KR20230048476A - 암 치료 시에 사용하기 위한 미르다메티닙과 리피라페닙의 공동 투여 - Google Patents

암 치료 시에 사용하기 위한 미르다메티닙과 리피라페닙의 공동 투여 Download PDF

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KR20230048476A
KR20230048476A KR1020227038490A KR20227038490A KR20230048476A KR 20230048476 A KR20230048476 A KR 20230048476A KR 1020227038490 A KR1020227038490 A KR 1020227038490A KR 20227038490 A KR20227038490 A KR 20227038490A KR 20230048476 A KR20230048476 A KR 20230048476A
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South Korea
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compound
pharmaceutically acceptable
acceptable salt
administered
per day
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English (en)
Korean (ko)
Inventor
루송 루오
지위 탕
바드레딘 에드리스
토드 웹스터 시어러
Original Assignee
베이진 리미티드
스프링웍스 테라퓨틱스, 인크.
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Publication of KR20230048476A publication Critical patent/KR20230048476A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020227038490A 2020-04-03 2021-04-02 암 치료 시에 사용하기 위한 미르다메티닙과 리피라페닙의 공동 투여 Pending KR20230048476A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063005153P 2020-04-03 2020-04-03
US63/005,153 2020-04-03
PCT/US2021/025551 WO2021202981A1 (en) 2020-04-03 2021-04-02 Co-administration of mirdametinib and lifirafenib for use in treating cancers

Publications (1)

Publication Number Publication Date
KR20230048476A true KR20230048476A (ko) 2023-04-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227038490A Pending KR20230048476A (ko) 2020-04-03 2021-04-02 암 치료 시에 사용하기 위한 미르다메티닙과 리피라페닙의 공동 투여

Country Status (21)

Country Link
US (1) US20230128315A1 (https=)
EP (1) EP4125842B1 (https=)
JP (2) JP7748386B2 (https=)
KR (1) KR20230048476A (https=)
CN (1) CN116194095B (https=)
AU (1) AU2021246141A1 (https=)
BR (1) BR112022019914A2 (https=)
CA (1) CA3174223A1 (https=)
CL (1) CL2022002682A1 (https=)
CO (1) CO2022015891A2 (https=)
DK (1) DK4125842T3 (https=)
ES (1) ES2985012T3 (https=)
FI (1) FI4125842T3 (https=)
HU (1) HUE067894T2 (https=)
IL (1) IL296878A (https=)
MX (1) MX2022012351A (https=)
PE (1) PE20231211A1 (https=)
PL (1) PL4125842T3 (https=)
PT (1) PT4125842T (https=)
TW (1) TWI893097B (https=)
WO (1) WO2021202981A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3254428A1 (en) * 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. TREATMENT OF PLEXIFORM NEUROFIBROMAS (NP) ASSOCIATED WITH TYPE 1 NEUROFIBROMATOSIS (NF1) IN PEDIATRIC PATIENTS WITH MIRDAMETINIB
WO2023178276A1 (en) * 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. Treatment of pancreatic ductal adenocarcinoma with mirdametinib
WO2023209611A1 (en) * 2022-04-26 2023-11-02 Beigene Switzerland Gmbh Methods of treating cancer with a b-raf inhibitor, in particular lifirafenib
JP2025534589A (ja) * 2022-10-14 2025-10-17 スプリングワークス、セラピューティクス、インコーポレイテッド がんの治療に使用するための併用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2013148817A (ru) * 2011-04-01 2015-05-10 Дженентек, Инк. Комбинации соединений-ингибиторов акт и мек и способы их применения
CN113307805A (zh) * 2015-04-15 2021-08-27 百济神州有限公司 B-raf激酶抑制剂的马来酸盐、其结晶形式、制备方法和用途
WO2019113345A1 (en) * 2017-12-06 2019-06-13 Spyro Mousses Combination of cancer therapeutics for treatment of cancer and hyperproliferative diseases
EP3560516A1 (en) * 2018-04-27 2019-10-30 Bergen Teknologioverforing AS Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof

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Publication number Publication date
JP2025120501A (ja) 2025-08-15
CN116194095A (zh) 2023-05-30
AU2021246141A1 (en) 2022-12-01
EP4125842A1 (en) 2023-02-08
ES2985012T3 (es) 2024-11-04
BR112022019914A2 (pt) 2022-12-13
TW202207910A (zh) 2022-03-01
WO2021202981A1 (en) 2021-10-07
CN116194095B (zh) 2024-09-13
IL296878A (en) 2022-12-01
HUE067894T2 (hu) 2024-11-28
CO2022015891A2 (es) 2023-05-08
JP2023521036A (ja) 2023-05-23
JP7748386B2 (ja) 2025-10-02
DK4125842T3 (da) 2024-07-22
EP4125842B1 (en) 2024-06-05
PE20231211A1 (es) 2023-08-17
TWI893097B (zh) 2025-08-11
CA3174223A1 (en) 2021-10-07
PL4125842T3 (pl) 2024-10-14
MX2022012351A (es) 2023-03-13
CL2022002682A1 (es) 2023-06-16
US20230128315A1 (en) 2023-04-27
FI4125842T3 (fi) 2024-08-06
PT4125842T (pt) 2024-08-06

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