JP7698631B2 - 核酸オリゴマーの製造方法 - Google Patents

核酸オリゴマーの製造方法 Download PDF

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Publication number
JP7698631B2
JP7698631B2 JP2022510762A JP2022510762A JP7698631B2 JP 7698631 B2 JP7698631 B2 JP 7698631B2 JP 2022510762 A JP2022510762 A JP 2022510762A JP 2022510762 A JP2022510762 A JP 2022510762A JP 7698631 B2 JP7698631 B2 JP 7698631B2
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Japan
Prior art keywords
group
formula
nucleic acid
dichloroacetic acid
formaldehyde
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JP2022510762A
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English (en)
Japanese (ja)
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JPWO2021193954A1 (https=
Inventor
雄樹 田中
俊史 加納
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Publication of JPWO2021193954A1 publication Critical patent/JPWO2021193954A1/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C07C51/46—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation by azeotropic distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Saccharide Compounds (AREA)
JP2022510762A 2020-03-27 2021-03-26 核酸オリゴマーの製造方法 Active JP7698631B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020058880 2020-03-27
JP2020058880 2020-03-27
PCT/JP2021/013023 WO2021193954A1 (ja) 2020-03-27 2021-03-26 核酸オリゴマーの製造方法

Publications (2)

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JPWO2021193954A1 JPWO2021193954A1 (https=) 2021-09-30
JP7698631B2 true JP7698631B2 (ja) 2025-06-25

Family

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Family Applications (1)

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JP2022510762A Active JP7698631B2 (ja) 2020-03-27 2021-03-26 核酸オリゴマーの製造方法

Country Status (6)

Country Link
US (1) US12522629B2 (https=)
EP (1) EP4130018A4 (https=)
JP (1) JP7698631B2 (https=)
KR (1) KR20220160010A (https=)
CN (1) CN115335387A (https=)
WO (1) WO2021193954A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117980285A (zh) * 2021-09-28 2024-05-03 住友化学株式会社 纯化二氯乙酸的制造方法
CN116333007B (zh) * 2021-12-23 2025-06-03 中国科学院化学研究所 一种基于点击化学的光响应性环形rna合成方法及其应用

Citations (5)

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WO2012017919A1 (ja) 2010-08-03 2012-02-09 株式会社ボナック 含窒素脂環式骨格を有する一本鎖核酸分子
WO2013103146A1 (ja) 2012-01-07 2013-07-11 株式会社ボナック アミノ酸骨格を有する一本鎖核酸分子
WO2016158809A1 (ja) 2015-03-27 2016-10-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
WO2017131237A1 (ja) 2016-01-30 2017-08-03 株式会社ボナック 人工単一ガイドｒｎａ及びその用途
WO2019189722A1 (ja) 2018-03-30 2019-10-03 東レ株式会社 ヘアピン型一本鎖ｒｎａ分子の製造方法

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US7273933B1 (en) 1998-02-26 2007-09-25 Isis Pharmaceuticals, Inc. Methods for synthesis of oligonucleotides
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
WO2011005595A2 (en) * 2009-06-24 2011-01-13 Alios Biopharma, Inc. 2-5a analogs and their methods of use
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
MX351566B (es) * 2011-06-21 2017-10-19 Akzo Nobel Chemicals Int Bv Proceso para separar acido monocloroacetico y acido dicloroacetico mediante destilacion extractiva.
MX370398B (es) * 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
HUE051986T2 (hu) * 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3328337B1 (en) 2015-07-31 2022-08-17 The Procter & Gamble Company Package of absorbent articles utilizing a shaped nonwoven
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
KR102670605B1 (ko) 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
US20220325309A1 (en) 2019-08-08 2022-10-13 Sumitomo Chemical Company, Limited Method for producing nucleic acid molecule

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012017919A1 (ja) 2010-08-03 2012-02-09 株式会社ボナック 含窒素脂環式骨格を有する一本鎖核酸分子
WO2013103146A1 (ja) 2012-01-07 2013-07-11 株式会社ボナック アミノ酸骨格を有する一本鎖核酸分子
WO2016158809A1 (ja) 2015-03-27 2016-10-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
WO2017131237A1 (ja) 2016-01-30 2017-08-03 株式会社ボナック 人工単一ガイドｒｎａ及びその用途
WO2019189722A1 (ja) 2018-03-30 2019-10-03 東レ株式会社 ヘアピン型一本鎖ｒｎａ分子の製造方法

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Beilstein Journal of Organic Chemistry，2017年，13，1368-1387
Nucleic Acids Research，1996年，24，3048-3052
Nucleic Acids Research，1996年，24，3053-3058

Also Published As

Publication number Publication date
US20230167152A1 (en) 2023-06-01
EP4130018A1 (en) 2023-02-08
KR20220160010A (ko) 2022-12-05
CN115335387A (zh) 2022-11-11
JPWO2021193954A1 (https=) 2021-09-30
WO2021193954A1 (ja) 2021-09-30
EP4130018A4 (en) 2024-04-17
US12522629B2 (en) 2026-01-13

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