JP7609359B2 - 超閾値低周波数電気刺激による神経系ブロック - Google Patents

超閾値低周波数電気刺激による神経系ブロック Download PDF

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JP7609359B2
JP7609359B2 JP2021577539A JP2021577539A JP7609359B2 JP 7609359 B2 JP7609359 B2 JP 7609359B2 JP 2021577539 A JP2021577539 A JP 2021577539A JP 2021577539 A JP2021577539 A JP 2021577539A JP 7609359 B2 JP7609359 B2 JP 7609359B2
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nerve
electrical stimulation
minutes
intensity
stimulation
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JP2022539172A (ja
JP2022539172A5 (https=
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チャンフン、タイ
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University of Pittsburgh
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University of Pittsburgh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36178—Burst or pulse train parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Electrotherapy Devices (AREA)
JP2021577539A 2019-07-03 2020-06-30 超閾値低周波数電気刺激による神経系ブロック Active JP7609359B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962870230P 2019-07-03 2019-07-03
US62/870,230 2019-07-03
PCT/US2020/040288 WO2021003151A1 (en) 2019-07-03 2020-06-30 Neural block by super-threshold low frequency electrical stimulation

Publications (3)

Publication Number Publication Date
JP2022539172A JP2022539172A (ja) 2022-09-07
JP2022539172A5 JP2022539172A5 (https=) 2023-05-02
JP7609359B2 true JP7609359B2 (ja) 2025-01-07

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JP2021577539A Active JP7609359B2 (ja) 2019-07-03 2020-06-30 超閾値低周波数電気刺激による神経系ブロック

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Country Link
US (1) US20220395686A1 (https=)
EP (1) EP3993865A4 (https=)
JP (1) JP7609359B2 (https=)
KR (1) KR102944729B1 (https=)
CN (1) CN114286705A (https=)
AU (1) AU2020300506B2 (https=)
BR (1) BR112021026805A2 (https=)
CA (1) CA3145807A1 (https=)
WO (1) WO2021003151A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
EP4103267B1 (en) 2020-02-11 2025-06-04 Neuros Medical, Inc. System for quantifying qualitative patient-reported data sets
JP2024513688A (ja) 2021-03-12 2024-03-27 アンバー セラピューティクス リミテッド 失禁制御のためのデバイス、システム、および方法
AU2022366677A1 (en) * 2021-10-14 2024-04-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Sacral neuromodulation for bowel and sexual functions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130289647A1 (en) 2008-04-02 2013-10-31 Case Westem Reserve University System and method of bladder and sphincter control
WO2015109023A1 (en) 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Depletion block to block nerve communication
WO2015179744A1 (en) 2014-05-23 2015-11-26 ElectroCore, LLC Systems and methods for vagal nerve stimulation
WO2017021909A1 (en) 2015-08-03 2017-02-09 Glaxosmithkline Intellectual Property Development Limited Neuromodulation device
WO2017127582A1 (en) 2016-01-19 2017-07-27 Incube Labs, Llc Systems and methods for patient-enabled bladder control

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8626302B2 (en) * 1998-06-03 2014-01-07 Spr Therapeutics, Llc Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US6393323B1 (en) * 2000-01-31 2002-05-21 Mcgill University Electronic stimulator implant for modulating and synchronizing bladder and sphincter function
US6928320B2 (en) * 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US7328069B2 (en) * 2002-09-06 2008-02-05 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves
US20050070970A1 (en) * 2003-09-29 2005-03-31 Knudson Mark B. Movement disorder stimulation with neural block
CA2553901C (en) * 2004-01-22 2015-01-20 Rehabtronics Inc. Method of routing electrical current to bodily tissues via implanted passive conductors
US20070073354A1 (en) * 2005-09-26 2007-03-29 Knudson Mark B Neural blocking therapy
US9020597B2 (en) * 2008-11-12 2015-04-28 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
US8805510B2 (en) * 2007-08-02 2014-08-12 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade
US8195287B2 (en) * 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
CN102307618B (zh) * 2008-12-09 2014-03-12 内费拉有限公司 泌尿系统的刺激
US9174045B2 (en) * 2009-03-20 2015-11-03 ElectroCore, LLC Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
US10195434B2 (en) * 2012-06-15 2019-02-05 Case Western Reserve University Treatment of pain using electrical nerve conduction block
EP2870979B1 (en) * 2013-11-08 2021-01-06 Nuvectra Corporation Implantable medical lead for stimulation of multiple nerves
MX389895B (es) * 2014-09-12 2025-03-20 Neuros Medical Inc Electrodo tipo cuff de nervios para neuromodulación en troncos nerviosos grandes de humano.
CN105310680B (zh) * 2015-05-14 2018-03-27 南京神桥医疗器械有限公司 一种植入式神经信号阻断装置
EP3297720B1 (en) * 2015-05-21 2022-11-02 EBT Medical, Inc. Systems for treatment of urinary dysfunction
CN106621032A (zh) * 2015-10-28 2017-05-10 精能医学股份有限公司 电刺激器及应用其的刺激方法及电刺激系统
WO2017096007A1 (en) * 2015-12-03 2017-06-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Device and method for nerve block by local cooling to room temperature
US20170348540A1 (en) * 2016-06-02 2017-12-07 Boston Scientific Neuromodulation Corporation Priming-assisted neuromodulation therapy
US10492713B2 (en) * 2016-06-03 2019-12-03 The Cleveland Clinic Foundation Systems and methods for monitoring a depth of neuromuscular blockade
WO2018033111A1 (en) * 2016-08-17 2018-02-22 Tam Pui Ling Non-invasive device and method for stimulating vulvar tissues and pelvic floor muscles for treating and improving dysfunction or disorders and probe unit used therefor
EP3503968A4 (en) * 2016-08-25 2020-05-06 Virender K. Sharma SYSTEM AND METHOD FOR ELECTRICALLY STIMULATING ANOREECTAL STRUCTURES FOR TREATING DYSFUNCTION OF THE URINARY TRACT

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130289647A1 (en) 2008-04-02 2013-10-31 Case Westem Reserve University System and method of bladder and sphincter control
WO2015109023A1 (en) 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Depletion block to block nerve communication
JP2017502786A (ja) 2014-01-17 2017-01-26 カーディアック ペースメイカーズ， インコーポレイテッド 神経連絡をブロックする枯渇ブロック
WO2015179744A1 (en) 2014-05-23 2015-11-26 ElectroCore, LLC Systems and methods for vagal nerve stimulation
JP2017519549A (ja) 2014-05-23 2017-07-20 エレクトロコア リミテッド ライアビリティ カンパニー 迷走神経刺激システム及び方法
WO2017021909A1 (en) 2015-08-03 2017-02-09 Glaxosmithkline Intellectual Property Development Limited Neuromodulation device
JP2018525092A (ja) 2015-08-03 2018-09-06 ガルバニ バイオエレクトロニクス リミテッド 神経調節デバイス
WO2017127582A1 (en) 2016-01-19 2017-07-27 Incube Labs, Llc Systems and methods for patient-enabled bladder control

Also Published As

Publication number Publication date
WO2021003151A1 (en) 2021-01-07
KR20220035140A (ko) 2022-03-21
KR102944729B1 (ko) 2026-03-30
JP2022539172A (ja) 2022-09-07
US20220395686A1 (en) 2022-12-15
EP3993865A1 (en) 2022-05-11
CA3145807A1 (en) 2021-01-07
BR112021026805A2 (pt) 2022-02-15
CN114286705A (zh) 2022-04-05
EP3993865A4 (en) 2023-07-19
AU2020300506A1 (en) 2022-01-27
AU2020300506B2 (en) 2025-09-04

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