JP7442821B2 - メイタンシノイド系薬物送達システム - Google Patents

メイタンシノイド系薬物送達システム Download PDF

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Publication number
JP7442821B2
JP7442821B2 JP2020529491A JP2020529491A JP7442821B2 JP 7442821 B2 JP7442821 B2 JP 7442821B2 JP 2020529491 A JP2020529491 A JP 2020529491A JP 2020529491 A JP2020529491 A JP 2020529491A JP 7442821 B2 JP7442821 B2 JP 7442821B2
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cancer
pharmaceutically acceptable
hydrate
acceptable salt
compound
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JP2021505551A (ja
JP2021505551A5 (https=
Inventor
フェリクス クラッツ，
アジャアジャ， ハーリド アブ
アナ ワルネッケ，
フリーデリーケ イー． ノルマン，
シュテファン ダーヴィト ケスター，
フェルナンデス， ハビエル ガルシア
ララ ペス，
ハイディ－クリスティン ヴァルター，
ヨハネス パル マグヌソン，
セルゲイ チェルへジャ，
ガラン， パトリシア ぺレス
フェデリコ メダ，
シュテフェン ヨゼフ ダウム，
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センチュリオン バイオファーマ コーポレイション
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Priority to JP2023151472A priority Critical patent/JP2023164604A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020529491A 2017-11-30 2018-11-30 メイタンシノイド系薬物送達システム Active JP7442821B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023151472A JP2023164604A (ja) 2017-11-30 2023-09-19 メイタンシノイド系薬物送達システム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762593184P 2017-11-30 2017-11-30
US62/593,184 2017-11-30
PCT/US2018/063380 WO2019108975A1 (en) 2017-11-30 2018-11-30 Maytansinoid-based drug delivery systems

Related Child Applications (1)

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JP2023151472A Division JP2023164604A (ja) 2017-11-30 2023-09-19 メイタンシノイド系薬物送達システム

Publications (3)

Publication Number Publication Date
JP2021505551A JP2021505551A (ja) 2021-02-18
JP2021505551A5 JP2021505551A5 (https=) 2023-05-15
JP7442821B2 true JP7442821B2 (ja) 2024-03-05

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JP2020529491A Active JP7442821B2 (ja) 2017-11-30 2018-11-30 メイタンシノイド系薬物送達システム
JP2023151472A Pending JP2023164604A (ja) 2017-11-30 2023-09-19 メイタンシノイド系薬物送達システム

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JP2023151472A Pending JP2023164604A (ja) 2017-11-30 2023-09-19 メイタンシノイド系薬物送達システム

Country Status (11)

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US (2) US11572373B2 (https=)
EP (1) EP3717018A1 (https=)
JP (2) JP7442821B2 (https=)
KR (1) KR20200117988A (https=)
CN (1) CN111712263B (https=)
AU (1) AU2018375788A1 (https=)
BR (1) BR112020010989A2 (https=)
CA (1) CA3083985A1 (https=)
IL (2) IL274920B2 (https=)
MX (1) MX2020005472A (https=)
WO (1) WO2019108975A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6948708B2 (ja) 2015-06-19 2021-10-13 センチュリオン バイオファーマ コーポレイション 薬物制御放出のための送達系
EP4344747A3 (en) 2017-11-30 2024-07-03 LadRx Corporation Albumin-binding prodrugs of auristatin e derivatives
CN110227164B (zh) 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用
JP2024546948A (ja) 2021-12-15 2024-12-26 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド コンジュゲート、それらの組成物、及びそれらの関連する方法

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JP2003501486A (ja) 1999-06-09 2003-01-14 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 注射可能な医薬調製剤の製法
JP2016501859A (ja) 2012-11-24 2016-01-21 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
WO2016160615A1 (en) 2015-03-27 2016-10-06 Regeneron Pharmaceuticals, Inc. Maytansinoid derivatives, conjugates thereof, and methods of use
WO2016205738A2 (en) 2015-06-19 2016-12-22 Cytrx Corporation Delivery systems for controlled drug release

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ATE243754T1 (de) 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
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EP4344747A3 (en) 2017-11-30 2024-07-03 LadRx Corporation Albumin-binding prodrugs of auristatin e derivatives

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2003501486A (ja) 1999-06-09 2003-01-14 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 注射可能な医薬調製剤の製法
JP2016501859A (ja) 2012-11-24 2016-01-21 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
WO2016160615A1 (en) 2015-03-27 2016-10-06 Regeneron Pharmaceuticals, Inc. Maytansinoid derivatives, conjugates thereof, and methods of use
WO2016205738A2 (en) 2015-06-19 2016-12-22 Cytrx Corporation Delivery systems for controlled drug release

Also Published As

Publication number Publication date
EP3717018A1 (en) 2020-10-07
IL274920B1 (en) 2023-09-01
US20200385403A1 (en) 2020-12-10
RU2020121456A (ru) 2021-12-30
CN111712263A (zh) 2020-09-25
AU2018375788A1 (en) 2020-07-09
JP2021505551A (ja) 2021-02-18
BR112020010989A2 (pt) 2020-11-17
CA3083985A1 (en) 2019-06-06
WO2019108975A1 (en) 2019-06-06
US11572373B2 (en) 2023-02-07
CN111712263B (zh) 2024-12-17
JP2023164604A (ja) 2023-11-10
IL274920A (en) 2020-07-30
US20230391794A1 (en) 2023-12-07
MX2020005472A (es) 2020-11-11
KR20200117988A (ko) 2020-10-14
IL274920B2 (en) 2024-01-01
RU2020121456A3 (https=) 2022-04-13
IL305268A (en) 2023-10-01

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