
JP2025102055A Pending JP2025120501A (ja) 2020-04-03 2025-06-18 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025102055A Pending JP2025120501A (ja) 2020-04-03 2025-06-18 がんの治療で使用するためのミルダメチニブ及びリフィラフェニブの同時投与

Country Status (21)

Country Link
US (1) US20230128315A1 (https=)
EP (1) EP4125842B1 (https=)
JP (2) JP7748386B2 (https=)
KR (1) KR20230048476A (https=)
CN (1) CN116194095B (https=)
AU (1) AU2021246141A1 (https=)
BR (1) BR112022019914A2 (https=)
CA (1) CA3174223A1 (https=)
CL (1) CL2022002682A1 (https=)
CO (1) CO2022015891A2 (https=)
DK (1) DK4125842T3 (https=)
ES (1) ES2985012T3 (https=)
FI (1) FI4125842T3 (https=)
HU (1) HUE067894T2 (https=)
IL (1) IL296878A (https=)
MX (1) MX2022012351A (https=)
PE (1) PE20231211A1 (https=)
PL (1) PL4125842T3 (https=)
PT (1) PT4125842T (https=)
TW (1) TWI893097B (https=)
WO (1) WO2021202981A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3254428A1 (en) * 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. TREATMENT OF PLEXIFORM NEUROFIBROMAS (NP) ASSOCIATED WITH TYPE 1 NEUROFIBROMATOSIS (NF1) IN PEDIATRIC PATIENTS WITH MIRDAMETINIB
WO2023178276A1 (en) * 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. Treatment of pancreatic ductal adenocarcinoma with mirdametinib
WO2023209611A1 (en) * 2022-04-26 2023-11-02 Beigene Switzerland Gmbh Methods of treating cancer with a b-raf inhibitor, in particular lifirafenib
JP2025534589A (ja) * 2022-10-14 2025-10-17 スプリングワークス、セラピューティクス、インコーポレイテッド がんの治療に使用するための併用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018511634A (ja) 2015-04-15 2018-04-26 ベイジーン リミテッド Ｂ−ｒａｆキナーゼのマレイン酸塩、結晶形、調整方法、及びその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2013148817A (ru) * 2011-04-01 2015-05-10 Дженентек, Инк. Комбинации соединений-ингибиторов акт и мек и способы их применения
WO2019113345A1 (en) * 2017-12-06 2019-06-13 Spyro Mousses Combination of cancer therapeutics for treatment of cancer and hyperproliferative diseases
EP3560516A1 (en) * 2018-04-27 2019-10-30 Bergen Teknologioverforing AS Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018511634A (ja) 2015-04-15 2018-04-26 ベイジーン リミテッド Ｂ−ｒａｆキナーゼのマレイン酸塩、結晶形、調整方法、及びその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SpringWorks Therapeutics Announces Initiation ofPhase 1b Clinical Trial of MEK Inhibitor PD-0325901in Combination with BeiGene’s RAF Dimer InhibitorLifirafenib in Advanced or Refractory Solid Tumors[online]，2019年，<URL:https://ir.springworkstx.com/news-releases/news-release-details/springworks-therapeutics-announces-initiation-phase-1b-clinical/>検索日２０２５年３月２１日
Study of the Safety and Pharmacokinetics of BGB-283(Lifirafenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors[online]，2019年，<URL:https://clinicaltrials.gov/study/NCT03905148>検索日２０２５年３月２１日

Also Published As

Publication number Publication date
JP2025120501A (ja) 2025-08-15
CN116194095A (zh) 2023-05-30
AU2021246141A1 (en) 2022-12-01
EP4125842A1 (en) 2023-02-08
KR20230048476A (ko) 2023-04-11
ES2985012T3 (es) 2024-11-04
BR112022019914A2 (pt) 2022-12-13
TW202207910A (zh) 2022-03-01
WO2021202981A1 (en) 2021-10-07
CN116194095B (zh) 2024-09-13
IL296878A (en) 2022-12-01
HUE067894T2 (hu) 2024-11-28
CO2022015891A2 (es) 2023-05-08
JP2023521036A (ja) 2023-05-23
DK4125842T3 (da) 2024-07-22
EP4125842B1 (en) 2024-06-05
PE20231211A1 (es) 2023-08-17
TWI893097B (zh) 2025-08-11
CA3174223A1 (en) 2021-10-07
PL4125842T3 (pl) 2024-10-14
MX2022012351A (es) 2023-03-13
CL2022002682A1 (es) 2023-06-16
US20230128315A1 (en) 2023-04-27
FI4125842T3 (fi) 2024-08-06
PT4125842T (pt) 2024-08-06

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