TWI833742B - Ｃ３結合劑及其使用方法 - Google Patents
Ｃ３結合劑及其使用方法 Download PDFInfo
- Publication number
- TWI833742B TWI833742B TW108111549A TW108111549A TWI833742B TW I833742 B TWI833742 B TW I833742B TW 108111549 A TW108111549 A TW 108111549A TW 108111549 A TW108111549 A TW 108111549A TW I833742 B TWI833742 B TW I833742B
- Authority
- TW
- Taiwan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence shown
- cdr2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652253P | 2018-04-03 | 2018-04-03 | |
| US62/652,253 | 2018-04-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202003559A TW202003559A (zh) | 2020-01-16 |
| TWI833742B true TWI833742B (zh) | 2024-03-01 |
Family
ID=66630340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108111549A TWI833742B (zh) | 2018-04-03 | 2019-04-01 | Ｃ３結合劑及其使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11136381B2 (enExample) |
| EP (1) | EP3790897A1 (enExample) |
| JP (2) | JP7477457B2 (enExample) |
| KR (1) | KR20200138290A (enExample) |
| CN (1) | CN112105638A (enExample) |
| AR (1) | AR117565A1 (enExample) |
| AU (1) | AU2019248557A1 (enExample) |
| BR (1) | BR112020019907A2 (enExample) |
| CA (1) | CA3093356A1 (enExample) |
| CL (2) | CL2020002522A1 (enExample) |
| CO (1) | CO2020013468A2 (enExample) |
| IL (1) | IL277404A (enExample) |
| MX (1) | MX2020010323A (enExample) |
| PE (1) | PE20212132A1 (enExample) |
| PH (1) | PH12020500664A1 (enExample) |
| SG (1) | SG11202008897SA (enExample) |
| TW (1) | TWI833742B (enExample) |
| WO (1) | WO2019195136A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7477457B2 (ja) | 2018-04-03 | 2024-05-01 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | Ｃ３結合薬及びその使用方法 |
| WO2021226442A2 (en) | 2020-05-08 | 2021-11-11 | Ngm Biopharmaceuticals, Inc. | Therapeutic uses of c3-binding agents |
| EP4213808A4 (en) * | 2020-09-21 | 2024-05-22 | Apellis Pharmaceuticals, Inc. | Methods of treating eye disorders |
| WO2022171771A1 (en) * | 2021-02-12 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Complement c3 antigen binding proteins |
| CR20240265A (es) | 2021-12-22 | 2024-10-16 | Boehringer Ingelheim Int | Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares |
| WO2024086555A1 (en) * | 2022-10-17 | 2024-04-25 | Ngm Biopharmaceuticals, Inc. | Uses of anti-c3 antibodies |
| CN117447601B (zh) * | 2023-12-22 | 2024-03-08 | 北京索莱宝科技有限公司 | 猪IgM的抗体、抗体组合物及其应用 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031240A1 (en) * | 2002-10-04 | 2004-04-15 | Stichting Sanquin Bloedvoorziening | Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation |
| WO2010136311A2 (en) * | 2009-05-06 | 2010-12-02 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01002580A (es) * | 1998-09-10 | 2002-04-08 | Univ Virginia | Anticuerpos para c3b(1) para el suministro de agentes de diagnostico y terapeuticos para celulas cancerosas. |
| US7816497B2 (en) | 2002-10-30 | 2010-10-19 | University Of Kentucky | Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration |
| EP1558645B1 (en) * | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| US20090004183A1 (en) | 2004-07-23 | 2009-01-01 | Taylor Ronald P | Compositions and Methods for Regulating the Alternative Pathway of Complement |
| CA2593846A1 (en) | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| SG10201804008UA (en) | 2005-11-04 | 2018-06-28 | Genentech Inc | Use of complement pathway inhibitors to treat ocular diseases |
| HUE026001T2 (en) | 2007-02-05 | 2016-04-28 | Apellis Pharmaceuticals Inc | Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system |
| US8192742B2 (en) | 2007-03-23 | 2012-06-05 | NovelMed Therapeutics | Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof |
| US9745367B2 (en) | 2007-03-23 | 2017-08-29 | Novelmed Theraputics, Inc. | Alternative pathway specific antibodies for treating arthritis |
| RU2473563C2 (ru) | 2007-06-07 | 2013-01-27 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ C3b И СПОСОБЫ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ СВЯЗАННЫХ С КОМПЛЕМЕНТОМ НАРУШЕНИЙ |
| RU2548807C2 (ru) | 2009-05-20 | 2015-04-20 | Торэй Индастриз, Инк. | Пептиды, проникающие в клетку |
| WO2010135717A2 (en) | 2009-05-21 | 2010-11-25 | Potentia Pharmaceuticals, Inc. | Complement assays and uses thereof |
| US20130177567A1 (en) | 2010-05-18 | 2013-07-11 | Sydansk Universitet | Novel c3c epitope, antibodies binding thereto, and use thereof |
| SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
| CA2869477C (en) * | 2012-04-03 | 2020-06-09 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor c3 antibodies and uses thereof |
| AU2014370404A1 (en) | 2013-12-24 | 2016-07-07 | Novelmed Therapeutics, Inc. | Compositions and methods of treating ocular diseases |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| CN116059378A (zh) * | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| WO2017048466A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Compositions and methods for delivering biotherapeutics |
| US11903994B2 (en) | 2015-10-07 | 2024-02-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| JP2020528082A (ja) | 2017-07-17 | 2020-09-17 | ロイズマン，キース | 加齢黄斑変性と他の眼疾患の治療用の細胞透過性ペプチドを使用する治療薬の局所送達 |
| JP7477457B2 (ja) | 2018-04-03 | 2024-05-01 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | Ｃ３結合薬及びその使用方法 |
-
2019
- 2019-04-01 JP JP2020554097A patent/JP7477457B2/ja active Active
- 2019-04-01 WO PCT/US2019/025123 patent/WO2019195136A1/en not_active Ceased
- 2019-04-01 KR KR1020207030405A patent/KR20200138290A/ko active Pending
- 2019-04-01 BR BR112020019907-9A patent/BR112020019907A2/pt unknown
- 2019-04-01 CN CN201980027315.6A patent/CN112105638A/zh active Pending
- 2019-04-01 EP EP19725880.9A patent/EP3790897A1/en not_active Withdrawn
- 2019-04-01 AU AU2019248557A patent/AU2019248557A1/en not_active Abandoned
- 2019-04-01 US US16/371,684 patent/US11136381B2/en active Active
- 2019-04-01 TW TW108111549A patent/TWI833742B/zh active
- 2019-04-01 AR ARP190100853A patent/AR117565A1/es unknown
- 2019-04-01 CA CA3093356A patent/CA3093356A1/en active Pending
- 2019-04-01 SG SG11202008897SA patent/SG11202008897SA/en unknown
- 2019-04-01 MX MX2020010323A patent/MX2020010323A/es unknown
- 2019-04-01 PE PE2020001505A patent/PE20212132A1/es unknown
-
2020
- 2020-09-16 IL IL277404A patent/IL277404A/en unknown
- 2020-09-29 CL CL2020002522A patent/CL2020002522A1/es unknown
- 2020-10-01 PH PH12020500664A patent/PH12020500664A1/en unknown
- 2020-10-26 CO CONC2020/0013468A patent/CO2020013468A2/es unknown
-
2021
- 2021-08-02 CL CL2021002039A patent/CL2021002039A1/es unknown
- 2021-08-19 US US17/406,991 patent/US11767359B2/en active Active
-
2023
- 2023-08-10 US US18/447,741 patent/US20230382985A1/en not_active Abandoned
-
2024
- 2024-02-13 JP JP2024019502A patent/JP2024056851A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031240A1 (en) * | 2002-10-04 | 2004-04-15 | Stichting Sanquin Bloedvoorziening | Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation |
| WO2010136311A2 (en) * | 2009-05-06 | 2010-12-02 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
Also Published As
| Publication number | Publication date |
|---|---|
| US11767359B2 (en) | 2023-09-26 |
| US20190322730A1 (en) | 2019-10-24 |
| TW202003559A (zh) | 2020-01-16 |
| CL2020002522A1 (es) | 2021-02-26 |
| RU2020135712A (ru) | 2022-05-04 |
| JP7477457B2 (ja) | 2024-05-01 |
| US11136381B2 (en) | 2021-10-05 |
| US20230382985A1 (en) | 2023-11-30 |
| PH12020500664A1 (en) | 2021-06-07 |
| MX2020010323A (es) | 2021-01-08 |
| BR112020019907A2 (pt) | 2021-01-05 |
| JP2021520195A (ja) | 2021-08-19 |
| EP3790897A1 (en) | 2021-03-17 |
| AR117565A1 (es) | 2021-08-18 |
| SG11202008897SA (en) | 2020-10-29 |
| CO2020013468A2 (es) | 2020-11-10 |
| JP2024056851A (ja) | 2024-04-23 |
| KR20200138290A (ko) | 2020-12-09 |
| IL277404A (en) | 2020-11-30 |
| CN112105638A (zh) | 2020-12-18 |
| US20220119508A1 (en) | 2022-04-21 |
| AU2019248557A1 (en) | 2020-09-24 |
| PE20212132A1 (es) | 2021-11-05 |
| CA3093356A1 (en) | 2019-10-10 |
| WO2019195136A1 (en) | 2019-10-10 |
| CL2021002039A1 (es) | 2022-04-01 |
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