BR112022019434A2 - Peptídeo que tem atividade de mobilização de células-tronco mesenquimais - Google Patents

Peptídeo que tem atividade de mobilização de células-tronco mesenquimais

Info

Publication number
BR112022019434A2
BR112022019434A2 BR112022019434A BR112022019434A BR112022019434A2 BR 112022019434 A2 BR112022019434 A2 BR 112022019434A2 BR 112022019434 A BR112022019434 A BR 112022019434A BR 112022019434 A BR112022019434 A BR 112022019434A BR 112022019434 A2 BR112022019434 A2 BR 112022019434A2
Authority
BR
Brazil
Prior art keywords
peptide
mesenchymal stem
stem cell
cell mobilization
activity
Prior art date
Application number
BR112022019434A
Other languages
English (en)
Inventor
Tamai Katsuto
Shimbo Takashi
Yamazaki Takehiko
Original Assignee
Stemrim Inc
Univ Osaka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stemrim Inc, Univ Osaka filed Critical Stemrim Inc
Publication of BR112022019434A2 publication Critical patent/BR112022019434A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PEPTÍDEO QUE TEM ATIVIDADE DE MOBILIZAÇÃO DE CÉLULAS-TRONCO MESENQUIMAIS. A presente invenção refere-se a uma pluralidade de peptídeos, cada um consistindo em uma sequência parcial do peptídeo de sequência artificial "1r10" (fragmentos do peptídeo 1r10), o qual foi descoberto a partir de suas próprias pesquisas realizadas até o momento, investigaram se eles têm uma atividade de mobilização de células-tronco mesenquimais no sangue periférico e, como um resultado, descobriram que um fragmento do peptídeo 1r10 que tem uma sequência de aminoácidos específica mostra a atividade. Com base nesta descoberta, é fornecido um peptídeo que se acredita apresentar efeitos terapêuticos em várias doenças por meio de mobilização de células-tronco mesenquimais no sangue periférico.
BR112022019434A 2020-04-03 2021-04-02 Peptídeo que tem atividade de mobilização de células-tronco mesenquimais BR112022019434A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020067570 2020-04-03
PCT/JP2021/014253 WO2021201260A1 (ja) 2020-04-03 2021-04-02 間葉系幹細胞の動員活性を有するペプチド

Publications (1)

Publication Number Publication Date
BR112022019434A2 true BR112022019434A2 (pt) 2022-12-06

Family

ID=77929177

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022019434A BR112022019434A2 (pt) 2020-04-03 2021-04-02 Peptídeo que tem atividade de mobilização de células-tronco mesenquimais

Country Status (8)

Country Link
US (1) US20230241159A1 (pt)
EP (1) EP4144359A4 (pt)
JP (1) JPWO2021201260A1 (pt)
CN (1) CN115697372A (pt)
BR (1) BR112022019434A2 (pt)
CA (1) CA3178719A1 (pt)
IL (1) IL296982A (pt)
WO (1) WO2021201260A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3051825A1 (en) 2017-01-27 2018-08-02 StemRIM Inc. Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519714C2 (ru) * 2008-04-30 2014-06-20 Дженомикс Ко., Лтд. Средство для вовлечения происходящей из костного мозга плюрипотентной стволовой клетки в периферический кровоток
KR20120135190A (ko) * 2009-10-28 2012-12-12 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 골수 간엽계 및/또는 다능성 줄기세포의 혈중 동원(動員)에 의한 조직 재생 촉진제
EP2703487B1 (en) * 2011-04-26 2018-06-27 Genomix Co., Ltd. Peptide for inducing regeneration of tissue and use thereof
US20200038486A1 (en) * 2017-04-07 2020-02-06 StemRIM Inc. Therapeutic medicine for fibrous disease
MX2019012738A (es) * 2017-04-25 2020-02-07 Shionogi & Co Peptido para inducir la regeneracion de tejido, y uso del mismo.
US11298403B2 (en) * 2017-12-01 2022-04-12 StemRIM Inc. Therapeutic agent for inflammatory bowel disease
US20220009976A1 (en) * 2018-10-05 2022-01-13 StemRIM Inc. Peptide Possessing Mesenchymal-Stem-Cell Mobilizing Activity
WO2020158924A1 (ja) * 2019-01-31 2020-08-06 国立大学法人大阪大学 母児間免疫寛容を誘導する方法

Also Published As

Publication number Publication date
IL296982A (en) 2022-12-01
CA3178719A1 (en) 2021-10-07
WO2021201260A1 (ja) 2021-10-07
CN115697372A (zh) 2023-02-03
EP4144359A1 (en) 2023-03-08
EP4144359A4 (en) 2024-05-01
JPWO2021201260A1 (pt) 2021-10-07
US20230241159A1 (en) 2023-08-03

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