CN118922704A - 白血球捕捉设备 - Google Patents

白血球捕捉设备 Download PDF

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Publication number
CN118922704A
CN118922704A CN202380029496.2A CN202380029496A CN118922704A CN 118922704 A CN118922704 A CN 118922704A CN 202380029496 A CN202380029496 A CN 202380029496A CN 118922704 A CN118922704 A CN 118922704A
Authority
CN
China
Prior art keywords
white blood
layer
buffer
blood cell
blood cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380029496.2A
Other languages
English (en)
Chinese (zh)
Inventor
中村麻子
高桥健太
千原悠雅
小森隆幸
藤泽直广
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Di'nao Co ltd
Nok Corp
Ibaraki University NUC
Original Assignee
Di'nao Co ltd
Nok Corp
Ibaraki University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Di'nao Co ltd, Nok Corp, Ibaraki University NUC filed Critical Di'nao Co ltd
Publication of CN118922704A publication Critical patent/CN118922704A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202380029496.2A 2022-03-28 2023-02-27 白血球捕捉设备 Pending CN118922704A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-051142 2022-03-28
JP2022051142 2022-03-28
PCT/JP2023/007099 WO2023189095A1 (ja) 2022-03-28 2023-02-27 白血球捕捉デバイス

Publications (1)

Publication Number Publication Date
CN118922704A true CN118922704A (zh) 2024-11-08

Family

ID=88200597

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380029496.2A Pending CN118922704A (zh) 2022-03-28 2023-02-27 白血球捕捉设备

Country Status (5)

Country Link
US (1) US20250214080A1 (https=)
EP (1) EP4502568A4 (https=)
JP (1) JP7729536B2 (https=)
CN (1) CN118922704A (https=)
WO (1) WO2023189095A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116324367A (zh) * 2020-09-29 2023-06-23 Nok株式会社 微颗粒捕获装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003102710A (ja) * 2001-09-30 2003-04-08 Hiroshi Otsuka 血液の分析方法ならびに分析装置
DE10352535A1 (de) * 2003-11-07 2005-06-16 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
EP1874920A4 (en) * 2005-04-05 2009-11-04 Cellpoint Diagnostics DEVICES AND METHOD FOR ENRICHING AND CHANGING CIRCULATING TUMOR CELLS AND OTHER PARTICLES
JP5231782B2 (ja) 2007-10-26 2013-07-10 学校法人常翔学園 固液分離機能を有する装置及びその製造方法
US9480935B2 (en) * 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
JP5626727B2 (ja) * 2010-09-21 2014-11-19 国立大学法人東京農工大学 微量血液からの白血球ポピュレーション解析法
CN102360010B (zh) * 2011-08-05 2014-01-01 上海交通大学 一种全血癌细胞捕获集成微流控芯片
US10996216B2 (en) 2015-02-27 2021-05-04 Toppan Printing Co., Ltd. Method for separating cells, and device therefor
JP6615499B2 (ja) * 2015-06-05 2019-12-04 国立大学法人 東京大学 細胞またはリポソーム粒子の分離捕捉装置
CN107723207B (zh) * 2017-11-01 2019-01-01 深圳市瑞格生物科技有限公司 一种分离捕获细胞的芯片及其在肿瘤细胞分选中的应用
JP7517921B2 (ja) 2020-09-18 2024-07-17 株式会社エンプラス ギヤ
WO2022070841A1 (ja) * 2020-09-29 2022-04-07 Nok株式会社 白血球捕捉デバイス

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116324367A (zh) * 2020-09-29 2023-06-23 Nok株式会社 微颗粒捕获装置

Also Published As

Publication number Publication date
JPWO2023189095A1 (https=) 2023-10-05
EP4502568A1 (en) 2025-02-05
WO2023189095A1 (ja) 2023-10-05
JP7729536B2 (ja) 2025-08-26
EP4502568A4 (en) 2026-04-08
US20250214080A1 (en) 2025-07-03

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