JP7662644B2 - 化合物 - Google Patents

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Publication number
JP7662644B2
JP7662644B2 JP2022537022A JP2022537022A JP7662644B2 JP 7662644 B2 JP7662644 B2 JP 7662644B2 JP 2022537022 A JP2022537022 A JP 2022537022A JP 2022537022 A JP2022537022 A JP 2022537022A JP 7662644 B2 JP7662644 B2 JP 7662644B2
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Prior art keywords
benzo
methoxy
ethane
imidazole
diyl
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Japanese (ja)
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JP2023506899A5 (enExample
JP2023506899A (ja
Inventor
ベンジャミン ジョゼフ モロー，
ジョナサン グラント ヒューバート，
ポール アンソニー スタップル，
ミシェル アン カメリーノ，
マシュー ロイド デニス，
アンソニー ニコラス クッズーペ，
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シーティーエックスティー・ピーティーワイ・リミテッド
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Priority claimed from GBGB1918761.6A external-priority patent/GB201918761D0/en
Priority claimed from GBGB2009944.6A external-priority patent/GB202009944D0/en
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Publication of JP2023506899A publication Critical patent/JP2023506899A/ja
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Priority to JP2025005355A priority Critical patent/JP2025061311A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022537022A 2019-12-18 2020-12-18 化合物 Active JP7662644B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025005355A JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1918761.6A GB201918761D0 (en) 2019-12-18 2019-12-18 Compounds
GB1918761.6 2019-12-18
GB2009944.6 2020-06-30
GBGB2009944.6A GB202009944D0 (en) 2020-06-30 2020-06-30 Compounds
PCT/AU2020/051394 WO2021119753A1 (en) 2019-12-18 2020-12-18 Compounds

Related Child Applications (1)

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JP2025005355A Division JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

Publications (3)

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JP2023506899A JP2023506899A (ja) 2023-02-20
JP2023506899A5 JP2023506899A5 (enExample) 2023-12-12
JP7662644B2 true JP7662644B2 (ja) 2025-04-15

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JP2025005355A Pending JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

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US (1) US12415785B2 (enExample)
EP (1) EP4077318B1 (enExample)
JP (2) JP7662644B2 (enExample)
CN (1) CN114981265B (enExample)
AU (1) AU2020409429A1 (enExample)
CA (1) CA3164751A1 (enExample)
ES (1) ES3056923T3 (enExample)
WO (1) WO2021119753A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022266711A1 (en) * 2021-06-23 2022-12-29 Aculeus Therapeutics Pty Ltd Substituted amidobenzimidazole dimers as sting modulators
CN113603661B (zh) * 2021-08-11 2024-04-09 沈阳药科大学 (s)-5-氟-3-甲基异苯并呋喃-3-酮的合成方法
CN114349662A (zh) * 2022-01-20 2022-04-15 杭州裕普润生物科技有限公司 一种溴化苄的制备方法
CN114671747B (zh) * 2022-04-08 2024-10-29 浙江永太科技股份有限公司 一种4-氯-2-氟苯甲醛的合成方法
EP4615962A1 (en) * 2022-11-09 2025-09-17 Kathleen E. Clarence-Smith Pharmaceutical combination for the treatment of multiple myeloma, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma
WO2024174863A1 (zh) * 2023-02-22 2024-08-29 深圳众格生物科技有限公司 Sting激动剂及其制备方法和医药用途

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