JP7472143B2 - イオンチャネル阻害化合物を使用して過敏性咳またはかゆみを治療する方法 - Google Patents
イオンチャネル阻害化合物を使用して過敏性咳またはかゆみを治療する方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Description
政府の権利に関する声明
技術分野
R2、R1aおよびR1bは、本明細書に記載されているとおりである。
R1bは、F、Cl、およびCF3からなる群からそれぞれ独立して選択されるメンバーである。例示的な実施形態では、化合物は、
化学合成
医薬製剤
実施例
実施例A
モルモットの代表的な過敏性咳モデルにおけるEX/AFA化合物のin vivo効果
参照文献
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Irwin, R. S., M. J. Rosen and S. S. Braman (1977). "Cough. A comprehensive review." Arch Intern Med 137(9): 1186-1191.
Kase, Y., Y. Wakita, G. Kito, T. Miyata, T. Yuizono and M. Kataoka (1970).
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North, R. A. (2016). "P2X receptors." Philos Trans R Soc Load B Biol Sci 371(1700).
Pachuau, J, Martin- Caraballo, M. (2007). Expression pattern of T-type Ca(2+) channels in embryonic chick nodose ganglion neurons, Dev Neurobiol. 67(14);1901-14.
実施例B:マウスでの2つの代表的なかゆみモデルにおけるAFA/EX化合物のin vivo効果
追加の参照文献
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Claims (5)
- 前記過敏性咳が、COPD、喘息、胃食道逆流症、後鼻漏症候群、および汚染物質への慢性曝露からなる群から選択される疾患または症候群によって引き起こされる、請求項1に記載の組成物。
- 前記化合物が経口または経鼻的に投与される、請求項1に記載の組成物。
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PCT/US2019/048666 WO2020047168A1 (en) | 2018-08-28 | 2019-08-28 | Methods of treating hypersensitive cough or itching using ion channel inhibitory compounds |
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