JP7454512B2 - 優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体 - Google Patents

優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体 Download PDF

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JP7454512B2
JP7454512B2 JP2020572638A JP2020572638A JP7454512B2 JP 7454512 B2 JP7454512 B2 JP 7454512B2 JP 2020572638 A JP2020572638 A JP 2020572638A JP 2020572638 A JP2020572638 A JP 2020572638A JP 7454512 B2 JP7454512 B2 JP 7454512B2
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methoxy
ethyl
pyridine
methoxyazetidin
cyclopropyl
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JP2021528455A (ja
JPWO2020002270A5 (enExample
Inventor
アメタミー，シモン・エム
アッツ，ケネス
ゴッビ，ルカ
グレター，ウーヴェ
グーバ，ヴォルフガング
クレッツ，ユリアン
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F Hoffmann La Roche AG
Eidgenoessische Technische Hochschule Zurich ETHZ
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F Hoffmann La Roche AG
Eidgenoessische Technische Hochschule Zurich ETHZ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/4866—Organic macromolecular compounds
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2020572638A 2018-06-27 2019-06-25 優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体 Active JP7454512B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18180114 2018-06-27
EP18180114.3 2018-06-27
PCT/EP2019/066733 WO2020002270A1 (en) 2018-06-27 2019-06-25 Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists

Publications (3)

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JP2021528455A JP2021528455A (ja) 2021-10-21
JPWO2020002270A5 JPWO2020002270A5 (enExample) 2022-06-30
JP7454512B2 true JP7454512B2 (ja) 2024-03-22

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US (1) US11655243B2 (enExample)
EP (1) EP3814337B1 (enExample)
JP (1) JP7454512B2 (enExample)
CN (1) CN112074513B (enExample)
WO (1) WO2020002270A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112199A1 (es) 2017-06-20 2019-10-02 Hoffmann La Roche Derivados de piridina como agonistas inversos del receptor cannabinoide 2
CN112119068A (zh) 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
SG11202009103WA (en) 2018-06-27 2020-10-29 Hoffmann La Roche Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
CN112638430B (zh) * 2018-06-27 2023-05-16 豪夫迈·罗氏有限公司 放射性标记的大麻素受体2配体

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010505788A (ja) 2006-10-04 2010-02-25 エフ．ホフマン−ラ ロシュ アーゲー Ｃｂ２受容体調節因子としてのピラジン−２−カルボキサミド誘導体
JP2014516071A (ja) 2011-06-10 2014-07-07 エフ．ホフマン−ラ ロシュ アーゲー Ｃｂ２アゴニストとして有用なピリジン−２−アミド
JP2014534210A (ja) 2011-10-28 2014-12-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規なピラジン誘導体
JP2016516737A (ja) 2013-03-26 2016-06-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ピリジン誘導体
JP2017509688A (ja) 2014-04-04 2017-04-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ カンナビノイド受容体アゴニストとしての５，６−二置換ピリジン−２−カルボキサミド
JP2022501311A (ja) 2018-06-27 2022-01-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 放射性標識カンナビノイド受容体２リガンド

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808769A (en) * 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
WO2009106561A1 (en) * 2008-02-27 2009-09-03 Biovitrum Ab (Publ) Pyrazine compounds for treating gpr119 related disorders
CA2844834A1 (en) * 2011-09-12 2013-03-21 F.Hoffmann-La Roche Ag 5-cycloalkyl- or 5-heterocyclyl-nicotinamides
TW201326139A (zh) * 2011-10-28 2013-07-01 Hoffmann La Roche 新穎吡□衍生物
MX2015007155A (es) * 2012-12-07 2015-10-14 Hoffmann La Roche Nuevos derivados de piridina.
BR112015013124A2 (pt) 2012-12-07 2017-07-11 Hoffmann La Roche novos derivados de piridina
US9303012B2 (en) 2012-12-07 2016-04-05 Hoffman-La Roche Inc. Pyridine-2-amides useful as CB2 agonists
LT2928882T (lt) 2012-12-07 2017-03-27 F. Hoffmann-La Roche Ag Pirazino dariniai kaip cb2 receptoriaus agonistai
MA39843A (fr) * 2014-04-04 2017-02-08 Hoffmann La Roche Pyridine-2-amides utiles comme agonistes de cb2
CA2999216A1 (en) 2015-12-09 2017-06-15 F. Hoffmann-La Roche Ag Phenyl derivatives as cannabinoid receptor 2 agonists
AR112199A1 (es) 2017-06-20 2019-10-02 Hoffmann La Roche Derivados de piridina como agonistas inversos del receptor cannabinoide 2
CN112119068A (zh) 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
SG11202009103WA (en) 2018-06-27 2020-10-29 Hoffmann La Roche Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
TWI687701B (zh) 2018-12-05 2020-03-11 宏碁股份有限公司 判斷電量狀態的方法及其電子裝置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010505788A (ja) 2006-10-04 2010-02-25 エフ．ホフマン−ラ ロシュ アーゲー Ｃｂ２受容体調節因子としてのピラジン−２−カルボキサミド誘導体
JP2014516071A (ja) 2011-06-10 2014-07-07 エフ．ホフマン−ラ ロシュ アーゲー Ｃｂ２アゴニストとして有用なピリジン−２−アミド
JP2014534210A (ja) 2011-10-28 2014-12-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規なピラジン誘導体
JP2016516737A (ja) 2013-03-26 2016-06-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ピリジン誘導体
JP2017509688A (ja) 2014-04-04 2017-04-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ カンナビノイド受容体アゴニストとしての５，６−二置換ピリジン−２−カルボキサミド
JP2022501311A (ja) 2018-06-27 2022-01-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 放射性標識カンナビノイド受容体２リガンド

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry ，2015年，Vol. 58, No. 10，p. 4266-4277

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EP3814337C0 (en) 2025-05-14
JP2021528455A (ja) 2021-10-21
WO2020002270A1 (en) 2020-01-02
US20210115027A1 (en) 2021-04-22
CN112074513B (zh) 2024-06-14
EP3814337A1 (en) 2021-05-05
EP3814337B1 (en) 2025-05-14
CN112074513A (zh) 2020-12-11
US11655243B2 (en) 2023-05-23

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