IT201800005987A1 - Composti fotocromici - Google Patents

Composti fotocromici Download PDF

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Publication number
IT201800005987A1
IT201800005987A1 IT102018000005987A IT201800005987A IT201800005987A1 IT 201800005987 A1 IT201800005987 A1 IT 201800005987A1 IT 102018000005987 A IT102018000005987 A IT 102018000005987A IT 201800005987 A IT201800005987 A IT 201800005987A IT 201800005987 A1 IT201800005987 A1 IT 201800005987A1
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IT
Italy
Prior art keywords
compounds
compounds according
ziapin
dmso
independently
Prior art date
Application number
IT102018000005987A
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English (en)
Italian (it)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to IT102018000005987A priority Critical patent/IT201800005987A1/it
Priority to EP19733876.7A priority patent/EP3802491B1/en
Priority to PCT/IB2019/054530 priority patent/WO2019234567A1/en
Priority to US16/972,336 priority patent/US11401250B2/en
Priority to JP2020567613A priority patent/JP7527977B2/ja
Publication of IT201800005987A1 publication Critical patent/IT201800005987A1/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
IT102018000005987A 2018-06-04 2018-06-04 Composti fotocromici IT201800005987A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT102018000005987A IT201800005987A1 (it) 2018-06-04 2018-06-04 Composti fotocromici
EP19733876.7A EP3802491B1 (en) 2018-06-04 2019-05-31 Photochromic compounds for use in the treatment of eye disorders
PCT/IB2019/054530 WO2019234567A1 (en) 2018-06-04 2019-05-31 Photochromic compounds for use in the treatment of eye disorders
US16/972,336 US11401250B2 (en) 2018-06-04 2019-05-31 Photochromic compounds for use in the treatment of eye disorders
JP2020567613A JP7527977B2 (ja) 2018-06-04 2019-05-31 眼疾患の治療における使用のための、フォトクロミック化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102018000005987A IT201800005987A1 (it) 2018-06-04 2018-06-04 Composti fotocromici

Publications (1)

Publication Number Publication Date
IT201800005987A1 true IT201800005987A1 (it) 2019-12-04

Family

ID=63312371

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102018000005987A IT201800005987A1 (it) 2018-06-04 2018-06-04 Composti fotocromici

Country Status (5)

Country Link
US (1) US11401250B2 (enExample)
EP (1) EP3802491B1 (enExample)
JP (1) JP7527977B2 (enExample)
IT (1) IT201800005987A1 (enExample)
WO (1) WO2019234567A1 (enExample)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538074A (en) * 1966-05-27 1970-11-03 Ciba Ltd Basic mono azo dyestuffs
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
JP2003232919A (ja) * 2002-02-07 2003-08-22 Konica Corp 偏光板及びその製造方法、並びに光学要素
WO2009051670A2 (en) * 2007-10-12 2009-04-23 Resolvyx Pharmaceuticals, Inc. Oxylipin compounds for the treatment of ophthalmic conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010051343A1 (en) 2008-10-31 2010-05-06 The Regents Of The University Of California Photoreactive synthetic regulator of protein function and methods of use thereof
CN104230746B (zh) 2014-08-14 2015-12-02 毕宏生 一种化学光转化物及其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538074A (en) * 1966-05-27 1970-11-03 Ciba Ltd Basic mono azo dyestuffs
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
JP2003232919A (ja) * 2002-02-07 2003-08-22 Konica Corp 偏光板及びその製造方法、並びに光学要素
WO2009051670A2 (en) * 2007-10-12 2009-04-23 Resolvyx Pharmaceuticals, Inc. Oxylipin compounds for the treatment of ophthalmic conditions

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALEXANDRE MOUROT ET AL: "Themed Section: Recent Advances in Targeting Ion Channels to Treat Chronic Pain RESEARCH PAPER Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches BACKGROUND AND PURPOSE", BRITISH JOURNAL OF PHARMACOLOGY BRITISH JOURNAL OF PHARMACOLOGY, vol. 175, 27 July 2017 (2017-07-27), pages 2296 - 2311, XP055555781 *
ANTOINE DIGUET ET AL: "UV-Induced Bursting of Cell-Sized Multicomponent Lipid Vesicles in a Photosensitive Surfactant Solution", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 10, 28 February 2012 (2012-02-28), pages 4898 - 4904, XP055554783, ISSN: 0002-7863, DOI: 10.1021/ja211664f *
HASHIMOTO Y ED - NEIDLE STEPHEN: "Structural development of biological response modifiers based on thalidomide", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 10, no. 3, 1 January 2002 (2002-01-01), pages 461 - 479, XP002313794, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(01)00308-X *
JINLAN ZHOU ET AL: "Synthesis, thermal stability and photoresponsive behaviors of azobenzene-tethered polyhedral oligomeric silsesquioxanes", NEW JOURNAL OF CHEMISTRY, vol. 35, no. 12, 1 January 2011 (2011-01-01), GB, pages 2781, XP055555212, ISSN: 1144-0546, DOI: 10.1039/c1nj20577c *
M. KASPAR ET AL: "Thermal Properties of Liquid-Crystalline Diols and Corresponding Bis-Urethanes with Mesogenic Groups of Various Structures in Side Chains", MOLECULAR CRYSTALS AND LIQUID CRYSTALS, vol. 392, no. 1, 18 January 2003 (2003-01-18), UK, pages 17 - 30, XP055555220, ISSN: 1542-1406, DOI: 10.1080/15421400390193954 *
PENCHEV A ET AL: "PROPERTIES OF AZO DYES DERIVED FROM 2-(N-SUBSTITUTED ALKYL-N-ARYLAMINO)ETHYLTRIMETHYL-AMMONIUM SALTS. \PART I: PHENYLAMINO DERIVATIVES", DYES AND PIGMENTS, ELSEVIER APPLIED SCIENCE PUBLISHERS. BARKING, GB, vol. 18, no. 3, 1 January 1992 (1992-01-01), pages 227 - 235, XP000245994, ISSN: 0143-7208, DOI: 10.1016/0143-7208(92)87005-L *
QIAN ZHANG ET AL: "Liquid Crystallinity and Other Properties in Complexes of Cationic Azo-Containing Surfactomesogens with Poly(styrenesulfonate)", MACROMOLECULES, vol. 42, no. 13, 14 July 2009 (2009-07-14), US, pages 4775 - 4786, XP055555412, ISSN: 0024-9297, DOI: 10.1021/ma9002566 *
RUIQING XIAO ET AL: "A Photo-responsive Catalytic Vesicle with GPx Activity", CHINESE JOURNAL OF CHEMISTRY, vol. 32, no. 1, 11 December 2013 (2013-12-11), CN, pages 37 - 43, XP055554712, ISSN: 1001-604X, DOI: 10.1002/cjoc.201300695 *
TIRELLI N ET AL: "STRUCTURE-ACTIVITY RELATIONSHIP OF NEW ORGANIC NLO MATERIALS BASED ON PUSH-PULL AZODYES. 1. SYNTHESIS AND MOLECULAR PROPERTIES OF THE DYES", JOURNAL FUER PRAKTISCHE CHEMIE, WILEY VCH, WEINHEIM, DE, vol. 340, no. 2, 1 January 1998 (1998-01-01), pages 122 - 128, XP000953593, ISSN: 1436-9966, DOI: 10.1002/PRAC.19983400204 *
VICTORIA PEDDIE ET AL: "Synthesis and Solution Aggregation Studies of a Suite of Mixed Neutral and Zwitterionic Chromophores for Second-Order Nonlinear Optics", JOURNAL OF ORGANIC CHEMISTRY, vol. 79, no. 21, 13 October 2014 (2014-10-13), pages 10153 - 10169, XP055555407, ISSN: 0022-3263, DOI: 10.1021/jo5018124 *

Also Published As

Publication number Publication date
JP7527977B2 (ja) 2024-08-05
WO2019234567A1 (en) 2019-12-12
US20210238156A1 (en) 2021-08-05
JP2021525776A (ja) 2021-09-27
EP3802491B1 (en) 2024-03-20
US11401250B2 (en) 2022-08-02
WO2019234567A9 (en) 2020-12-30
EP3802491A1 (en) 2021-04-14
EP3802491C0 (en) 2024-03-20

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