JP7459058B2 - Cd137/her2二重特異性物質とpd-1系阻害物質とを含む併用療法およびその使用法 - Google Patents

Cd137/her2二重特異性物質とpd-1系阻害物質とを含む併用療法およびその使用法 Download PDF

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JP7459058B2
JP7459058B2 JP2021510824A JP2021510824A JP7459058B2 JP 7459058 B2 JP7459058 B2 JP 7459058B2 JP 2021510824 A JP2021510824 A JP 2021510824A JP 2021510824 A JP2021510824 A JP 2021510824A JP 7459058 B2 JP7459058 B2 JP 7459058B2
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her2 bispecific
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イングナー ブランズ
ルイス マティス
シェーン オルヴィル
トーマス ジャキン
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ピエリス ファーマシューティカルズ ゲーエムベーハー
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Health & Medical Sciences (AREA)
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JP2021510824A 2018-08-27 2019-08-27 Cd137/her2二重特異性物質とpd-1系阻害物質とを含む併用療法およびその使用法 Active JP7459058B2 (ja)

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EP18191041.5 2018-08-27
EP18191041 2018-08-27
PCT/EP2019/072754 WO2020043683A1 (en) 2018-08-27 2019-08-27 Combination therapies comprising cd137/her2 bispecific agents and pd-1 axis inhibitors and uses thereof

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JP2021535149A JP2021535149A (ja) 2021-12-16
JPWO2020043683A5 JPWO2020043683A5 (enExample) 2022-08-12
JP7459058B2 true JP7459058B2 (ja) 2024-04-01

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EP (1) EP3843849A1 (enExample)
JP (1) JP7459058B2 (enExample)
KR (1) KR20210052468A (enExample)
CN (1) CN112955221A (enExample)
AU (1) AU2019328632A1 (enExample)
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020253034A1 (en) * 2019-03-29 2021-08-19 Pieris Pharmaceuticals Gmbh Inhaled administration of lipocalin muteins
EP4110826A4 (en) * 2020-02-28 2024-08-14 Shanghai Henlius Biotech, Inc. ANTI-CD137 CONSTRUCTS, MULTI-SPECIFIC ANTIBODY AND ITS USES
US20230366884A1 (en) * 2020-09-18 2023-11-16 Pieris Pharmaceuticals Gmbh Biomarker methods and uses
WO2022158889A1 (en) * 2021-01-25 2022-07-28 Yuhan Corporation Methods for purifying an anti-4-1bb/anti-her2 bispecific antibody
EP4313099A2 (en) 2021-03-23 2024-02-07 Pieris Pharmaceuticals GmbH Her2/4-1bb bispecific fusion proteins for the treatment of cancer
CN118632872A (zh) * 2022-01-25 2024-09-10 美勒斯公司 用于治疗癌症的组合疗法
CN116120461B (zh) * 2022-04-29 2023-09-29 德琪(杭州)生物有限公司 新型抗药抗体以及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016508028A (ja) 2012-11-30 2016-03-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pd−l1阻害剤併用療法を必要とする患者の同定
JP2017507900A (ja) 2013-12-17 2017-03-23 ジェネンテック, インコーポレイテッド Pd−1軸結合アンタゴニスト及び抗her2抗体を使用してher2陽性がんを治療する方法
JP2018515085A (ja) 2015-05-04 2018-06-14 ピエリス ファーマシューティカルズ ゲーエムベーハー 抗がん融合ポリペプチド

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
EP1136556B1 (en) 1991-11-25 2005-06-08 Enzon, Inc. Method of producing multivalent antigen-binding proteins
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
WO2002086083A2 (en) 2001-04-20 2002-10-31 Mayo Foundation For Medical Education And Research Methods of enhancing cell responsiveness
WO2003042402A2 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US7595048B2 (en) 2002-07-03 2009-09-29 Ono Pharmaceutical Co., Ltd. Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
WO2004056875A1 (en) 2002-12-23 2004-07-08 Wyeth Antibodies against pd-1 and uses therefor
DK2161336T4 (en) 2005-05-09 2017-04-24 Ono Pharmaceutical Co Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies
BRPI0611766A2 (pt) 2005-06-08 2011-12-20 Dana Farber Cancer Inst Inc métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada
RS54271B1 (sr) 2005-07-01 2016-02-29 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1)
NZ582150A (en) 2007-06-18 2012-08-31 Msd Oss Bv Antibodies to human programmed death receptor pd-1
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
CN102203132A (zh) 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂的组合物和使用方法
HRP20170908T1 (hr) 2008-12-09 2017-09-22 F. Hoffmann - La Roche Ag Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice
WO2010089411A2 (en) 2009-02-09 2010-08-12 Universite De La Mediterranee Pd-1 antibodies and pd-l1 antibodies and uses thereof
PT2504364T (pt) 2009-11-24 2017-11-14 Medimmune Ltd Agentes de ligação direcionados contra b7-h1
EP2545078A1 (en) 2010-03-11 2013-01-16 UCB Pharma, S.A. Pd-1 antibody
CA2833636A1 (en) 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
EP2734551B1 (en) 2011-07-24 2018-01-10 Cure Tech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
RS61033B1 (sr) 2011-11-28 2020-12-31 Merck Patent Gmbh Antitela na pd-l1 i njihova upotreba
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
SG11201601844TA (en) 2013-09-13 2016-04-28 Beigene Ltd Anti-pd1 antibodies and their use as therapeutics and diagnostics
EP4285928A3 (en) 2013-09-27 2024-03-13 F. Hoffmann-La Roche AG Anti-pdl1 antibody formulations
US10202454B2 (en) 2013-10-25 2019-02-12 Dana-Farber Cancer Institute, Inc. Anti-PD-L1 monoclonal antibodies and fragments thereof
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
KR102360693B1 (ko) 2014-07-11 2022-02-08 벤타나 메디컬 시스템즈, 인코포레이티드 항-pd-l1 항체 및 이의 진단 용도
EP3206711B1 (en) 2014-10-14 2023-05-31 Novartis AG Antibody molecules to pd-l1 and uses thereof
CA2971734C (en) 2014-12-22 2025-11-18 Enumeral Biomedical Holdings Inc Anti-pd-1 antibodies
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
JP6432121B2 (ja) 2016-03-04 2018-12-05 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド Pdl−1抗体、その医薬組成物及びその使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016508028A (ja) 2012-11-30 2016-03-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pd−l1阻害剤併用療法を必要とする患者の同定
JP2017507900A (ja) 2013-12-17 2017-03-23 ジェネンテック, インコーポレイテッド Pd−1軸結合アンタゴニスト及び抗her2抗体を使用してher2陽性がんを治療する方法
JP2018515085A (ja) 2015-05-04 2018-06-14 ピエリス ファーマシューティカルズ ゲーエムベーハー 抗がん融合ポリペプチド

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US20210246219A1 (en) 2021-08-12
CN112955221A (zh) 2021-06-11
EP3843849A1 (en) 2021-07-07
AU2019328632A1 (en) 2021-03-25
CA3106881A1 (en) 2020-03-05
JP2021535149A (ja) 2021-12-16
WO2020043683A1 (en) 2020-03-05
KR20210052468A (ko) 2021-05-10

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