JP7675094B2 - トリアゾロン化合物 - Google Patents

トリアゾロン化合物 Download PDF

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Publication number
JP7675094B2
JP7675094B2 JP2022558347A JP2022558347A JP7675094B2 JP 7675094 B2 JP7675094 B2 JP 7675094B2 JP 2022558347 A JP2022558347 A JP 2022558347A JP 2022558347 A JP2022558347 A JP 2022558347A JP 7675094 B2 JP7675094 B2 JP 7675094B2
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JP
Japan
Prior art keywords
methyl
amino
pyrimidin
triazolo
pyridyl
Prior art date
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Active
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JP2022558347A
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English (en)
Japanese (ja)
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JP2023519362A5 (enExample
JP2023519362A (ja
Inventor
アルバート ブラウン，ジレス
メアリー リチャードソン，クリスティン
スチュアート コングリーブ，マイルズ
ポール，レベッカ
フィリップ アンドリューズ，スティーブン
スティーブン メイソン，ジョナサン
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Nxera Pharma UK Ltd
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Nxera Pharma UK Ltd
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Publication of JP2023519362A publication Critical patent/JP2023519362A/ja
Publication of JP2023519362A5 publication Critical patent/JP2023519362A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022558347A 2020-03-26 2021-03-25 トリアゾロン化合物 Active JP7675094B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062994908P 2020-03-26 2020-03-26
US62/994,908 2020-03-26
PCT/EP2021/057806 WO2021191378A1 (en) 2020-03-26 2021-03-25 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer

Publications (3)

Publication Number Publication Date
JP2023519362A JP2023519362A (ja) 2023-05-10
JP2023519362A5 JP2023519362A5 (enExample) 2024-04-01
JP7675094B2 true JP7675094B2 (ja) 2025-05-12

Family

ID=75339740

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022558347A Active JP7675094B2 (ja) 2020-03-26 2021-03-25 トリアゾロン化合物

Country Status (8)

Country Link
US (1) US20230271964A1 (enExample)
EP (1) EP4126872A1 (enExample)
JP (1) JP7675094B2 (enExample)
KR (1) KR20230049579A (enExample)
CN (1) CN115867282B (enExample)
AU (1) AU2021240344A1 (enExample)
CA (1) CA3176944A1 (enExample)
WO (1) WO2021191378A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20241731A1 (es) * 2022-02-01 2024-08-19 Lilly Co Eli Procesos para la preparacion de degradadores selectivos del receptor de estrogeno
AU2023252914A1 (en) 2022-04-13 2024-10-17 Arcus Biosciences, Inc. Combination therapy for treating trop-2 expressing cancers
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138734A1 (en) 2005-06-17 2006-12-28 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
JP2011513417A (ja) 2008-03-04 2011-04-28 シェーリング コーポレイション アデノシンＡ２ａ受容体アンタゴニストとして使用するための１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オンおよびピラゾロ［４，３−ｅ］−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オン化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2038285B1 (en) 2006-06-26 2010-02-17 Schering Corporation Adenosine a2a receptor antagonists
CN103261202B (zh) 2010-09-24 2016-01-20 阿迪维纳斯疗法有限公司 作为腺苷受体拮抗剂的稠合三环化合物
EA201792205A1 (ru) 2015-04-03 2018-02-28 Инсайт Корпорейшн Гетероциклические соединения как ингибиторы lsd1
KR20190129851A (ko) 2017-03-16 2019-11-20 지앙수 헨그루이 메디슨 컴퍼니 리미티드 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138734A1 (en) 2005-06-17 2006-12-28 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
JP2011513417A (ja) 2008-03-04 2011-04-28 シェーリング コーポレイション アデノシンＡ２ａ受容体アンタゴニストとして使用するための１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オンおよびピラゾロ［４，３−ｅ］−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オン化合物

Also Published As

Publication number Publication date
EP4126872A1 (en) 2023-02-08
AU2021240344A1 (en) 2022-10-27
CA3176944A1 (en) 2021-09-30
CN115867282B (zh) 2025-05-27
CN115867282A (zh) 2023-03-28
KR20230049579A (ko) 2023-04-13
US20230271964A1 (en) 2023-08-31
JP2023519362A (ja) 2023-05-10
WO2021191378A1 (en) 2021-09-30

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