JP7562691B2 - 微粒子捕捉デバイス - Google Patents

微粒子捕捉デバイス Download PDF

Info

Publication number
JP7562691B2
JP7562691B2 JP2022553719A JP2022553719A JP7562691B2 JP 7562691 B2 JP7562691 B2 JP 7562691B2 JP 2022553719 A JP2022553719 A JP 2022553719A JP 2022553719 A JP2022553719 A JP 2022553719A JP 7562691 B2 JP7562691 B2 JP 7562691B2
Authority
JP
Japan
Prior art keywords
layer
particle
captured
capture
containing liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022553719A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022070776A5 (https=
JPWO2022070776A1 (https=
Inventor
隆幸 小森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nok Corp
Original Assignee
Nok Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nok Corp filed Critical Nok Corp
Publication of JPWO2022070776A1 publication Critical patent/JPWO2022070776A1/ja
Publication of JPWO2022070776A5 publication Critical patent/JPWO2022070776A5/ja
Application granted granted Critical
Publication of JP7562691B2 publication Critical patent/JP7562691B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2022553719A 2020-09-29 2021-09-03 微粒子捕捉デバイス Active JP7562691B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020163376 2020-09-29
JP2020163376 2020-09-29
PCT/JP2021/032514 WO2022070776A1 (ja) 2020-09-29 2021-09-03 微粒子捕捉デバイス

Publications (3)

Publication Number Publication Date
JPWO2022070776A1 JPWO2022070776A1 (https=) 2022-04-07
JPWO2022070776A5 JPWO2022070776A5 (https=) 2023-06-07
JP7562691B2 true JP7562691B2 (ja) 2024-10-07

Family

ID=80950365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022553719A Active JP7562691B2 (ja) 2020-09-29 2021-09-03 微粒子捕捉デバイス

Country Status (5)

Country Link
US (1) US20230364612A1 (https=)
EP (1) EP4223865A4 (https=)
JP (1) JP7562691B2 (https=)
CN (1) CN116324367A (https=)
WO (1) WO2022070776A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035498A2 (en) 2005-09-15 2007-03-29 Artemis Health, Inc. Devices and methods for magnetic enrichment of cells and other particles
WO2013049860A1 (en) 2011-09-30 2013-04-04 Massachusetts Institute Of Technology Cell sorting by 3d flow and adhesive rolling
WO2014145075A2 (en) 2013-03-15 2014-09-18 The Trustees Of Princeton University Methods and devices for high throughpout purification
WO2015095395A1 (en) 2013-12-17 2015-06-25 The General Hospital Corporation Microfluidic devices for isolating particles
WO2019069900A1 (ja) 2017-10-03 2019-04-11 Nok株式会社 細胞捕捉装置
CN110468042A (zh) 2019-08-27 2019-11-19 无锡物联网创新中心有限公司 Ctc细胞分离微流控制装置和分离方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011078115A1 (ja) * 2009-12-25 2011-06-30 学校法人常翔学園 固液分離機能を有する装置、μ－ＴＡＳデバイス及び固液分離方法
JP5804620B2 (ja) 2010-08-09 2015-11-04 一般財団法人生産技術研究奨励会 電気的機能を持つマイクロチャンバーアレイ装置およびそれを用いた検査対象物解析方法
AU2014352822B2 (en) * 2013-11-22 2019-06-20 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
JP6611223B2 (ja) * 2015-03-13 2019-11-27 国立大学法人名古屋大学 微粒子分離用チップ、該微粒子分離用チップを用いた微粒子分離用システム、該部粒子分離用システムを用いた微粒子分離方法及び微粒子抽出方法
JP7006600B2 (ja) * 2016-08-23 2022-02-10 ソニーグループ株式会社 単一粒子捕捉用装置、単一粒子捕捉システム及び単一粒子の捕捉方法
FR3094242B1 (fr) 2019-03-28 2021-04-23 Exel Ind Canne et ensemble d’aspiration de peinture liquide et procédé de fabrication d’une telle canne
WO2022070841A1 (ja) * 2020-09-29 2022-04-07 Nok株式会社 白血球捕捉デバイス
JP7729536B2 (ja) * 2022-03-28 2025-08-26 国立大学法人茨城大学 白血球捕捉デバイス

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035498A2 (en) 2005-09-15 2007-03-29 Artemis Health, Inc. Devices and methods for magnetic enrichment of cells and other particles
WO2013049860A1 (en) 2011-09-30 2013-04-04 Massachusetts Institute Of Technology Cell sorting by 3d flow and adhesive rolling
WO2014145075A2 (en) 2013-03-15 2014-09-18 The Trustees Of Princeton University Methods and devices for high throughpout purification
WO2015095395A1 (en) 2013-12-17 2015-06-25 The General Hospital Corporation Microfluidic devices for isolating particles
WO2019069900A1 (ja) 2017-10-03 2019-04-11 Nok株式会社 細胞捕捉装置
CN110468042A (zh) 2019-08-27 2019-11-19 无锡物联网创新中心有限公司 Ctc细胞分离微流控制装置和分离方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biomicrofluidics，Vol.7, 014112，2013年02月27日，pp.1-16

Also Published As

Publication number Publication date
EP4223865A1 (en) 2023-08-09
CN116324367A (zh) 2023-06-23
WO2022070776A1 (ja) 2022-04-07
JPWO2022070776A1 (https=) 2022-04-07
US20230364612A1 (en) 2023-11-16
EP4223865A4 (en) 2024-11-13

Similar Documents

Publication Publication Date Title
US11052392B2 (en) Microfluidic device for cell separation and uses thereof
JP6752338B2 (ja) 粒子クラスタを単離するためのマイクロ流体方法およびシステム
CN105518464B (zh) 微流体分析的方法、组合物和系统
US9157839B2 (en) Separation and concentration of biological cells and biological particles using a one-dimensional channel
JP6744302B2 (ja) ミクロ流体装置における粒子の分類
CN104968417B (zh) 颗粒和细胞的高效率分离和操作
US8841135B2 (en) Biochip for high-throughput screening of circulating tumor cells
CN110257218B (zh) 利用影像操控电场力以筛选生物粒子的装置及其操作方法
Laxmi et al. Extracting white blood cells from blood on microfluidics platform: a review of isolation techniques and working mechanisms
JP7455339B2 (ja) 白血球捕捉デバイス
JP7562691B2 (ja) 微粒子捕捉デバイス
KR102263754B1 (ko) 비 뉴턴 유체와 미세 유체 채널을 이용한 바이오 샘플 분류방법 및 이를 이용한 미세 유체 칩
JP7104988B2 (ja) 粒子捕捉装置及び粒子捕捉方法
JP7729536B2 (ja) 白血球捕捉デバイス
TW202045243A (zh) 微流道裝置
Bayareh et al. Cancer cell separation using passive mechanisms: A review
Mane et al. Microfluidic systems for isolation of white blood cells: from design to practical applications

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A5211

Effective date: 20230210

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240222

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240702

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20240710

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240910

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240925

R150 Certificate of patent or registration of utility model

Ref document number: 7562691

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150