JP7697954B2 - Kv1.3カリウムシェーカーチャネル遮断薬としてのアリールメチレン芳香族化合物 - Google Patents

Kv1.3カリウムシェーカーチャネル遮断薬としてのアリールメチレン芳香族化合物 Download PDF

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JP7697954B2
JP7697954B2 JP2022546591A JP2022546591A JP7697954B2 JP 7697954 B2 JP7697954 B2 JP 7697954B2 JP 2022546591 A JP2022546591 A JP 2022546591A JP 2022546591 A JP2022546591 A JP 2022546591A JP 7697954 B2 JP7697954 B2 JP 7697954B2
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mmol
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optionally substituted
cr6r7
dichloro
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JP2022552445A (ja
JP2022552445A5 (enExample
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ジョルダネット,ファブリツィオ
エステルガールド イェンセン,モルテン
ジョギーニ,ビシュワナス
ジョン スノウ,ロジャー
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ディー.イー.ショウ リサーチ,エルエルシー
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516925A (ja) 1996-07-31 2000-12-19 ブリストル―マイヤーズ スクイブ カンパニー カリウムチャンネル調節物質であるジフェニルヘテロ環化合物
JP2002501912A (ja) 1998-01-29 2002-01-22 ブリストル−マイヤーズ スクイブ カンパニー ジアリール1、3、4−オキサジアゾロンのベンゾエート誘導体
JP2012500835A (ja) 2008-08-29 2012-01-12 ゼンション・リミテッド 新規なカリウムチャネルブロッカー
JP2016074689A (ja) 2009-06-04 2016-05-12 日本たばこ産業株式会社 カリウムチャネル阻害剤として有用なジヒドロインドールおよびテトラヒドロイソキノリン誘導体

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
CH540009A (de) * 1970-07-23 1973-09-28 Ciba Geigy Ag Verwendung von Monohydroxyphenylcarbinolen zum antimikrobiellen Ausrüsten bzw. zum Schützen von textilen Materialien gegen schädliche Mikroorganismen
JPH07309837A (ja) * 1993-04-28 1995-11-28 Takeda Chem Ind Ltd ピリジン誘導体、その製造法および剤
JPH09278757A (ja) * 1996-04-15 1997-10-28 Takeda Chem Ind Ltd ヒドラゾン誘導体および剤
EP1838690A2 (en) * 2004-12-21 2007-10-03 Devgen N.V. Compounds with kv4 ion channel activity
AU2008307075B2 (en) * 2007-10-04 2012-05-17 Bionomics Limited Novel aryl potassium channel blockers and uses thereof
KR20130100300A (ko) * 2010-08-27 2013-09-10 그뤼넨탈 게엠베하 Kcnq2/3 조절제로서의 치환된 2-옥시-퀴놀린-3-카복스아미드
EP2970153B1 (en) * 2013-03-13 2018-02-21 The United States of America, as represented by The Secretary of The Army, on behalf of Walter Reed Army Institute of Research Triazine compounds and compositions thereof and methods for treating malaria and chemoprophylaxis
HRP20210472T1 (hr) * 2015-08-27 2021-05-14 Pfizer Inc. Biciklički kondenzirani heteroarilni ili arilni spojevi kao modulatori irak4
EP3490542A4 (en) * 2016-07-26 2020-07-08 Flagship Pioneering Innovations V, Inc. NEUROMODULATION COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF CANCER BY MODULATION OF AN ANTI-CANCER RESPONSE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516925A (ja) 1996-07-31 2000-12-19 ブリストル―マイヤーズ スクイブ カンパニー カリウムチャンネル調節物質であるジフェニルヘテロ環化合物
JP2002501912A (ja) 1998-01-29 2002-01-22 ブリストル−マイヤーズ スクイブ カンパニー ジアリール1、3、4−オキサジアゾロンのベンゾエート誘導体
JP2012500835A (ja) 2008-08-29 2012-01-12 ゼンション・リミテッド 新規なカリウムチャネルブロッカー
JP2016074689A (ja) 2009-06-04 2016-05-12 日本たばこ産業株式会社 カリウムチャネル阻害剤として有用なジヒドロインドールおよびテトラヒドロイソキノリン誘導体

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