KR20240133727A - Nrf2 활성화 작용을 갖는 함질소 헤테로환 화합물 - Google Patents
Nrf2 활성화 작용을 갖는 함질소 헤테로환 화합물 Download PDFInfo
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- KR20240133727A KR20240133727A KR1020247025555A KR20247025555A KR20240133727A KR 20240133727 A KR20240133727 A KR 20240133727A KR 1020247025555 A KR1020247025555 A KR 1020247025555A KR 20247025555 A KR20247025555 A KR 20247025555A KR 20240133727 A KR20240133727 A KR 20240133727A
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| CN118221551A (zh) * | 2024-04-10 | 2024-06-21 | 南京艾康生物科技有限公司 | 4-甲酰苄基氨基甲酸叔丁酯的制备方法 |
| CN119684220A (zh) * | 2024-12-13 | 2025-03-25 | 江苏宝众宝达药业股份有限公司 | 一种(2r,5r)-1,2,5-三甲基哌嗪的制备方法 |
Citations (4)
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|---|---|---|---|---|
| WO1999065478A1 (en) | 1998-06-19 | 1999-12-23 | Trustees Of Dartmouth College | Therapeutic compositions and methods of use |
| WO2014176415A1 (en) | 2013-04-24 | 2014-10-30 | Abbvie Inc. | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| WO2016090154A1 (en) | 2014-12-04 | 2016-06-09 | Biogen Ma Inc. | Multiple sclerosis treatment regimen using dimethyl fumarate |
| WO2020165776A1 (en) | 2019-02-15 | 2020-08-20 | Glaxosmithkline Intellectual Property Development Limited | Hydroxypyridoxazepines as nrf2 activators |
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| EP2440204B1 (en) * | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| US20140256767A1 (en) * | 2011-10-31 | 2014-09-11 | The Broad Institute, Inc. | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
| US9403774B2 (en) * | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US10568876B2 (en) * | 2014-09-05 | 2020-02-25 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| US20190389836A1 (en) * | 2017-01-30 | 2019-12-26 | Biogen Ma Inc. | Nrf2 activator |
| CN110294744A (zh) * | 2018-03-21 | 2019-10-01 | 中国医学科学院药物研究所 | Gpr40受体激动剂、其制法和其药物组合物与用途 |
| MX2021004566A (es) * | 2018-10-22 | 2021-06-08 | C4X Discovery Ltd | Compuestos terapeuticos. |
| GB202005852D0 (en) * | 2020-04-22 | 2020-06-03 | C4X Discovery Ltd | Therapeutic compounds |
| GB202005863D0 (en) * | 2020-04-22 | 2020-06-03 | C4X Discovery Ltd | Therapeutic compounds |
| CN114507181B (zh) * | 2020-11-17 | 2024-03-26 | 中国医学科学院药物研究所 | 含5-取代四氢异喹啉的丙酸类化合物、其药物组合物和应用 |
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2025
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999065478A1 (en) | 1998-06-19 | 1999-12-23 | Trustees Of Dartmouth College | Therapeutic compositions and methods of use |
| WO2014176415A1 (en) | 2013-04-24 | 2014-10-30 | Abbvie Inc. | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| WO2016090154A1 (en) | 2014-12-04 | 2016-06-09 | Biogen Ma Inc. | Multiple sclerosis treatment regimen using dimethyl fumarate |
| WO2020165776A1 (en) | 2019-02-15 | 2020-08-20 | Glaxosmithkline Intellectual Property Development Limited | Hydroxypyridoxazepines as nrf2 activators |
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| CA3246898A1 (en) | 2025-02-27 |
| IL312793A (en) | 2024-07-01 |
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| JP7661533B2 (ja) | 2025-04-14 |
| CL2024001687A1 (es) | 2024-11-29 |
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| US20250084093A1 (en) | 2025-03-13 |
| ZA202406044B (en) | 2026-01-28 |
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| JP2025106358A (ja) | 2025-07-15 |
| AU2023204960A1 (en) | 2024-05-16 |
| CN118488944A (zh) | 2024-08-13 |
| WO2023132369A1 (ja) | 2023-07-13 |
| PE20241779A1 (es) | 2024-09-03 |
| US20250171457A1 (en) | 2025-05-29 |
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