JP7607872B2 - マイクロrna発現構築物及びその使用 - Google Patents

マイクロrna発現構築物及びその使用 Download PDF

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JP7607872B2
JP7607872B2 JP2020552746A JP2020552746A JP7607872B2 JP 7607872 B2 JP7607872 B2 JP 7607872B2 JP 2020552746 A JP2020552746 A JP 2020552746A JP 2020552746 A JP2020552746 A JP 2020552746A JP 7607872 B2 JP7607872 B2 JP 7607872B2
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sequence
mirna
expression construct
cells
mirna expression
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JPWO2019186274A5 (https=
JP2021519587A (ja
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カルルーハインツ クラウゼ,
フランシス ルーセ,
パトリック サルモン,
マルコ アレッサンドリーニ,
ロベルト シュペック,
シモーン ブレドル,
タファズワ ムランボ,
レニエ ミバラ,
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Hopitaux Universitaires De Geneve
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • AHUMAN NECESSITIES
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/421Immunoglobulin superfamily
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07K2319/00Fusion polypeptide
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020552746A 2018-03-30 2019-04-01 マイクロrna発現構築物及びその使用 Active JP7607872B2 (ja)

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Application Number Priority Date Filing Date Title
US201862650403P 2018-03-30 2018-03-30
US201862650387P 2018-03-30 2018-03-30
US62/650,387 2018-03-30
US62/650,403 2018-03-30
PCT/IB2019/000328 WO2019186274A2 (en) 2018-03-30 2019-04-01 Micro rna expression constructs and uses thereof

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JP2021519587A JP2021519587A (ja) 2021-08-12
JPWO2019186274A5 JPWO2019186274A5 (https=) 2022-04-11
JP2021519587A5 JP2021519587A5 (https=) 2022-04-11
JP7607872B2 true JP7607872B2 (ja) 2025-01-06

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EP (1) EP3775214A2 (https=)
JP (1) JP7607872B2 (https=)
CN (1) CN112105731B (https=)
AU (1) AU2019244479B2 (https=)
CA (1) CA3133899A1 (https=)
SG (1) SG11202009697RA (https=)
WO (1) WO2019186274A2 (https=)
ZA (1) ZA202006505B (https=)

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MX2023008115A (es) * 2021-01-11 2023-09-11 Precigen Inc Terapia con receptores quiméricos.
GB202106354D0 (en) * 2021-05-04 2021-06-16 Celyad S A Improved chimeric and engineered scaffolds doe multiplexed ingibitory RNA
GB202201927D0 (en) * 2022-02-14 2022-03-30 Kings College Artificial microrna construct
CN114774364B (zh) * 2022-04-26 2024-04-26 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其制备方法和应用
GB202206507D0 (en) 2022-05-04 2022-06-15 Antion Biosciences Sa Expression construct
KR20250158048A (ko) 2023-03-03 2025-11-05 아스널 바이오사이언시스, 인크. Psma 및 ca9을 표적으로 하는 시스템
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AU2019244479A1 (en) 2020-11-12
JP2021519587A (ja) 2021-08-12
CN112105731B (zh) 2024-08-30
WO2019186274A2 (en) 2019-10-03
AU2019244479B2 (en) 2024-12-19
SG11202009697RA (en) 2020-10-29
CN112105731A (zh) 2020-12-18
US11649455B2 (en) 2023-05-16
CA3133899A1 (en) 2019-10-03
EP3775214A2 (en) 2021-02-17
US20210095278A1 (en) 2021-04-01
WO2019186274A3 (en) 2019-12-05
ZA202006505B (en) 2024-02-28

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