MX2022006146A - Metodos y composiciones para la neuroproteccion. - Google Patents

Metodos y composiciones para la neuroproteccion.

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Publication number
MX2022006146A
MX2022006146A MX2022006146A MX2022006146A MX2022006146A MX 2022006146 A MX2022006146 A MX 2022006146A MX 2022006146 A MX2022006146 A MX 2022006146A MX 2022006146 A MX2022006146 A MX 2022006146A MX 2022006146 A MX2022006146 A MX 2022006146A
Authority
MX
Mexico
Prior art keywords
compositions
methods
neuroprotection
diseases associated
neurodegenerative diseases
Prior art date
Application number
MX2022006146A
Other languages
English (en)
Inventor
Todd Bosanac
Thomas Engber
Marco A Passini
Sudhir Agrawal
Rajesh Devraj
Liza Leventhal
Raul Eduardo Krauss
Robert Owen Hughes
Original Assignee
Disarm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disarm Therapeutics Inc filed Critical Disarm Therapeutics Inc
Publication of MX2022006146A publication Critical patent/MX2022006146A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
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Abstract

La presente invención se refiere a composiciones y métodos para tratar la neurodegeneración y las enfermedades neurodegenerativas asociadas con la degeneración axonal. La neurodegeneración y las enfermedades neurodegenerativas asociadas con la degeneración axonal se tratan con terapias que comprenden inhibidores de SARM1 tales como oligonucleótidos antisentido de SARM1.
MX2022006146A 2019-11-26 2020-11-25 Metodos y composiciones para la neuroproteccion. MX2022006146A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962940437P 2019-11-26 2019-11-26
PCT/US2020/062289 WO2021108602A1 (en) 2019-11-26 2020-11-25 Methods and compositions for neuroprotection

Publications (1)

Publication Number Publication Date
MX2022006146A true MX2022006146A (es) 2022-10-18

Family

ID=74046136

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022006146A MX2022006146A (es) 2019-11-26 2020-11-25 Metodos y composiciones para la neuroproteccion.

Country Status (12)

Country Link
US (1) US20230242909A1 (es)
EP (1) EP4065714A1 (es)
JP (2) JP7528212B2 (es)
KR (1) KR20220119366A (es)
CN (1) CN115176002A (es)
AU (1) AU2020391206A1 (es)
BR (1) BR112022009772A2 (es)
CA (1) CA3159374A1 (es)
IL (1) IL293123A (es)
MX (1) MX2022006146A (es)
TW (1) TW202134436A (es)
WO (1) WO2021108602A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023177972A1 (en) 2022-03-14 2023-09-21 Eli Lilly And Company Sarm1 rna interference agents
TW202412817A (zh) * 2022-07-21 2024-04-01 美商艾米利克斯製藥公司 寡核苷酸組合物及其方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040096830A1 (en) * 2002-11-16 2004-05-20 Isis Pharmaceuticals Inc. Modulation of protein kinase D2 expression
WO2012178022A2 (en) 2011-06-24 2012-12-27 University Of Massachusetts Therapeutic applications targeting sarm1
US10968426B2 (en) * 2015-05-08 2021-04-06 President And Fellows Of Harvard College Universal donor stem cells and related methods
WO2017164230A1 (ja) 2016-03-23 2017-09-28 国立大学法人 岡山大学 リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用
JP7548696B2 (ja) * 2016-07-06 2024-09-10 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
CN110545804A (zh) 2016-09-24 2019-12-06 华盛顿大学 Sarm1 nad酶活性抑制剂及其用途
US20190365929A1 (en) * 2017-02-22 2019-12-05 Crispr Therapeutics Ag Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
AU2018351053A1 (en) 2017-10-18 2020-05-07 Washington University Dominant negative sarm1 molecules as a therapeutic strategy for neurodegenerative diseases or disorders
JP7478142B2 (ja) 2018-06-07 2024-05-02 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
MA52812A (fr) 2018-06-07 2021-04-14 Disarm Therapeutics Inc Inhibiteurs de sarm1
JP2021527125A (ja) 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドＤｉｓａｒｍ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｓａｒｍ１阻害剤

Also Published As

Publication number Publication date
BR112022009772A2 (pt) 2022-08-16
US20230242909A1 (en) 2023-08-03
AU2020391206A1 (en) 2022-05-19
WO2021108602A1 (en) 2021-06-03
EP4065714A1 (en) 2022-10-05
IL293123A (en) 2022-07-01
TW202134436A (zh) 2021-09-16
JP2023503994A (ja) 2023-02-01
CN115176002A (zh) 2022-10-11
JP2024112834A (ja) 2024-08-21
KR20220119366A (ko) 2022-08-29
CA3159374A1 (en) 2021-06-03
JP7528212B2 (ja) 2024-08-05

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