CN114981259B - 新型杂环化合物 - Google Patents

新型杂环化合物 Download PDF

Info

Publication number
CN114981259B
CN114981259B CN202180010360.8A CN202180010360A CN114981259B CN 114981259 B CN114981259 B CN 114981259B CN 202180010360 A CN202180010360 A CN 202180010360A CN 114981259 B CN114981259 B CN 114981259B
Authority
CN
China
Prior art keywords
phenyl
carbonyl
methyl
chloro
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180010360.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN114981259A (zh
Inventor
程战领
韩兴春
C·克莱默
C·莱纳
刘永强
M·内特科文
P·菲列格尔
B·普埃尔曼
王建华
王利莎
汪敏
王永光
杨松
周辰刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN114981259A publication Critical patent/CN114981259A/zh
Application granted granted Critical
Publication of CN114981259B publication Critical patent/CN114981259B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202180010360.8A 2020-01-22 2021-01-20 新型杂环化合物 Active CN114981259B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020073830 2020-01-22
CNPCT/CN2020/073830 2020-01-22
PCT/EP2021/051095 WO2021148420A1 (en) 2020-01-22 2021-01-20 Novel heterocyclic compounds

Publications (2)

Publication Number Publication Date
CN114981259A CN114981259A (zh) 2022-08-30
CN114981259B true CN114981259B (zh) 2024-06-18

Family

ID=74418400

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180010360.8A Active CN114981259B (zh) 2020-01-22 2021-01-20 新型杂环化合物

Country Status (5)

Country Link
US (1) US20220396565A1 (https=)
EP (1) EP4093734A1 (https=)
JP (1) JP7715715B2 (https=)
CN (1) CN114981259B (https=)
WO (1) WO2021148420A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4211116B1 (en) * 2020-09-07 2024-08-07 F. Hoffmann-La Roche AG Novel heterocyclic antibiotics
JP2024506021A (ja) * 2021-02-07 2024-02-08 エフ． ホフマン－ラ ロシュ アーゲー 新規ヘテロアリール置換イミダゾール誘導体
CN117715892A (zh) * 2021-07-06 2024-03-15 豪夫迈·罗氏有限公司 用于治疗细菌感染的季铵阳离子取代化合物
JP2024525793A (ja) * 2021-07-15 2024-07-12 エフ． ホフマン－ラ ロシュ アーゲー イミダゾール誘導体及びその抗生物質としての使用
JP2025508473A (ja) * 2022-02-25 2025-03-26 エフ． ホフマン－ラ ロシュ アーゲー 両性イオン性抗菌化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001344A (zh) * 2014-04-17 2017-08-01 诺丁汉大学 用于治疗病症的哌嗪衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849660B1 (en) * 2000-08-01 2005-02-01 Isis Pharmaceuticals, Inc. Antimicrobial biaryl compounds
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
CA3068305A1 (en) * 2017-06-29 2019-01-03 Rigel Pharmaceuticals, Inc. Kinase inhibitors and methods for making and using
US10471045B2 (en) * 2017-07-21 2019-11-12 The University Of Hong Kong Compounds and methods for the treatment of microbial infections
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
CN113164771A (zh) * 2018-12-17 2021-07-23 豪夫迈·罗氏有限公司 咪唑并吡嗪衍生物作为抗菌剂
WO2020182648A1 (en) * 2019-03-08 2020-09-17 F. Hoffmann-La Roche Ag Novel imidazole-pyrazole derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001344A (zh) * 2014-04-17 2017-08-01 诺丁汉大学 用于治疗病症的哌嗪衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Fabrizio Micheli等.Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: A new class of Neuropeptide S antagonists.Bioorganic & Medicinal Chemistry Letters.2010,第20卷7308–7311. *

Also Published As

Publication number Publication date
WO2021148420A1 (en) 2021-07-29
EP4093734A1 (en) 2022-11-30
US20220396565A1 (en) 2022-12-15
JP2023510971A (ja) 2023-03-15
CN114981259A (zh) 2022-08-30
JP7715715B2 (ja) 2025-07-30

Similar Documents

Publication Publication Date Title
CN114981259B (zh) 新型杂环化合物
US11390604B2 (en) Imidazole-pyrazole derivatives
JP7823030B2 (ja) 抗菌薬としてのイミダゾール－ピラゾール誘導体
JP2022513851A (ja) 抗菌剤としてのイミダゾピラジン誘導体
CN117715892A (zh) 用于治疗细菌感染的季铵阳离子取代化合物
JP7815147B2 (ja) 新規イミダゾピラジン誘導体
CN116096709A (zh) 新型杂环抗生素
JP7830431B2 (ja) 抗菌特性を有するイミダゾール－ピラゾール誘導体
JP7771084B2 (ja) 抗菌８－フェニルアミノ－３－（ピラゾール－４－イル）イミダゾ［１，２－ａ］ピラジン誘導体
JP2022513937A (ja) 抗菌剤としてのイミダゾピラジン誘導体
CN116829546A (zh) 新型杂芳基取代的咪唑衍生物
HK40078454A (en) Novel heterocyclic compounds
HK40085832A (en) Novel heterocyclic antibiotics
HK40078454B (zh) 新型杂环化合物
CN118119609A (zh) 咪唑衍生物及其作为抗生素的用途
HK40084728A (en) Imidazole-pyrazole derivatives as antibacterials
HK40084732A (en) Novel imidazopyrazine derivatives

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40078454

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant