JP7661533B2 - Nrf2活性化作用を有する含窒素複素環化合物 - Google Patents
Nrf2活性化作用を有する含窒素複素環化合物 Download PDFInfo
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- JP7661533B2 JP7661533B2 JP2023572495A JP2023572495A JP7661533B2 JP 7661533 B2 JP7661533 B2 JP 7661533B2 JP 2023572495 A JP2023572495 A JP 2023572495A JP 2023572495 A JP2023572495 A JP 2023572495A JP 7661533 B2 JP7661533 B2 JP 7661533B2
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- benzoxazin
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C07D—HETEROCYCLIC COMPOUNDS
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| WO2024262491A1 (ja) * | 2023-06-19 | 2024-12-26 | 中外製薬株式会社 | Nrf2活性化作用を有する含窒素複素環化合物の結晶 |
| CN118221551A (zh) * | 2024-04-10 | 2024-06-21 | 南京艾康生物科技有限公司 | 4-甲酰苄基氨基甲酸叔丁酯的制备方法 |
| CN119684220A (zh) * | 2024-12-13 | 2025-03-25 | 江苏宝众宝达药业股份有限公司 | 一种(2r,5r)-1,2,5-三甲基哌嗪的制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2016036633A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| CN110294744A (zh) | 2018-03-21 | 2019-10-01 | 中国医学科学院药物研究所 | Gpr40受体激动剂、其制法和其药物组合物与用途 |
| WO2020084300A1 (en) | 2018-10-22 | 2020-04-30 | C4X Discovery Limited | Therapeutic compounds |
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| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| EP2440204B1 (en) * | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| US20140256767A1 (en) * | 2011-10-31 | 2014-09-11 | The Broad Institute, Inc. | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
| AR096046A1 (es) | 2013-04-24 | 2015-12-02 | Abbvie Inc | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
| EP3250198A1 (en) | 2014-12-04 | 2017-12-06 | Biogen MA Inc. | Multiple sclerosis treatment regimen using dimethyl fumarate |
| US20190389836A1 (en) * | 2017-01-30 | 2019-12-26 | Biogen Ma Inc. | Nrf2 activator |
| JP7602469B2 (ja) | 2019-02-15 | 2024-12-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Nrf2活性剤としてのヒドロキシピリドキシアゼピン |
| GB202005852D0 (en) * | 2020-04-22 | 2020-06-03 | C4X Discovery Ltd | Therapeutic compounds |
| GB202005863D0 (en) * | 2020-04-22 | 2020-06-03 | C4X Discovery Ltd | Therapeutic compounds |
| CN114507181B (zh) * | 2020-11-17 | 2024-03-26 | 中国医学科学院药物研究所 | 含5-取代四氢异喹啉的丙酸类化合物、其药物组合物和应用 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2016036633A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| CN110294744A (zh) | 2018-03-21 | 2019-10-01 | 中国医学科学院药物研究所 | Gpr40受体激动剂、其制法和其药物组合物与用途 |
| WO2020084300A1 (en) | 2018-10-22 | 2020-04-30 | C4X Discovery Limited | Therapeutic compounds |
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| CA3246898A1 (en) | 2025-02-27 |
| IL312793A (en) | 2024-07-01 |
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| CL2024001687A1 (es) | 2024-11-29 |
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| ZA202406044B (en) | 2026-01-28 |
| CR20240325A (es) | 2024-11-22 |
| CO2024007707A2 (es) | 2024-09-19 |
| EP4446312A4 (en) | 2025-11-19 |
| AR128216A1 (es) | 2024-04-10 |
| MX2024008480A (es) | 2024-07-15 |
| JPWO2023132369A1 (https=) | 2023-07-13 |
| JP2025106358A (ja) | 2025-07-15 |
| AU2023204960A1 (en) | 2024-05-16 |
| CN118488944A (zh) | 2024-08-13 |
| WO2023132369A1 (ja) | 2023-07-13 |
| PE20241779A1 (es) | 2024-09-03 |
| KR20240133727A (ko) | 2024-09-04 |
| US20250171457A1 (en) | 2025-05-29 |
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