JP7566766B2 - 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体 - Google Patents

抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体 Download PDF

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Publication number
JP7566766B2
JP7566766B2 JP2021553382A JP2021553382A JP7566766B2 JP 7566766 B2 JP7566766 B2 JP 7566766B2 JP 2021553382 A JP2021553382 A JP 2021553382A JP 2021553382 A JP2021553382 A JP 2021553382A JP 7566766 B2 JP7566766 B2 JP 7566766B2
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antigen
seq
binding fragment
bispecific antibody
antibody
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JP2022523442A (ja
JPWO2020183245A5 (enExample
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ガネーシャン，ラージクマール
グレワル，イクバル，エス．
セプルベダ，マニュエル，アレハンドロ
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ヤンセン バイオテツク，インコーポレーテツド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021553382A 2019-03-11 2020-03-11 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体 Active JP7566766B2 (ja)

Priority Applications (1)

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JP2024135000A JP2024170426A (ja) 2019-03-11 2024-08-13 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962816464P 2019-03-11 2019-03-11
US62/816,464 2019-03-11
PCT/IB2020/000342 WO2020183245A2 (en) 2019-03-11 2020-03-11 ANTI-Vβ17/ANTI-CD123 BISPECIFIC ANTIBODIES

Related Child Applications (1)

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JP2024135000A Division JP2024170426A (ja) 2019-03-11 2024-08-13 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体

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JP2022523442A JP2022523442A (ja) 2022-04-22
JPWO2020183245A5 JPWO2020183245A5 (enExample) 2023-03-17
JP7566766B2 true JP7566766B2 (ja) 2024-10-15

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JP2021553382A Active JP7566766B2 (ja) 2019-03-11 2020-03-11 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体
JP2024135000A Pending JP2024170426A (ja) 2019-03-11 2024-08-13 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体

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US (2) US12264197B2 (enExample)
EP (1) EP3937977A2 (enExample)
JP (2) JP7566766B2 (enExample)
KR (1) KR20210138033A (enExample)
CN (2) CN119954959A (enExample)
AU (1) AU2020235475A1 (enExample)
BR (1) BR112021017801A2 (enExample)
CA (1) CA3132916A1 (enExample)
IL (1) IL286147A (enExample)
MA (1) MA55305A (enExample)
MX (1) MX2021010857A (enExample)
WO (1) WO2020183245A2 (enExample)

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JP2023509708A (ja) 2020-01-03 2023-03-09 マレンゴ・セラピューティクス，インコーポレーテッド 抗ｔｃｒ抗体分子およびその使用
WO2022035722A1 (en) * 2020-08-10 2022-02-17 Janssen Biotech, Inc. Materials and methods for producing bioengineered virus specific lymphocytes
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TWI815194B (zh) * 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
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WO2023152633A1 (en) * 2022-02-09 2023-08-17 Janssen Biotech, Inc. Methods and compositions comprising v beta 17 bispecific t cell engagers and bioengineered virus specific lymphocytes
CN121127496A (zh) * 2023-02-09 2025-12-12 杨森生物技术公司 抗Vβ17/抗CD123双特异性抗体

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CN119954959A (zh) 2025-05-09
WO2020183245A3 (en) 2020-12-03
MX2021010857A (es) 2021-12-15
AU2020235475A1 (en) 2021-09-30
JP2022523442A (ja) 2022-04-22
CN113874400B (zh) 2025-02-07
MA55305A (fr) 2022-01-19
CN113874400A (zh) 2021-12-31
IL286147A (en) 2021-10-31
KR20210138033A (ko) 2021-11-18
WO2020183245A2 (en) 2020-09-17
EP3937977A2 (en) 2022-01-19
CA3132916A1 (en) 2020-09-17
JP2024170426A (ja) 2024-12-10
US12264197B2 (en) 2025-04-01
US20250257132A1 (en) 2025-08-14
US20220127359A1 (en) 2022-04-28
BR112021017801A2 (pt) 2022-01-18

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