JP7672636B2 - 間葉系幹細胞の動員活性を有するペプチド - Google Patents

間葉系幹細胞の動員活性を有するペプチド Download PDF

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JP7672636B2
JP7672636B2 JP2022511147A JP2022511147A JP7672636B2 JP 7672636 B2 JP7672636 B2 JP 7672636B2 JP 2022511147 A JP2022511147 A JP 2022511147A JP 2022511147 A JP2022511147 A JP 2022511147A JP 7672636 B2 JP7672636 B2 JP 7672636B2
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seq
amino acid
acid sequence
peptide
peptide consisting
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JPWO2021201260A1 (https=
Inventor
克人 玉井
敬史 新保
尊彦 山崎
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StemRIM Inc
University of Osaka NUC
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Osaka University NUC
StemRIM Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022511147A 2020-04-03 2021-04-02 間葉系幹細胞の動員活性を有するペプチド Active JP7672636B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020067570 2020-04-03
JP2020067570 2020-04-03
PCT/JP2021/014253 WO2021201260A1 (ja) 2020-04-03 2021-04-02 間葉系幹細胞の動員活性を有するペプチド

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JPWO2021201260A1 JPWO2021201260A1 (https=) 2021-10-07
JP7672636B2 true JP7672636B2 (ja) 2025-05-08

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US (1) US20230241159A1 (https=)
EP (1) EP4144359A4 (https=)
JP (1) JP7672636B2 (https=)
CN (1) CN115697372A (https=)
BR (1) BR112022019434A2 (https=)
CA (1) CA3178719A1 (https=)
IL (1) IL296982B2 (https=)
WO (1) WO2021201260A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3556378B1 (en) 2017-01-27 2025-03-12 StemRIM Inc. Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure
US20210024594A1 (en) 2018-02-08 2021-01-28 StemRIM Inc. Therapeutic Agent for Psoriasis
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133939A1 (ja) 2008-04-30 2009-11-05 株式会社ジェノミックス 末梢循環への骨髄由来多能性幹細胞動員薬
WO2011052668A1 (ja) 2009-10-28 2011-05-05 株式会社ジェノミックス 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤
WO2018186480A1 (ja) 2017-04-07 2018-10-11 株式会社ステムリム 線維性疾患の治療薬
WO2019107530A1 (ja) 2017-12-01 2019-06-06 株式会社ステムリム 炎症性腸疾患の治療薬
WO2020158924A1 (ja) 2019-01-31 2020-08-06 国立大学法人大阪大学 母児間免疫寛容を誘導する方法
JP7405345B2 (ja) 2018-10-05 2023-12-26 株式会社ステムリム 間葉系幹細胞の動員活性を有するペプチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3358011T (pt) * 2011-04-26 2020-04-23 Univ Osaka Péptido para induzir a regeneração de um tecido e a sua utilização
CA3059544A1 (en) * 2017-04-25 2018-11-01 Shionogi & Co., Ltd. Peptide for inducing regeneration of tissue, and use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133939A1 (ja) 2008-04-30 2009-11-05 株式会社ジェノミックス 末梢循環への骨髄由来多能性幹細胞動員薬
WO2011052668A1 (ja) 2009-10-28 2011-05-05 株式会社ジェノミックス 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤
WO2018186480A1 (ja) 2017-04-07 2018-10-11 株式会社ステムリム 線維性疾患の治療薬
WO2019107530A1 (ja) 2017-12-01 2019-06-06 株式会社ステムリム 炎症性腸疾患の治療薬
JP7405345B2 (ja) 2018-10-05 2023-12-26 株式会社ステムリム 間葉系幹細胞の動員活性を有するペプチド
WO2020158924A1 (ja) 2019-01-31 2020-08-06 国立大学法人大阪大学 母児間免疫寛容を誘導する方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
YAMAOKA S. et al.，Systemic delivery of HMGB1 peptide ameliorates imiquimod-induced psoriasis-like dermatitis，Journal of Investigative Dermatology，2018年05月，138(5 Supplement)，p.S177,1043
何 彦霆,他4名，HMGB1 ameliorates inflammatory bowel disease by inducing circulating mesenchymal stem cells，第17回日本再生医療学会総会 プログラム抄録[online]retrived on 2019 Oct 21，2018年02月23日，O-34-2，retrived from the Internet,URL:http://www2.convention.co.jp/17jsrm/appli/から取得

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Publication number Publication date
CA3178719A1 (en) 2021-10-07
CN115697372A (zh) 2023-02-03
JPWO2021201260A1 (https=) 2021-10-07
US20230241159A1 (en) 2023-08-03
BR112022019434A2 (pt) 2022-12-06
IL296982B1 (en) 2025-12-01
IL296982A (en) 2022-12-01
WO2021201260A1 (ja) 2021-10-07
EP4144359A1 (en) 2023-03-08
EP4144359A4 (en) 2024-05-01
IL296982B2 (en) 2026-04-01

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