KR20200117988A - 메이탄시노이드계 약물 전달 시스템 - Google Patents

메이탄시노이드계 약물 전달 시스템 Download PDF

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Publication number
KR20200117988A
KR20200117988A KR1020207018379A KR20207018379A KR20200117988A KR 20200117988 A KR20200117988 A KR 20200117988A KR 1020207018379 A KR1020207018379 A KR 1020207018379A KR 20207018379 A KR20207018379 A KR 20207018379A KR 20200117988 A KR20200117988 A KR 20200117988A
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South Korea
Prior art keywords
compound
cancer
group
alkyl
carcinoma
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Ceased
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KR1020207018379A
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English (en)
Korean (ko)
Inventor
필릭스 크라츠
아자즈 칼리드 아부
안나 워네케
프리데리케 아이. 놀만
스테판 데이비드 퀘스터
페르난데즈 자비에 가르시아
라라 페스
하이디-크리스틴 월터
요하네스 팔 매그너슨
세르게이 체르체아
갈란 패트리샤 페레즈
페데리코 메다
스테판 요세프 다움
Original Assignee
센추리온 바이오파마 코포레이션
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Publication of KR20200117988A publication Critical patent/KR20200117988A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207018379A 2017-11-30 2018-11-30 메이탄시노이드계 약물 전달 시스템 Ceased KR20200117988A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762593184P 2017-11-30 2017-11-30
US62/593,184 2017-11-30
PCT/US2018/063380 WO2019108975A1 (en) 2017-11-30 2018-11-30 Maytansinoid-based drug delivery systems

Publications (1)

Publication Number Publication Date
KR20200117988A true KR20200117988A (ko) 2020-10-14

Family

ID=64744962

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207018379A Ceased KR20200117988A (ko) 2017-11-30 2018-11-30 메이탄시노이드계 약물 전달 시스템

Country Status (11)

Country Link
US (2) US11572373B2 (https=)
EP (1) EP3717018A1 (https=)
JP (2) JP7442821B2 (https=)
KR (1) KR20200117988A (https=)
CN (1) CN111712263B (https=)
AU (1) AU2018375788A1 (https=)
BR (1) BR112020010989A2 (https=)
CA (1) CA3083985A1 (https=)
IL (2) IL274920B2 (https=)
MX (1) MX2020005472A (https=)
WO (1) WO2019108975A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6948708B2 (ja) 2015-06-19 2021-10-13 センチュリオン バイオファーマ コーポレイション 薬物制御放出のための送達系
EP4344747A3 (en) 2017-11-30 2024-07-03 LadRx Corporation Albumin-binding prodrugs of auristatin e derivatives
CN110227164B (zh) 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用
JP2024546948A (ja) 2021-12-15 2024-12-26 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド コンジュゲート、それらの組成物、及びそれらの関連する方法

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GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
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EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
CA2115811A1 (en) 1993-02-17 1994-08-18 Claus Krebber A method for in vivo selection of ligand-binding proteins
DE19926154A1 (de) 1999-06-09 2000-12-14 Ktb Tumorforschungs Gmbh Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
NZ547370A (en) 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
CN101743020A (zh) 2007-05-16 2010-06-16 Ktb肿瘤研究有限责任公司 低粘度蒽环制剂
EP2289558A1 (en) 2009-08-25 2011-03-02 KTB Tumorforschungsgesellschaft mbH Bisphosphonate-prodrugs
WO2012145112A2 (en) * 2011-04-18 2012-10-26 Immunogen, Inc. Novel maytansinoid derivatives with sulfoxide linker
CN104185477B (zh) 2011-11-17 2017-05-24 辉瑞公司 细胞毒性肽及其抗体‑药物缀合物
EP2630971B8 (en) 2012-02-21 2017-12-13 Vergell Medical S.A. Combinations of albumin-based drug delivery systems
CA2891280C (en) * 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
CN104688740A (zh) 2012-12-21 2015-06-10 百奥泰生物科技(广州)有限公司 类美登素衍生物及其制备方法和用途
US20140221429A1 (en) 2013-02-04 2014-08-07 Saud Ibrahim Al-Resayes Heterocyclic schiff's bases as novel and new antiglycation agents
EP3566750A3 (en) * 2013-02-28 2020-04-08 ImmunoGen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
BR112017020149A8 (pt) * 2015-03-27 2023-05-02 Regeneron Pharma Derivados de maitansinoide, conjugados dos mesmos e métodos de uso
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JP6948708B2 (ja) * 2015-06-19 2021-10-13 センチュリオン バイオファーマ コーポレイション 薬物制御放出のための送達系
EP4344747A3 (en) 2017-11-30 2024-07-03 LadRx Corporation Albumin-binding prodrugs of auristatin e derivatives

Also Published As

Publication number Publication date
EP3717018A1 (en) 2020-10-07
IL274920B1 (en) 2023-09-01
US20200385403A1 (en) 2020-12-10
RU2020121456A (ru) 2021-12-30
CN111712263A (zh) 2020-09-25
AU2018375788A1 (en) 2020-07-09
JP2021505551A (ja) 2021-02-18
JP7442821B2 (ja) 2024-03-05
BR112020010989A2 (pt) 2020-11-17
CA3083985A1 (en) 2019-06-06
WO2019108975A1 (en) 2019-06-06
US11572373B2 (en) 2023-02-07
CN111712263B (zh) 2024-12-17
JP2023164604A (ja) 2023-11-10
IL274920A (en) 2020-07-30
US20230391794A1 (en) 2023-12-07
MX2020005472A (es) 2020-11-11
IL274920B2 (en) 2024-01-01
RU2020121456A3 (https=) 2022-04-13
IL305268A (en) 2023-10-01

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