JP7553440B2 - 抗ｃｄ３３免疫細胞癌療法 - Google Patents

抗ｃｄ３３免疫細胞癌療法 Download PDF

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JP7553440B2
JP7553440B2 JP2021523715A JP2021523715A JP7553440B2 JP 7553440 B2 JP7553440 B2 JP 7553440B2 JP 2021523715 A JP2021523715 A JP 2021523715A JP 2021523715 A JP2021523715 A JP 2021523715A JP 7553440 B2 JP7553440 B2 JP 7553440B2
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JP2022512882A (ja
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アレクサンダー テレット ジョナサン
サガート ジェイソン
カライツィディス デメトリオス
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クリスパー セラピューティクス アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70521—CD28, CD152
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/0602—Vertebrate cells
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

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JP2021523715A 2018-11-07 2019-11-07 抗ｃｄ３３免疫細胞癌療法 Active JP7553440B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862756718P 2018-11-07 2018-11-07
US62/756,718 2018-11-07
US201862767388P 2018-11-14 2018-11-14
US201862767395P 2018-11-14 2018-11-14
US62/767,388 2018-11-14
US62/767,395 2018-11-14
US201962826643P 2019-03-29 2019-03-29
US201962826648P 2019-03-29 2019-03-29
US62/826,648 2019-03-29
US62/826,643 2019-03-29
PCT/IB2019/001194 WO2020095107A1 (en) 2018-11-07 2019-11-07 Anti-cd33 immune cell cancer therapy

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JP2022512882A JP2022512882A (ja) 2022-02-07
JP2022512882A5 JP2022512882A5 (https=) 2022-11-15
JP7553440B2 true JP7553440B2 (ja) 2024-09-18

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US (1) US20220226375A1 (https=)
EP (1) EP3877414A1 (https=)
JP (1) JP7553440B2 (https=)
KR (1) KR20210089712A (https=)
CN (1) CN113227141A (https=)
AU (1) AU2019377892A1 (https=)
BR (1) BR112021008041A2 (https=)
CA (1) CA3118816A1 (https=)
IL (1) IL282286A (https=)
MX (1) MX2021005398A (https=)
SG (1) SG11202103832SA (https=)
WO (1) WO2020095107A1 (https=)

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