JP7547215B2 - テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 - Google Patents
テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 Download PDFInfo
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- JP7547215B2 JP7547215B2 JP2020566737A JP2020566737A JP7547215B2 JP 7547215 B2 JP7547215 B2 JP 7547215B2 JP 2020566737 A JP2020566737 A JP 2020566737A JP 2020566737 A JP2020566737 A JP 2020566737A JP 7547215 B2 JP7547215 B2 JP 7547215B2
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024146283A JP7855033B2 (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| US201862677926P | 2018-05-30 | 2018-05-30 | |
| US62/677,926 | 2018-05-30 | ||
| US201862771397P | 2018-11-26 | 2018-11-26 | |
| US62/771,397 | 2018-11-26 | ||
| US201962822365P | 2019-03-22 | 2019-03-22 | |
| US62/822,365 | 2019-03-22 | ||
| GC2019-37662 | 2019-05-28 | ||
| GC201937662 | 2019-05-28 | ||
| PCT/US2019/034515 WO2019232126A1 (en) | 2018-05-30 | 2019-05-30 | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2024146283A Division JP7855033B2 (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| JP2021525746A JP2021525746A (ja) | 2021-09-27 |
| JP2021525746A5 JP2021525746A5 (enExample) | 2022-06-03 |
| JP7547215B2 true JP7547215B2 (ja) | 2024-09-09 |
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| JP2020566737A Active JP7547215B2 (ja) | 2018-05-30 | 2019-05-30 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| Country | Link |
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| US (2) | US12257252B2 (enExample) |
| EP (1) | EP3801534B1 (enExample) |
| JP (1) | JP7547215B2 (enExample) |
| CN (1) | CN112654356A (enExample) |
| BR (1) | BR112020024329A2 (enExample) |
| CA (1) | CA3102105A1 (enExample) |
| DK (1) | DK3801534T3 (enExample) |
| FI (1) | FI3801534T3 (enExample) |
| MX (1) | MX2020012980A (enExample) |
| WO (1) | WO2019232126A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA46973A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Polymorphes de sépiaptérine et leurs sels |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| FI3801536T3 (fi) * | 2018-05-30 | 2024-08-29 | Ptc Therapeutics Mp Inc | Sepiapteriinin antaminen ilman ruokaa käytettäväksi menetelmässä sepiapteriinin plasma-altistuksen lisäämiseksi |
| EP3801534B1 (en) | 2018-05-30 | 2026-02-18 | PTC Therapeutics MP, Inc. | Treatment of phenylketonuria with sepiapterin |
| EP4093405A1 (en) * | 2020-01-24 | 2022-11-30 | PTC Therapeutics MP, Inc. | Methods for treating parkinson's disease with sepiapterin |
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| JP2010523708A (ja) | 2007-04-11 | 2010-07-15 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| US20130108694A1 (en) | 2011-11-02 | 2013-05-02 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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| US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| JP2002515965A (ja) | 1995-08-18 | 2002-05-28 | ダブリュー． ランドリ，ドナルド | 抗体触媒反応の調節による有機化合物の検出 |
| US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
| US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2859996B1 (fr) | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| WO2005048926A2 (en) | 2003-11-13 | 2005-06-02 | The General Hospital Corporation | Methods for treating pain |
| PL1708690T3 (pl) | 2003-11-17 | 2017-01-31 | Biomarin Pharmaceutical Inc. | Leczenie fenyloketonurii za pomocą BH4 |
| JP5184783B2 (ja) | 2003-11-17 | 2013-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 |
| EP1687308B1 (en) | 2003-11-17 | 2019-06-12 | Merck & Cie | Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms |
| KR20070084270A (ko) | 2004-11-17 | 2007-08-24 | 바이오마린 파머수티컬 인크. | 안정한 정제 제형물 |
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| EP3213062B1 (en) | 2014-10-31 | 2020-02-12 | Children's Medical Center Corporation | Methods and assays relating to sepiapterin reductase inhibition |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| MA46973A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Polymorphes de sépiaptérine et leurs sels |
| JP7811085B2 (ja) * | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| EP3801534B1 (en) | 2018-05-30 | 2026-02-18 | PTC Therapeutics MP, Inc. | Treatment of phenylketonuria with sepiapterin |
| FI3801536T3 (fi) | 2018-05-30 | 2024-08-29 | Ptc Therapeutics Mp Inc | Sepiapteriinin antaminen ilman ruokaa käytettäväksi menetelmässä sepiapteriinin plasma-altistuksen lisäämiseksi |
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-
2019
- 2019-05-30 EP EP19810058.8A patent/EP3801534B1/en active Active
- 2019-05-30 WO PCT/US2019/034515 patent/WO2019232126A1/en not_active Ceased
- 2019-05-30 CA CA3102105A patent/CA3102105A1/en active Pending
- 2019-05-30 FI FIEP19810058.8T patent/FI3801534T3/fi active
- 2019-05-30 DK DK19810058.8T patent/DK3801534T3/da active
- 2019-05-30 BR BR112020024329-9A patent/BR112020024329A2/pt unknown
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- 2019-05-30 JP JP2020566737A patent/JP7547215B2/ja active Active
- 2019-05-30 CN CN201980050730.3A patent/CN112654356A/zh active Pending
- 2019-05-30 MX MX2020012980A patent/MX2020012980A/es unknown
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2025
- 2025-03-04 US US19/070,026 patent/US20250195529A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010523708A (ja) | 2007-04-11 | 2010-07-15 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| US20130108694A1 (en) | 2011-11-02 | 2013-05-02 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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| Title |
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| 医薬品の臨床薬物動態試験について，医薬審発第七九六号，各都道府県衛生主管部（局）長あて厚生労働省医薬局審査管理課長通知，2001年06月01日 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019232126A1 (en) | 2019-12-05 |
| US12257252B2 (en) | 2025-03-25 |
| EP3801534B1 (en) | 2026-02-18 |
| FI3801534T3 (fi) | 2026-04-14 |
| EP3801534A4 (en) | 2022-03-16 |
| EP3801534A1 (en) | 2021-04-14 |
| JP2024178188A (ja) | 2024-12-24 |
| US20250195529A1 (en) | 2025-06-19 |
| DK3801534T3 (da) | 2026-03-30 |
| US20210161901A1 (en) | 2021-06-03 |
| MX2020012980A (es) | 2021-04-29 |
| CA3102105A1 (en) | 2019-12-05 |
| CN112654356A (zh) | 2021-04-13 |
| BR112020024329A2 (pt) | 2021-02-23 |
| JP2021525746A (ja) | 2021-09-27 |
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