JP7485368B2 - 新規な融合タンパク質およびこれを含む癌の予防または治療用薬学的組成物 - Google Patents
新規な融合タンパク質およびこれを含む癌の予防または治療用薬学的組成物 Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2018-0048343 | 2018-04-26 | ||
| KR20180048343 | 2018-04-26 | ||
| PCT/KR2019/005096 WO2019209078A1 (ko) | 2018-04-26 | 2019-04-26 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
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| JP2021521817A JP2021521817A (ja) | 2021-08-30 |
| JP2021521817A5 JP2021521817A5 (enExample) | 2022-04-19 |
| JP7485368B2 true JP7485368B2 (ja) | 2024-05-16 |
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| EP (1) | EP3792276A4 (enExample) |
| JP (1) | JP7485368B2 (enExample) |
| KR (3) | KR102194644B1 (enExample) |
| CN (1) | CN112041333B (enExample) |
| WO (1) | WO2019209078A1 (enExample) |
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| AU2019309472A1 (en) * | 2018-07-24 | 2021-03-18 | Good T Cells, Inc. | Composition for preventing or treating immune-related diseases |
| EP3943107A4 (en) * | 2019-03-20 | 2022-12-07 | Good T Cells, Inc. | COMPOSITION FOR THE PREVENTION OR TREATMENT OF BRAIN AND NERVOUS SYSTEM DISEASES |
| CN114929733A (zh) * | 2019-11-08 | 2022-08-19 | 古德T细胞有限公司 | 调节性t细胞表面抗原的表位和与其特异性结合的抗体 |
| CN111285936A (zh) * | 2020-03-11 | 2020-06-16 | 北京双赢科创生物科技有限公司 | 靶向肿瘤的酸性敏感纳米肽段及其应用 |
| CN122161853A (zh) * | 2023-09-06 | 2026-06-05 | 古德T细胞有限公司 | 经亲和力成熟的新型抗体 |
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| JP2010513471A (ja) | 2006-12-21 | 2010-04-30 | モガム バイオテクノロジー リサーチ インスティチュート | 免疫グロブリンＦｃ及びヒトアポリポタンパク質クリングル断片の融合タンパク質 |
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| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| EP1699821B1 (en) * | 2003-12-31 | 2012-06-20 | Merck Patent GmbH | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| EP1907582B1 (en) * | 2005-07-27 | 2012-01-04 | Oncotherapy Science, Inc. | Ect2 as a therapeutic target for esophageal cancer |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| CN101687933B (zh) | 2007-05-30 | 2015-11-25 | 浦项工科大学校产学协力团 | 免疫球蛋白融合蛋白 |
| CA2695374A1 (en) * | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
| CN101891823B (zh) | 2010-06-11 | 2012-10-03 | 北京东方百泰生物科技有限公司 | 一种Exendin-4及其类似物融合蛋白 |
| KR101847523B1 (ko) | 2011-01-24 | 2018-05-28 | 연세대학교 산학협력단 | 조절자 Ｔ 세포에 특이적으로 존재하는 새로운 표면단백질 Ｌｒｉｇ-1의 용도 |
| US9156897B2 (en) | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| EP3456734B1 (en) | 2012-10-04 | 2022-01-05 | Research Development Foundation | Serine protease molecules and therapies |
| JP6404349B2 (ja) | 2013-07-30 | 2018-10-10 | インダストリー−アカデミック コーポレーション ファウンデーション，ヨンセイ ユニバーシティ | サクサチリン−Ｆｃ融合タンパク質及びその用途 |
| AU2019309472A1 (en) * | 2018-07-24 | 2021-03-18 | Good T Cells, Inc. | Composition for preventing or treating immune-related diseases |
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| JP2010513471A (ja) | 2006-12-21 | 2010-04-30 | モガム バイオテクノロジー リサーチ インスティチュート | 免疫グロブリンＦｃ及びヒトアポリポタンパク質クリングル断片の融合タンパク質 |
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| J. Mol. Biol.，2015年，vol.427，p.1934-1948 |
| Neuro-Oncology，2013年，vol.15, no.9，p.1200-1211 |
| Oncogene，2007年，vol.26，p.368-381 |
Also Published As
| Publication number | Publication date |
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| KR102194644B1 (ko) | 2020-12-24 |
| WO2019209078A1 (ko) | 2019-10-31 |
| KR20200144524A (ko) | 2020-12-29 |
| CN112041333A (zh) | 2020-12-04 |
| CN112041333B (zh) | 2024-06-28 |
| US11820801B2 (en) | 2023-11-21 |
| EP3792276A1 (en) | 2021-03-17 |
| KR20230146491A (ko) | 2023-10-19 |
| EP3792276A4 (en) | 2022-02-16 |
| JP2021521817A (ja) | 2021-08-30 |
| KR20190124665A (ko) | 2019-11-05 |
| US20210130422A1 (en) | 2021-05-06 |
| KR102754984B1 (ko) | 2025-01-21 |
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