JP7729536B2 - 白血球捕捉デバイス - Google Patents

白血球捕捉デバイス

Info

Publication number
JP7729536B2
JP7729536B2 JP2024511499A JP2024511499A JP7729536B2 JP 7729536 B2 JP7729536 B2 JP 7729536B2 JP 2024511499 A JP2024511499 A JP 2024511499A JP 2024511499 A JP2024511499 A JP 2024511499A JP 7729536 B2 JP7729536 B2 JP 7729536B2
Authority
JP
Japan
Prior art keywords
buffer
layer
leukocyte
capture
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2024511499A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2023189095A1 (https=
JPWO2023189095A5 (https=
Inventor
麻子 中村
健太 高橋
悠雅 千原
隆幸 小森
直広 藤澤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nok Corp
Ibaraki University NUC
Original Assignee
Nok Corp
Ibaraki University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nok Corp, Ibaraki University NUC filed Critical Nok Corp
Publication of JPWO2023189095A1 publication Critical patent/JPWO2023189095A1/ja
Publication of JPWO2023189095A5 publication Critical patent/JPWO2023189095A5/ja
Application granted granted Critical
Publication of JP7729536B2 publication Critical patent/JP7729536B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2024511499A 2022-03-28 2023-02-27 白血球捕捉デバイス Active JP7729536B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022051142 2022-03-28
JP2022051142 2022-03-28
PCT/JP2023/007099 WO2023189095A1 (ja) 2022-03-28 2023-02-27 白血球捕捉デバイス

Publications (3)

Publication Number Publication Date
JPWO2023189095A1 JPWO2023189095A1 (https=) 2023-10-05
JPWO2023189095A5 JPWO2023189095A5 (https=) 2024-12-24
JP7729536B2 true JP7729536B2 (ja) 2025-08-26

Family

ID=88200597

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024511499A Active JP7729536B2 (ja) 2022-03-28 2023-02-27 白血球捕捉デバイス

Country Status (5)

Country Link
US (1) US20250214080A1 (https=)
EP (1) EP4502568A4 (https=)
JP (1) JP7729536B2 (https=)
CN (1) CN118922704A (https=)
WO (1) WO2023189095A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116324367A (zh) * 2020-09-29 2023-06-23 Nok株式会社 微颗粒捕获装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003102710A (ja) 2001-09-30 2003-04-08 Hiroshi Otsuka 血液の分析方法ならびに分析装置
JP2005140790A (ja) 2003-11-07 2005-06-02 Steag Microparts Gmbh 粒子を含む液体から液状成分を分離するための微細構造型分離装置および分離方法
JP2008538282A (ja) 2005-04-05 2008-10-23 セルポイント ダイアグノスティクス， インコーポレイテッド 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法
US20090194420A1 (en) 2008-02-01 2009-08-06 Lawrence Livermore National Security, Llc. Systems and Methods for Separating Particles and/or Substances from a Sample Fluid
JP2012088055A (ja) 2010-09-21 2012-05-10 Tokyo Univ Of Agriculture & Technology 微量血液からの白血球ポピュレーション解析法
JP2017000921A (ja) 2015-06-05 2017-01-05 国立大学法人 東京大学 曲げ弾性係数が小さい粒子の分離捕捉装置
WO2022070841A1 (ja) 2020-09-29 2022-04-07 Nok株式会社 白血球捕捉デバイス

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5231782B2 (ja) 2007-10-26 2013-07-10 学校法人常翔学園 固液分離機能を有する装置及びその製造方法
CN102360010B (zh) * 2011-08-05 2014-01-01 上海交通大学 一种全血癌细胞捕获集成微流控芯片
US10996216B2 (en) 2015-02-27 2021-05-04 Toppan Printing Co., Ltd. Method for separating cells, and device therefor
CN107723207B (zh) * 2017-11-01 2019-01-01 深圳市瑞格生物科技有限公司 一种分离捕获细胞的芯片及其在肿瘤细胞分选中的应用
JP7517921B2 (ja) 2020-09-18 2024-07-17 株式会社エンプラス ギヤ

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003102710A (ja) 2001-09-30 2003-04-08 Hiroshi Otsuka 血液の分析方法ならびに分析装置
JP2005140790A (ja) 2003-11-07 2005-06-02 Steag Microparts Gmbh 粒子を含む液体から液状成分を分離するための微細構造型分離装置および分離方法
JP2008538282A (ja) 2005-04-05 2008-10-23 セルポイント ダイアグノスティクス， インコーポレイテッド 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法
US20090194420A1 (en) 2008-02-01 2009-08-06 Lawrence Livermore National Security, Llc. Systems and Methods for Separating Particles and/or Substances from a Sample Fluid
JP2012088055A (ja) 2010-09-21 2012-05-10 Tokyo Univ Of Agriculture & Technology 微量血液からの白血球ポピュレーション解析法
JP2017000921A (ja) 2015-06-05 2017-01-05 国立大学法人 東京大学 曲げ弾性係数が小さい粒子の分離捕捉装置
WO2022070841A1 (ja) 2020-09-29 2022-04-07 Nok株式会社 白血球捕捉デバイス

Also Published As

Publication number Publication date
JPWO2023189095A1 (https=) 2023-10-05
EP4502568A1 (en) 2025-02-05
WO2023189095A1 (ja) 2023-10-05
CN118922704A (zh) 2024-11-08
EP4502568A4 (en) 2026-04-08
US20250214080A1 (en) 2025-07-03

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