JP7715715B2 - 新規複素環式化合物 - Google Patents

新規複素環式化合物

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Publication number
JP7715715B2
JP7715715B2 JP2022544123A JP2022544123A JP7715715B2 JP 7715715 B2 JP7715715 B2 JP 7715715B2 JP 2022544123 A JP2022544123 A JP 2022544123A JP 2022544123 A JP2022544123 A JP 2022544123A JP 7715715 B2 JP7715715 B2 JP 7715715B2
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JP
Japan
Prior art keywords
phenyl
carbonyl
methyl
chloro
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022544123A
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English (en)
Japanese (ja)
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JP2023510971A5 (https=
JP2023510971A (ja
Inventor
チェン，ジャンリーン
ハン，シーンチュン
クラマー，クリスティアン
ラーナー，クリスティアン
リウ，ヨーンチアーン
ネッテコベン，マティアス
プフリーガー，フィリップ
ピュールマン，ベルント
ワーン，ジエンホワ
ワーン，リーシャ
ワーン，ミン
ワーン，ヨーングワーン
ヤーン，ソーン
ジョウ，チェンガーン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2023510971A publication Critical patent/JP2023510971A/ja
Publication of JP2023510971A5 publication Critical patent/JP2023510971A5/ja
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022544123A 2020-01-22 2021-01-20 新規複素環式化合物 Active JP7715715B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020073830 2020-01-22
CNPCT/CN2020/073830 2020-01-22
PCT/EP2021/051095 WO2021148420A1 (en) 2020-01-22 2021-01-20 Novel heterocyclic compounds

Publications (3)

Publication Number Publication Date
JP2023510971A JP2023510971A (ja) 2023-03-15
JP2023510971A5 JP2023510971A5 (https=) 2024-01-22
JP7715715B2 true JP7715715B2 (ja) 2025-07-30

Family

ID=74418400

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022544123A Active JP7715715B2 (ja) 2020-01-22 2021-01-20 新規複素環式化合物

Country Status (5)

Country Link
US (1) US20220396565A1 (https=)
EP (1) EP4093734A1 (https=)
JP (1) JP7715715B2 (https=)
CN (1) CN114981259B (https=)
WO (1) WO2021148420A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024506021A (ja) * 2021-02-07 2024-02-08 エフ． ホフマン－ラ ロシュ アーゲー 新規ヘテロアリール置換イミダゾール誘導体
JP2024525793A (ja) * 2021-07-15 2024-07-12 エフ． ホフマン－ラ ロシュ アーゲー イミダゾール誘導体及びその抗生物質としての使用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4211116B1 (en) * 2020-09-07 2024-08-07 F. Hoffmann-La Roche AG Novel heterocyclic antibiotics
CN117715892A (zh) * 2021-07-06 2024-03-15 豪夫迈·罗氏有限公司 用于治疗细菌感染的季铵阳离子取代化合物
JP2025508473A (ja) * 2022-02-25 2025-03-26 エフ． ホフマン－ラ ロシュ アーゲー 両性イオン性抗菌化合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004519421A (ja) 2000-08-01 2004-07-02 アイシス・ファーマシューティカルス・インコーポレーテッド 抗微生物性ビアリール化合物
JP2017518360A (ja) 2014-04-17 2017-07-06 ザ ユニバーシティ オブ ノッティンガム 化合物
WO2019006126A1 (en) 2017-06-29 2019-01-03 Rigel Pharmaceuticals, Inc. KINASE INHIBITORS AND METHODS OF MAKING AND USING THEM
WO2019016782A1 (en) 2017-07-21 2019-01-24 The University Of Hong Kong COMPOUNDS AFFECTING THE PRODUCTION OF PIGMENTS AND THEIR USE FOR THE TREATMENT OF BACTERIAL DISEASES
JP2022513851A (ja) 2018-12-17 2022-02-09 エフ．ホフマン－ラ ロシュ アーゲー 抗菌剤としてのイミダゾピラジン誘導体
JP2022525029A (ja) 2019-03-08 2022-05-11 エフ．ホフマン－ラ ロシュ アーゲー 新規イミダゾール－ピラゾール誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004519421A (ja) 2000-08-01 2004-07-02 アイシス・ファーマシューティカルス・インコーポレーテッド 抗微生物性ビアリール化合物
JP2017518360A (ja) 2014-04-17 2017-07-06 ザ ユニバーシティ オブ ノッティンガム 化合物
WO2019006126A1 (en) 2017-06-29 2019-01-03 Rigel Pharmaceuticals, Inc. KINASE INHIBITORS AND METHODS OF MAKING AND USING THEM
WO2019016782A1 (en) 2017-07-21 2019-01-24 The University Of Hong Kong COMPOUNDS AFFECTING THE PRODUCTION OF PIGMENTS AND THEIR USE FOR THE TREATMENT OF BACTERIAL DISEASES
JP2022513851A (ja) 2018-12-17 2022-02-09 エフ．ホフマン－ラ ロシュ アーゲー 抗菌剤としてのイミダゾピラジン誘導体
JP2022525029A (ja) 2019-03-08 2022-05-11 エフ．ホフマン－ラ ロシュ アーゲー 新規イミダゾール－ピラゾール誘導体

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters，2010年，20(24)，7308-7311
Chemical and Pharmaceutical Bulletin，2016年，64(11)，1622-1629
Journal of Medicinal Chemistry，2002年，45(21)，4669-4678
Mini-Reviews in Medicinal Chemistry，2013年，13(12)，1812-1835

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024506021A (ja) * 2021-02-07 2024-02-08 エフ． ホフマン－ラ ロシュ アーゲー 新規ヘテロアリール置換イミダゾール誘導体
JP2024525793A (ja) * 2021-07-15 2024-07-12 エフ． ホフマン－ラ ロシュ アーゲー イミダゾール誘導体及びその抗生物質としての使用

Also Published As

Publication number Publication date
CN114981259B (zh) 2024-06-18
WO2021148420A1 (en) 2021-07-29
EP4093734A1 (en) 2022-11-30
US20220396565A1 (en) 2022-12-15
JP2023510971A (ja) 2023-03-15
CN114981259A (zh) 2022-08-30

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