JP7527977B2 - 眼疾患の治療における使用のための、フォトクロミック化合物 - Google Patents

眼疾患の治療における使用のための、フォトクロミック化合物 Download PDF

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JP7527977B2
JP7527977B2 JP2020567613A JP2020567613A JP7527977B2 JP 7527977 B2 JP7527977 B2 JP 7527977B2 JP 2020567613 A JP2020567613 A JP 2020567613A JP 2020567613 A JP2020567613 A JP 2020567613A JP 7527977 B2 JP7527977 B2 JP 7527977B2
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compounds
diapin
dmso
membrane
light
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JP2021525776A (ja
JP2021525776A5 (enExample
Inventor
グリエルモ・ランツァーニ
ジュゼッペ・マリア・パテルノ
フランチェスコ・ロドーラ
キアーラ・ベルタレッリ
ファビオ・ベンフェナーティ
マッティア・ロレンツォ・ディフランチェスコ
エリザベッタ・コロンボ
ホセ・フェルナンド・マヤ－ベテンコウルト
レティツィア・コレッラ
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Fondazione Istituto Italiano di Tecnologia
Politecnico di Milano
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Fondazione Istituto Italiano di Tecnologia
Politecnico di Milano
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
JP2020567613A 2018-06-04 2019-05-31 眼疾患の治療における使用のための、フォトクロミック化合物 Active JP7527977B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102018000005987 2018-06-04
IT102018000005987A IT201800005987A1 (it) 2018-06-04 2018-06-04 Composti fotocromici
PCT/IB2019/054530 WO2019234567A1 (en) 2018-06-04 2019-05-31 Photochromic compounds for use in the treatment of eye disorders

Publications (3)

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JP2021525776A JP2021525776A (ja) 2021-09-27
JP2021525776A5 JP2021525776A5 (enExample) 2022-06-03
JP7527977B2 true JP7527977B2 (ja) 2024-08-05

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JP2020567613A Active JP7527977B2 (ja) 2018-06-04 2019-05-31 眼疾患の治療における使用のための、フォトクロミック化合物

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Country Link
US (1) US11401250B2 (enExample)
EP (1) EP3802491B1 (enExample)
JP (1) JP7527977B2 (enExample)
IT (1) IT201800005987A1 (enExample)
WO (1) WO2019234567A1 (enExample)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110207213A1 (en) 2008-10-31 2011-08-25 Dirk Trauner Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof
CN104230746A (zh) 2014-08-14 2014-12-24 毕宏生 一种化学光转化物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490460A (de) * 1966-05-27 1970-05-15 Ciba Geigy Verfahren zur Herstellung neuer basischer Azofarbstoffe
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
JP4161583B2 (ja) * 2002-02-07 2008-10-08 コニカミノルタホールディングス株式会社 偏光板の製造方法
EP2214660A2 (en) * 2007-10-12 2010-08-11 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110207213A1 (en) 2008-10-31 2011-08-25 Dirk Trauner Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof
CN104230746A (zh) 2014-08-14 2014-12-24 毕宏生 一种化学光转化物及其制备方法和用途

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRITISH JOURNAL OF PHARMACOLOGY，2017年，Vol. 175，pp. 2296-2311
Chemistry Letters，1980年，No. 4，pp. 421-424
Dyes and Pigments，1993年，Vol. 23, No. 3，pp. 149-157
JOURNAL FUER PRAKTISCHE CHEMIE，1998年，Vol. 340, No. 2，pp. 122-128
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY，2012年，Vol. 134, No. 10，pp. 4898-4904
MACROMOLECULES，2009年，Vol. 42, No. 13，pp. 4775-4786

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Publication number Publication date
WO2019234567A1 (en) 2019-12-12
US20210238156A1 (en) 2021-08-05
JP2021525776A (ja) 2021-09-27
EP3802491B1 (en) 2024-03-20
US11401250B2 (en) 2022-08-02
WO2019234567A9 (en) 2020-12-30
EP3802491A1 (en) 2021-04-14
IT201800005987A1 (it) 2019-12-04
EP3802491C0 (en) 2024-03-20

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