JP7477457B2 - Ｃ３結合薬及びその使用方法 - Google Patents

Ｃ３結合薬及びその使用方法 Download PDF

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JP7477457B2
JP7477457B2 JP2020554097A JP2020554097A JP7477457B2 JP 7477457 B2 JP7477457 B2 JP 7477457B2 JP 2020554097 A JP2020554097 A JP 2020554097A JP 2020554097 A JP2020554097 A JP 2020554097A JP 7477457 B2 JP7477457 B2 JP 7477457B2
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seq
amino acid
acid sequence
set forth
sequence set
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JP2021520195A (ja
JP2021520195A5 (enExample
Inventor
ダナ イェン メイ デューイ，
ジョンハオ リウ，
ジエ タン，
ヤン ワン，
イユアン イン，
ウェンウー ジャイ，
ジャレッド マーティン ヒグビー，
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エヌジーエム バイオファーマシューティカルス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020554097A 2018-04-03 2019-04-01 Ｃ３結合薬及びその使用方法 Active JP7477457B2 (ja)

Priority Applications (1)

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JP2024019502A JP2024056851A (ja) 2018-04-03 2024-02-13 Ｃ３結合薬及びその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862652253P 2018-04-03 2018-04-03
US62/652,253 2018-04-03
PCT/US2019/025123 WO2019195136A1 (en) 2018-04-03 2019-04-01 C3-binding agents and methods of use thereof

Related Child Applications (1)

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JP2024019502A Division JP2024056851A (ja) 2018-04-03 2024-02-13 Ｃ３結合薬及びその使用方法

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JP2021520195A JP2021520195A (ja) 2021-08-19
JP2021520195A5 JP2021520195A5 (enExample) 2022-04-08
JP7477457B2 true JP7477457B2 (ja) 2024-05-01

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JP2024019502A Pending JP2024056851A (ja) 2018-04-03 2024-02-13 Ｃ３結合薬及びその使用方法

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US (3) US11136381B2 (enExample)
EP (1) EP3790897A1 (enExample)
JP (2) JP7477457B2 (enExample)
KR (1) KR20200138290A (enExample)
CN (1) CN112105638A (enExample)
AR (1) AR117565A1 (enExample)
AU (1) AU2019248557A1 (enExample)
BR (1) BR112020019907A2 (enExample)
CA (1) CA3093356A1 (enExample)
CL (2) CL2020002522A1 (enExample)
CO (1) CO2020013468A2 (enExample)
IL (1) IL277404A (enExample)
MX (1) MX2020010323A (enExample)
PE (1) PE20212132A1 (enExample)
PH (1) PH12020500664A1 (enExample)
SG (1) SG11202008897SA (enExample)
TW (1) TWI833742B (enExample)
WO (1) WO2019195136A1 (enExample)

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US11136381B2 (en) 2018-04-03 2021-10-05 Ngm Biopharmaceuticals, Inc. Anti-C3 antibodies
WO2021226442A2 (en) 2020-05-08 2021-11-11 Ngm Biopharmaceuticals, Inc. Therapeutic uses of c3-binding agents
EP4213808A4 (en) * 2020-09-21 2024-05-22 Apellis Pharmaceuticals, Inc. Methods of treating eye disorders
US20220259296A1 (en) * 2021-02-12 2022-08-18 Boehringer Ingelheim International Gmbh Complement c3 antigen binding proteins
PE20250390A1 (es) * 2021-12-22 2025-02-11 Boehringer Ingelheim Int Anticuerpos anti-c3 y fragmentos de union al antigeno de estos y sus usos para tratar enfermedades oftalmicas u oculares
WO2024086555A1 (en) * 2022-10-17 2024-04-25 Ngm Biopharmaceuticals, Inc. Uses of anti-c3 antibodies
CN117447601B (zh) * 2023-12-22 2024-03-08 北京索莱宝科技有限公司 猪IgM的抗体、抗体组合物及其应用
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031240A1 (en) 2002-10-04 2004-04-15 Stichting Sanquin Bloedvoorziening Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation
JP2012525829A (ja) 2009-05-06 2012-10-25 ノバルティス アーゲー 補体タンパク質Ｃ３ｂを標的とする抗体の組成物および方法
JP2015514112A (ja) 2012-04-03 2015-05-18 ノーベルメッド セラピューティクス インコーポレイテッド． ヒト化およびキメラ抗ｃ３因子抗体、ならびにその使用

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US7816497B2 (en) 2002-10-30 2010-10-19 University Of Kentucky Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration
EP1558645B1 (en) * 2002-11-08 2011-07-27 Ablynx N.V. Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
US20090004183A1 (en) 2004-07-23 2009-01-01 Taylor Ronald P Compositions and Methods for Regulating the Alternative Pathway of Complement
CA2593846A1 (en) 2005-01-14 2006-08-10 The Regents Of The University Of California Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
DK2500030T4 (en) 2005-11-04 2018-10-29 Genentech Inc Use of complement pathway inhibitors for the treatment of eye diseases
EP2148691B1 (en) 2007-02-05 2015-05-20 Apellis Pharmaceuticals, Inc. Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system
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AU2008262048B2 (en) 2007-06-07 2013-09-26 Genentech, Inc. C3b antibodies and methods for the prevention and treatment of complement- associated disorders
AU2010250452B2 (en) 2009-05-20 2014-06-05 Toray Industries, Inc. Cell membrane-permeable peptides
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US20130177567A1 (en) 2010-05-18 2013-07-11 Sydansk Universitet Novel c3c epitope, antibodies binding thereto, and use thereof
BR112012033119A2 (pt) 2010-06-22 2016-10-25 Univ Colorado Regents anticorpos para o fragamento c3d do componente do complemento 3.
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WO2004031240A1 (en) 2002-10-04 2004-04-15 Stichting Sanquin Bloedvoorziening Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation
JP2012525829A (ja) 2009-05-06 2012-10-25 ノバルティス アーゲー 補体タンパク質Ｃ３ｂを標的とする抗体の組成物および方法
JP2015514112A (ja) 2012-04-03 2015-05-18 ノーベルメッド セラピューティクス インコーポレイテッド． ヒト化およびキメラ抗ｃ３因子抗体、ならびにその使用

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Also Published As

Publication number Publication date
US11767359B2 (en) 2023-09-26
SG11202008897SA (en) 2020-10-29
JP2021520195A (ja) 2021-08-19
RU2020135712A (ru) 2022-05-04
US11136381B2 (en) 2021-10-05
AR117565A1 (es) 2021-08-18
JP2024056851A (ja) 2024-04-23
US20230382985A1 (en) 2023-11-30
CL2021002039A1 (es) 2022-04-01
MX2020010323A (es) 2021-01-08
CL2020002522A1 (es) 2021-02-26
US20190322730A1 (en) 2019-10-24
PH12020500664A1 (en) 2021-06-07
WO2019195136A1 (en) 2019-10-10
CO2020013468A2 (es) 2020-11-10
KR20200138290A (ko) 2020-12-09
IL277404A (en) 2020-11-30
TWI833742B (zh) 2024-03-01
US20220119508A1 (en) 2022-04-21
BR112020019907A2 (pt) 2021-01-05
AU2019248557A1 (en) 2020-09-24
TW202003559A (zh) 2020-01-16
EP3790897A1 (en) 2021-03-17
CN112105638A (zh) 2020-12-18
PE20212132A1 (es) 2021-11-05
CA3093356A1 (en) 2019-10-10

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