JP7514533B2 - アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 - Google Patents

アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 Download PDF

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JP7514533B2
JP7514533B2 JP2020542422A JP2020542422A JP7514533B2 JP 7514533 B2 JP7514533 B2 JP 7514533B2 JP 2020542422 A JP2020542422 A JP 2020542422A JP 2020542422 A JP2020542422 A JP 2020542422A JP 7514533 B2 JP7514533 B2 JP 7514533B2
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alpha
thf
polyglutamylated
tetrahydrofolate
αpthf
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JP2021513525A (ja
JP2021513525A5 (enExample
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ニイェキザ，クレト
モヨ，ヴィクター，マンドラ
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LEAF Holdings Group LLC
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LEAF Holdings Group LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/28—Compounds containing heavy metals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

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JP2020542422A 2018-02-07 2019-02-07 アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 Active JP7514533B2 (ja)

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JP2024101225A JP7674775B2 (ja) 2018-02-07 2024-06-24 アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用
JP2025069103A JP2025108646A (ja) 2018-02-07 2025-04-18 アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用

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US201862627741P 2018-02-07 2018-02-07
US62/627,741 2018-02-07
US201862630825P 2018-02-14 2018-02-14
US201862630820P 2018-02-14 2018-02-14
US62/630,820 2018-02-14
US62/630,825 2018-02-14
US201862636294P 2018-02-28 2018-02-28
US62/636,294 2018-02-28
US201862662374P 2018-04-25 2018-04-25
US62/662,374 2018-04-25
US201862702732P 2018-07-24 2018-07-24
US62/702,732 2018-07-24
US201862764943P 2018-08-17 2018-08-17
US62/764,943 2018-08-17
PCT/US2019/016955 WO2019157120A1 (en) 2018-02-07 2019-02-07 Alpha polyglutamated tetrahydrofolates and uses thereof

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