JP7440102B2 - 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用 - Google Patents

新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用 Download PDF

Info

Publication number
JP7440102B2
JP7440102B2 JP2021520275A JP2021520275A JP7440102B2 JP 7440102 B2 JP7440102 B2 JP 7440102B2 JP 2021520275 A JP2021520275 A JP 2021520275A JP 2021520275 A JP2021520275 A JP 2021520275A JP 7440102 B2 JP7440102 B2 JP 7440102B2
Authority
JP
Japan
Prior art keywords
domain
seq
fusion protein
cells
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021520275A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019246379A5 (https=
JP2021528104A (ja
JP2021528104A5 (https=
Inventor
リ，ユエシェン
ルイ，リンユン
ス，ジン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cugene Inc
Original Assignee
Cugene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cugene Inc filed Critical Cugene Inc
Publication of JP2021528104A publication Critical patent/JP2021528104A/ja
Publication of JPWO2019246379A5 publication Critical patent/JPWO2019246379A5/ja
Publication of JP2021528104A5 publication Critical patent/JP2021528104A5/ja
Priority to JP2024016792A priority Critical patent/JP7741574B2/ja
Application granted granted Critical
Publication of JP7440102B2 publication Critical patent/JP7440102B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2021520275A 2018-06-22 2019-06-20 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用 Active JP7440102B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024016792A JP7741574B2 (ja) 2018-06-22 2024-02-07 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689051P 2018-06-22 2018-06-22
US62/689,051 2018-06-22
PCT/US2019/038210 WO2019246379A1 (en) 2018-06-22 2019-06-20 Novel interleukin-15 (1l-15) fusion proteins and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024016792A Division JP7741574B2 (ja) 2018-06-22 2024-02-07 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Publications (4)

Publication Number Publication Date
JP2021528104A JP2021528104A (ja) 2021-10-21
JPWO2019246379A5 JPWO2019246379A5 (https=) 2022-06-23
JP2021528104A5 JP2021528104A5 (https=) 2022-06-23
JP7440102B2 true JP7440102B2 (ja) 2024-02-28

Family

ID=68984274

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021520275A Active JP7440102B2 (ja) 2018-06-22 2019-06-20 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用
JP2024016792A Active JP7741574B2 (ja) 2018-06-22 2024-02-07 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024016792A Active JP7741574B2 (ja) 2018-06-22 2024-02-07 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Country Status (8)

Country Link
US (2) US12319722B2 (https=)
EP (1) EP3810171B1 (https=)
JP (2) JP7440102B2 (https=)
KR (2) KR102848197B1 (https=)
CN (2) CN121086085A (https=)
AU (2) AU2019288471B2 (https=)
CA (1) CA3102821A1 (https=)
WO (1) WO2019246379A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023506452A (ja) * 2019-12-13 2023-02-16 キュージーン インコーポレイテッド 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24546B1 (es) * 2016-12-30 2021-09-07 Ct Ingenieria Genetica Biotecnologia Composición vacunal que comprende un mutante de la interleucina-15 humana
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
CN109705211B (zh) 2017-10-26 2020-08-18 苏州复融生物技术有限公司 一种IgG1 Fc单体及其应用
CN120463822A (zh) 2018-09-27 2025-08-12 西里欧发展公司 掩蔽型细胞因子多肽
IL297326A (en) * 2020-04-22 2022-12-01 Novartis Ag Pharmaceutical preparations and pharmaceutical products of human interleukin-15 hydrometers (ethyl-15)
KR20250140647A (ko) * 2020-08-03 2025-09-25 난트셀, 인크. Il-15 초작용제에 대한 약물-특이적 약동학 검정
WO2022045849A1 (ko) * 2020-08-31 2022-03-03 주식회사 지아이셀 Il15 단백질, il15 수용체 알파 단백질, fc 도메인 및 il2 단백질을 포함하는 융합단백질 및 이의 용도
AU2021345852A1 (en) * 2020-09-16 2023-05-25 Beone Medicines I Gmbh Interleukin 15 constructs and methods of use
WO2022115865A2 (en) 2020-11-25 2022-06-02 Xilio Development, Inc. Tumor-specific cleavable linkers
CN113321736B (zh) * 2020-12-30 2024-01-09 苏州复融生物技术有限公司 一种长效化白介素15融合蛋白及其制备方法和应用
WO2022232321A1 (en) * 2021-04-28 2022-11-03 Minotaur Therapeutics, Inc. Humanized chimeric bovine antibodies and methods of use
CN113321740B (zh) * 2021-05-08 2023-07-18 上海交通大学 一种融合蛋白及其制备方法和用途
US20250115657A1 (en) * 2021-05-28 2025-04-10 Akso Biopharmaceutical, Inc. Bispecific FC Fusion Proteins with sPD-1 and IL-15
CN116655771A (zh) * 2021-05-28 2023-08-29 苏州复融生物技术有限公司 一种新型白介素15突变体多肽的开发及其应用
US20240350589A1 (en) 2021-08-13 2024-10-24 Cytune Pharma Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
CN116023503B (zh) * 2021-10-25 2024-05-31 上海交通大学 一种融合蛋白及其制备方法和用途
WO2023083379A1 (zh) * 2021-11-15 2023-05-19 中国科学院生物物理研究所 一种以白介素15为活性成份的融合蛋白构建体及其应用
CN115141283A (zh) * 2022-03-10 2022-10-04 厦门柏慈生物科技有限公司 一种融合蛋白、制备方法及其应用
WO2024031036A2 (en) * 2022-08-05 2024-02-08 Staidson Biopharma Inc. Il-15 prodrug and uses thereof
US20260083832A1 (en) * 2022-10-28 2026-03-26 Nant Holdings Ip, Llc Vaccine Composition For Stimulation Of Broad Spectrum Memory B Cell Expansion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257361A1 (en) 2005-04-12 2006-11-16 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Novel form of interleukin-15, Fc-IL-15, and methods of use
JP2013541335A (ja) 2010-09-21 2013-11-14 アルター・バイオサイエンス・コーポレーション 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4213224B2 (ja) 1997-05-02 2009-01-21 ジェネンテック，インコーポレーテッド ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
US20060236411A1 (en) 2002-10-14 2006-10-19 Ingeborg Dreher Antagonists il-15
EP1718670B1 (en) 2004-02-27 2011-07-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
NZ582330A (en) 2007-06-27 2012-05-25 Marinepolymer Tech Inc COMPLEXES OF IL-15 AND IL-15Ra (RECEPTOR ALPHA) AND USES THEREOF
EP3470431A1 (en) 2012-09-27 2019-04-17 Merus N.V. Bispecific igg antibodies as t cell engagers
NZ630790A (en) 2012-10-24 2016-11-25 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
RU2689717C2 (ru) * 2014-01-08 2019-05-28 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Гетеродимерный белок il-15 и его применения
WO2016018920A1 (en) 2014-07-29 2016-02-04 Admune Therapeutics Llc Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions
AU2015366795B2 (en) 2014-12-19 2020-12-17 Jiangsu Hengrui Medicine Co., Ltd. Interleukin 15 protein complex and use thereof
CN112574316A (zh) 2015-07-02 2021-03-30 博际生物医药科技(杭州)有限公司 用于肿瘤靶向治疗的白细胞介素-15融合蛋白
EP3350205A1 (en) 2015-09-16 2018-07-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases
CN110214147A (zh) 2016-10-14 2019-09-06 Xencor股份有限公司 IL15/IL15Rα异源二聚体FC-融合蛋白
US11084863B2 (en) 2017-06-30 2021-08-10 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257361A1 (en) 2005-04-12 2006-11-16 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Novel form of interleukin-15, Fc-IL-15, and methods of use
JP2013541335A (ja) 2010-09-21 2013-11-14 アルター・バイオサイエンス・コーポレーション 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cytokine and Growth Factor Reviews，2017年09月01日，Vol.38，pp.10-21

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023506452A (ja) * 2019-12-13 2023-02-16 キュージーン インコーポレイテッド 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用
JP7807076B2 (ja) 2019-12-13 2026-01-27 キュージーン インコーポレイテッド 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用

Also Published As

Publication number Publication date
US20220106374A1 (en) 2022-04-07
EP3810171C0 (en) 2025-07-09
CN112584851B (zh) 2025-09-05
JP7741574B2 (ja) 2025-09-18
KR20250130696A (ko) 2025-09-02
EP3810171B1 (en) 2025-07-09
WO2019246379A1 (en) 2019-12-26
KR20210033994A (ko) 2021-03-29
EP3810171A4 (en) 2022-04-06
AU2025201175A1 (en) 2025-03-13
EP3810171A1 (en) 2021-04-28
CN121086085A (zh) 2025-12-09
KR102848197B1 (ko) 2025-08-21
US12319722B2 (en) 2025-06-03
US20250388641A1 (en) 2025-12-25
JP2021528104A (ja) 2021-10-21
JP2024063004A (ja) 2024-05-10
AU2019288471A1 (en) 2021-01-14
AU2019288471B2 (en) 2024-11-21
CA3102821A1 (en) 2019-12-26
CN112584851A (zh) 2021-03-30

Similar Documents

Publication Publication Date Title
JP7440102B2 (ja) 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用
JP7807076B2 (ja) 新規インターロイキン－１５（ｉｌ－１５）融合タンパク質およびその使用
AU2020291942B2 (en) Novel interleukin-2 variants for the treatment of cancer
JP7850417B2 (ja) 新規インターロイキン－２バリアントおよびその二官能性融合分子
RU2833537C2 (ru) Новые варианты интерлейкина-2 для лечения рака
JP2025531804A (ja) 新規のｐｄ１標的化ｉｌ－２免疫サイトカインおよびｖｉｔｏｋｉｎｅ融合物
HK40074638B (zh) 用於癌症治疗的新型白介素-2变体
HK40074638A (en) Novel interleukin-2 variants for the treatment of cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220615

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220615

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230425

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230718

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231025

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240109

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240207

R150 Certificate of patent or registration of utility model

Ref document number: 7440102

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150