JP7528212B2 - 神経保護のための方法および組成物 - Google Patents

神経保護のための方法および組成物 Download PDF

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JP7528212B2
JP7528212B2 JP2022530807A JP2022530807A JP7528212B2 JP 7528212 B2 JP7528212 B2 JP 7528212B2 JP 2022530807 A JP2022530807 A JP 2022530807A JP 2022530807 A JP2022530807 A JP 2022530807A JP 7528212 B2 JP7528212 B2 JP 7528212B2
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disease
disorder
injury
antisense oligonucleotide
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JP2023503994A (ja
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レベンタール，リザ
エングバー，トーマス
エドゥアルド クラウス，ラウル
デブラジ，ラジェシュ
オーウェン ヒューズ，ロバート
ボサナック，トッド
アグラワル，スディール
エイ パッシーニ，マルコ
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02006—NAD(P)+ nucleosidase (3.2.2.6)
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    • C12N2310/30—Chemical structure
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    • C12N2310/53—Physical structure partially self-complementary or closed
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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2022530807A 2019-11-26 2020-11-25 神経保護のための方法および組成物 Active JP7528212B2 (ja)

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US201962940437P 2019-11-26 2019-11-26
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EP (1) EP4065714A1 (https=)
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KR (1) KR20220119366A (https=)
CN (1) CN115176002A (https=)
AU (1) AU2020391206A1 (https=)
BR (1) BR112022009772A2 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024112834A (ja) * 2019-11-26 2024-08-21 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物

Families Citing this family (6)

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PE20242222A1 (es) * 2022-03-14 2024-11-19 Lilly Co Eli Agentes de interferencia de arn de sarm1
CN116059367B (zh) * 2022-07-15 2025-02-18 浙江乘时佳生物科技有限公司 一种治疗阿尔茨海默症的sarm1抑制剂
JP2025523905A (ja) * 2022-07-21 2025-07-25 アミリックス ファーマシューティカルズ，インコーポレイティッド オリゴヌクレオチド組成物及びその方法
TW202547525A (zh) 2024-02-02 2025-12-16 美商美國禮來大藥廠 SARM1 RNAi藥劑
GB202408068D0 (en) 2024-06-06 2024-07-24 Univ London Treatment of cancer of the central nervous system
WO2025261431A1 (zh) * 2024-06-19 2025-12-26 上海拓界生物医药科技有限公司 靶向SARM1的RNAi剂及其医药用途

Citations (7)

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US20140079712A1 (en) 2011-06-24 2014-03-20 University Of Miami Therapeutic Applications Targeting SARM1
WO2017164230A1 (ja) 2016-03-23 2017-09-28 国立大学法人 岡山大学 リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用
WO2018057989A1 (en) 2016-09-24 2018-03-29 Washington University INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF
WO2019079572A1 (en) 2017-10-18 2019-04-25 Washington University NEGATIVE DOMINANT SARM1 MOLECULES AS A THERAPEUTIC STRATEGY FOR NEURODEGENERATIVE DISEASES OR DISORDERS
WO2019236879A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
WO2019236890A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
WO2019236884A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1

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Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140079712A1 (en) 2011-06-24 2014-03-20 University Of Miami Therapeutic Applications Targeting SARM1
WO2017164230A1 (ja) 2016-03-23 2017-09-28 国立大学法人 岡山大学 リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用
WO2018057989A1 (en) 2016-09-24 2018-03-29 Washington University INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF
WO2019079572A1 (en) 2017-10-18 2019-04-25 Washington University NEGATIVE DOMINANT SARM1 MOLECULES AS A THERAPEUTIC STRATEGY FOR NEURODEGENERATIVE DISEASES OR DISORDERS
WO2019236879A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
WO2019236890A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
WO2019236884A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024112834A (ja) * 2019-11-26 2024-08-21 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物
JP7796797B2 (ja) 2019-11-26 2026-01-09 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物

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KR20220119366A (ko) 2022-08-29
JP2024112834A (ja) 2024-08-21
MX2022006146A (es) 2022-10-18
US20230242909A1 (en) 2023-08-03
US12595481B2 (en) 2026-04-07
TW202134436A (zh) 2021-09-16
JP7796797B2 (ja) 2026-01-09
JP2023503994A (ja) 2023-02-01
WO2021108602A1 (en) 2021-06-03
IL293123A (en) 2022-07-01
AU2020391206A1 (en) 2022-05-19
CA3159374A1 (en) 2021-06-03
CN115176002A (zh) 2022-10-11
BR112022009772A2 (pt) 2022-08-16
EP4065714A1 (en) 2022-10-05

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