JP7413368B2 - モノアシルグリセロールリパーゼ調節因子 - Google Patents

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Publication number

JP7413368B2

JP7413368B2 JP2021517338A JP2021517338A JP7413368B2 JP 7413368 B2 JP7413368 B2 JP 7413368B2 JP 2021517338 A JP2021517338 A JP 2021517338A JP 2021517338 A JP2021517338 A JP 2021517338A JP 7413368 B2 JP7413368 B2 JP 7413368B2

Authority

JP

Japan

Prior art keywords

methyl

hexahydro

epiminocycloocta

methanone

pyrazol

Prior art date

2018-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 102000005398 Monoacylglycerol Lipase Human genes 0.000 title description 68
• 108020002334 Monoacylglycerol lipase Proteins 0.000 title description 68
• 150000001875 compounds Chemical class 0.000 claims description 557
• -1 N(C=O)CH 3 Chemical group 0.000 claims description 499
• WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 220
• 125000000217 alkyl group Chemical group 0.000 claims description 189
• 229910052739 hydrogen Inorganic materials 0.000 claims description 88
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 65
• 150000003839 salts Chemical class 0.000 claims description 58
• 229910052799 carbon Inorganic materials 0.000 claims description 39
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 37
• 125000001072 heteroaryl group Chemical group 0.000 claims description 36
• 239000012453 solvate Substances 0.000 claims description 34
• 150000001204 N-oxides Chemical class 0.000 claims description 33
• 125000001424 substituent group Chemical group 0.000 claims description 31
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
• 125000001188 haloalkyl group Chemical group 0.000 claims description 25
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 23
• 229910052757 nitrogen Inorganic materials 0.000 claims description 23
• 229910052731 fluorine Inorganic materials 0.000 claims description 22
• 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims description 20
• 229910052801 chlorine Inorganic materials 0.000 claims description 18
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 16
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
• 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 15
• 125000004076 pyridyl group Chemical group 0.000 claims description 13
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 11
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
• 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 6
• 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 5
• 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims description 5
• 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 5
• 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 5
• 229910052794 bromium Inorganic materials 0.000 claims description 4
• ZIYVWOCHDPPRQB-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ZIYVWOCHDPPRQB-APWZRJJASA-N 0.000 claims description 3
• HPNWDHDDCVRIPG-JPYJTQIMSA-N (4-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 HPNWDHDDCVRIPG-JPYJTQIMSA-N 0.000 claims description 3
• XDVYLRGGKQYXSW-OFNKIYASSA-N [(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 XDVYLRGGKQYXSW-OFNKIYASSA-N 0.000 claims description 3
• JSTXJKQJHPPMNZ-OFNKIYASSA-N [(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC1=CC=C(C=C1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 JSTXJKQJHPPMNZ-OFNKIYASSA-N 0.000 claims description 3
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 3
• UYQHZWKFJGZZBM-AEFFLSMTSA-N (1,4-dimethylpyrazol-3-yl)-[(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C(C(=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 UYQHZWKFJGZZBM-AEFFLSMTSA-N 0.000 claims description 2
• UUBAEQMFLZTPPX-IRLDBZIGSA-N (1-benzyl-1,2,4-triazol-3-yl)-[(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C1=CC=CC=C1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 UUBAEQMFLZTPPX-IRLDBZIGSA-N 0.000 claims description 2
• FLDNYTKEKCUQAU-JPYJTQIMSA-N (1-methylindol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=CC2=C(C=CC=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 FLDNYTKEKCUQAU-JPYJTQIMSA-N 0.000 claims description 2
• OQEOJLWLRWDGGS-APWZRJJASA-N (2-amino-1,3-benzoxazol-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1OC2=C(N=1)C=CC(=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 OQEOJLWLRWDGGS-APWZRJJASA-N 0.000 claims description 2
• BQULOSOPSNXQGL-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)F)C)[C@@H]1CCC2 BQULOSOPSNXQGL-APWZRJJASA-N 0.000 claims description 2
• TWLFLJJQGNUSMF-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 TWLFLJJQGNUSMF-APWZRJJASA-N 0.000 claims description 2
• YSUQHTKAGRVBQK-GGAORHGYSA-N (3-imidazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 YSUQHTKAGRVBQK-GGAORHGYSA-N 0.000 claims description 2
• KLTMYKUSHJCLRE-BEFAXECRSA-N (4-chloro-1H-pyrrolo[2,3-b]pyridin-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C2C(=NC=C1C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC=CC=C4)C)[C@@H]1CCC3)NC=C2 KLTMYKUSHJCLRE-BEFAXECRSA-N 0.000 claims description 2
• WCEAPYPDSWPKOQ-JPYJTQIMSA-N (4-chloroquinolin-6-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 WCEAPYPDSWPKOQ-JPYJTQIMSA-N 0.000 claims description 2
• ZAHTYSSHIVUTIH-BEFAXECRSA-N (4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C2C(=NC=C1C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC=CC=C4)C)[C@@H]1CCC3)NC=C2 ZAHTYSSHIVUTIH-BEFAXECRSA-N 0.000 claims description 2
• ZKONBDSQJCFLDX-APWZRJJASA-N (5-aminopyridin-2-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1C=CC(=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 ZKONBDSQJCFLDX-APWZRJJASA-N 0.000 claims description 2
• JNRDRTNNAGZSQT-PBHICJAKSA-N (5-chloro-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 JNRDRTNNAGZSQT-PBHICJAKSA-N 0.000 claims description 2
• SWSONSGLFXJJIH-VGSWGCGISA-N (5-chloro-1H-indol-6-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=C2C=CNC2=CC=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 SWSONSGLFXJJIH-VGSWGCGISA-N 0.000 claims description 2
• ABZLOKFORXLDQN-XLIONFOSSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ABZLOKFORXLDQN-XLIONFOSSA-N 0.000 claims description 2
• QTQGIJHIKJISJS-RDGATRHJSA-N (5-cyclopropyl-1-phenylpyrazol-4-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 QTQGIJHIKJISJS-RDGATRHJSA-N 0.000 claims description 2
• MZSUQKXMJRRSQS-APWZRJJASA-N (5-cyclopropyl-1H-pyrazol-4-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 MZSUQKXMJRRSQS-APWZRJJASA-N 0.000 claims description 2
• NMTXGFOHHDBDSC-QAPCUYQASA-N (5-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 NMTXGFOHHDBDSC-QAPCUYQASA-N 0.000 claims description 2
• VBFJWMRAOCWYNA-OFNKIYASSA-N (5-methoxy-1-phenylpyrazol-3-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 VBFJWMRAOCWYNA-OFNKIYASSA-N 0.000 claims description 2
• SUMLJNNGEBCOKU-CTNGQTDRSA-N (7-methyl-1H-indazol-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=C(C=C2C=NNC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 SUMLJNNGEBCOKU-CTNGQTDRSA-N 0.000 claims description 2
• 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims description 2
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 2
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 2
• OMRIFXBBGZBOCC-GCJKJVERSA-N 6-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-1H-quinolin-4-one Chemical compound OC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 OMRIFXBBGZBOCC-GCJKJVERSA-N 0.000 claims description 2
• ZKCOGWDAZHCDSI-RDGATRHJSA-N [(1S,8R)-4-cyclopropyl-5-(3-fluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound C1(CC1)N1N=C2C(=C1C1=CC(=CC=C1)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 ZKCOGWDAZHCDSI-RDGATRHJSA-N 0.000 claims description 2
• XTHICEHCXHRCAQ-ZBFHGGJFSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 XTHICEHCXHRCAQ-ZBFHGGJFSA-N 0.000 claims description 2
• WISHDWNJDGSLMM-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methylpyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 WISHDWNJDGSLMM-UTKZUKDTSA-N 0.000 claims description 2
• NUBCSOOBBRZRJO-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methylpyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1C=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 NUBCSOOBBRZRJO-UTKZUKDTSA-N 0.000 claims description 2
• PAVXQOCCFZCZMI-CTNGQTDRSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=NN(C=N1)C1=CC=CC=C1 PAVXQOCCFZCZMI-CTNGQTDRSA-N 0.000 claims description 2
• YIOXWQULFGEGPF-OFNKIYASSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenylpyrazol-3-yl)methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=NN(C=C1)C1=CC=CC=C1 YIOXWQULFGEGPF-OFNKIYASSA-N 0.000 claims description 2
• PXLRUFWKWINRMY-AEFFLSMTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[1,5-a]pyridin-5-yl)methanone Chemical compound N=1C=NN2C=1C=CC=C2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 PXLRUFWKWINRMY-AEFFLSMTSA-N 0.000 claims description 2
• BTUQNOJKVBZKIH-GCJKJVERSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 BTUQNOJKVBZKIH-GCJKJVERSA-N 0.000 claims description 2
• GFBDPLNOSDXAHI-XLIONFOSSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(trifluoromethyl)-1,8-naphthyridin-3-yl]methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C(=NC2=NC=CC=C2C=1)C(F)(F)F GFBDPLNOSDXAHI-XLIONFOSSA-N 0.000 claims description 2
• RTERZJOQNPMPAP-IRLDBZIGSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 RTERZJOQNPMPAP-IRLDBZIGSA-N 0.000 claims description 2
• ZMSVXHVARRPOOK-IRLDBZIGSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=CC=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ZMSVXHVARRPOOK-IRLDBZIGSA-N 0.000 claims description 2
• SBSCNBYELAVCPM-UTKZUKDTSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1H-1,2,4-triazol-5-yl)phenyl]methanone Chemical compound N1N=CN=C1C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 SBSCNBYELAVCPM-UTKZUKDTSA-N 0.000 claims description 2
• QIKQZDQLKVCZTG-GCJKJVERSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 QIKQZDQLKVCZTG-GCJKJVERSA-N 0.000 claims description 2
• KKKQZMAFAZDGHH-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 KKKQZMAFAZDGHH-IRLDBZIGSA-N 0.000 claims description 2
• FSYNGJIZQRTJGN-GGAORHGYSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(3-pyrazol-1-ylphenyl)methanone Chemical compound N1(N=CC=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 FSYNGJIZQRTJGN-GGAORHGYSA-N 0.000 claims description 2
• SPEAHADODNSPJL-CTNGQTDRSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-(3-chlorophenyl)-1,2,4-triazol-3-yl]methanone Chemical compound ClC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 SPEAHADODNSPJL-CTNGQTDRSA-N 0.000 claims description 2
• XWDGISPRYNTBPG-GCJKJVERSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-chloro-5-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound ClC1=C(C=C(C=C1)N1C=NN=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 XWDGISPRYNTBPG-GCJKJVERSA-N 0.000 claims description 2
• UCWVSSSHPOULGQ-IRLDBZIGSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 UCWVSSSHPOULGQ-IRLDBZIGSA-N 0.000 claims description 2
• GBHNIFLOXGZILO-GGAORHGYSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1H-pyrazol-4-yl)phenyl]methanone Chemical compound N1N=CC(=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 GBHNIFLOXGZILO-GGAORHGYSA-N 0.000 claims description 2
• HHOKJUWUYFOCEN-CTNGQTDRSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(tetrazol-1-yl)phenyl]methanone Chemical compound N1(N=NN=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 HHOKJUWUYFOCEN-CTNGQTDRSA-N 0.000 claims description 2
• KLNLWOKKDKRIQS-IRLDBZIGSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C1=CC=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 KLNLWOKKDKRIQS-IRLDBZIGSA-N 0.000 claims description 2
• VHOTYKSATLJGFZ-OFNKIYASSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 VHOTYKSATLJGFZ-OFNKIYASSA-N 0.000 claims description 2
• QBLGRFBMMPNLBT-CTNGQTDRSA-N [(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C=N1)C1=CC=CC=C1 QBLGRFBMMPNLBT-CTNGQTDRSA-N 0.000 claims description 2
• XXKMBABMWSXVBU-GCJKJVERSA-N [(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 XXKMBABMWSXVBU-GCJKJVERSA-N 0.000 claims description 2
• IBICNCNPGNRPLE-UZLBHIALSA-N [2-(5-chloro-1H-1,2,4-triazol-3-yl)phenyl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=NC(=NN1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 IBICNCNPGNRPLE-UZLBHIALSA-N 0.000 claims description 2
• XCEAPQVSARFZLX-XLIONFOSSA-N [3-cyclopropyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2)CC(F)(F)F XCEAPQVSARFZLX-XLIONFOSSA-N 0.000 claims description 2
• FENXXKPOIXTISX-HIFRSBDPSA-N [4-bromo-2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C(=NN(C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2)C)C(F)(F)F FENXXKPOIXTISX-HIFRSBDPSA-N 0.000 claims description 2
• WQMUHNCYLFCFEM-NQIIRXRSSA-N [5-cyclopropyl-1-(2-hydroxyethyl)pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1CCO)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 WQMUHNCYLFCFEM-NQIIRXRSSA-N 0.000 claims description 2
• 125000004551 isoquinolin-3-yl group Chemical group C1=NC(=CC2=CC=CC=C12)* 0.000 claims description 2
• 125000004547 quinazolin-6-yl group Chemical group N1=CN=CC2=CC(=CC=C12)* 0.000 claims description 2
• 125000001475 halogen functional group Chemical group 0.000 claims 9
• QSLOKEHAMWJXEF-ZHRRBRCNSA-N [(1S,8R)-5-(3,5-difluoro-4-methoxyphenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)OC)F)C)[C@@H]1CCC2 QSLOKEHAMWJXEF-ZHRRBRCNSA-N 0.000 claims 2
• CLLSRYUCUFLWKX-VFNWGFHPSA-N [4-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 CLLSRYUCUFLWKX-VFNWGFHPSA-N 0.000 claims 2
• VMSHGFHYFZVTSU-VFNWGFHPSA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 VMSHGFHYFZVTSU-VFNWGFHPSA-N 0.000 claims 2
• JSTMUBIVINYHMT-ACJLOTCBSA-N (1,5-dimethylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC(=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 JSTMUBIVINYHMT-ACJLOTCBSA-N 0.000 claims 1
• DUTXTOWDMVGKGV-QRWLVFNGSA-N (1-cyclopropyl-3-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)N1N=C(C(=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C DUTXTOWDMVGKGV-QRWLVFNGSA-N 0.000 claims 1
• CFUHMYWXLDHWDB-QRWLVFNGSA-N (1-cyclopropyl-5-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)N1N=CC(=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 CFUHMYWXLDHWDB-QRWLVFNGSA-N 0.000 claims 1
• GWCNNMCJPPEJPT-ACJLOTCBSA-N (1-methylpyrazolo[3,4-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GWCNNMCJPPEJPT-ACJLOTCBSA-N 0.000 claims 1
• OKULNJZMDNWODB-YJYMSZOUSA-N (1-methylpyrazolo[3,4-b]pyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OKULNJZMDNWODB-YJYMSZOUSA-N 0.000 claims 1
• GPWZUDCSWJWCBM-PXAZEXFGSA-N (1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC=2C1=NC=NC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GPWZUDCSWJWCBM-PXAZEXFGSA-N 0.000 claims 1
• DDLKOLSDQUNKHU-VLIAUNLRSA-N (1-methylpyrrolo[2,3-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DDLKOLSDQUNKHU-VLIAUNLRSA-N 0.000 claims 1
• HBAQDEJGMLYXRY-VLIAUNLRSA-N (1-methylpyrrolo[2,3-b]pyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HBAQDEJGMLYXRY-VLIAUNLRSA-N 0.000 claims 1
• SNWXFJBSGGNIDS-UZLBHIALSA-N (2,7-dimethylimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1N=C2N(C=CC(=C2)C)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 SNWXFJBSGGNIDS-UZLBHIALSA-N 0.000 claims 1
• VYGUZLXROVRBEK-BEFAXECRSA-N (2,7-dimethylimidazo[1,2-b]pyridazin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1N=C2N(N=CC(=C2)C)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 VYGUZLXROVRBEK-BEFAXECRSA-N 0.000 claims 1
• ANEHJIIOBFCNGB-QRWLVFNGSA-N (2,7-dimethylpyrazolo[1,5-a]pyrimidin-5-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=NN2C(N=C(C=C2C)C(=O)N2[C@H]3CC=4C(=NN(C=4C4=CC(=C(C(=C4)F)F)F)C)[C@@H]2CCC3)=C1 ANEHJIIOBFCNGB-QRWLVFNGSA-N 0.000 claims 1
• ZIYVWOCHDPPRQB-QFBILLFUSA-N (2-chloro-3-methoxyphenyl)-[(1R,8S)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@H]1CCC2 ZIYVWOCHDPPRQB-QFBILLFUSA-N 0.000 claims 1
• UYIUAUOTIIXXKS-KNQAVFIVSA-N (2-chloroquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=NC2=CC=C(C=C2C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 UYIUAUOTIIXXKS-KNQAVFIVSA-N 0.000 claims 1
• TTYTYEPMUUULHR-XCLFUZPHSA-N (2-fluoro-4-methoxyphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=CC(=C1)OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TTYTYEPMUUULHR-XCLFUZPHSA-N 0.000 claims 1
• AEBPYHPPZHLPJY-VLIAUNLRSA-N (2-fluoro-4-methylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=CC(=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AEBPYHPPZHLPJY-VLIAUNLRSA-N 0.000 claims 1
• RXKCPUIGFQDHLL-ZHRRBRCNSA-N (2-imidazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RXKCPUIGFQDHLL-ZHRRBRCNSA-N 0.000 claims 1
• AHFXOBXKMMUQFY-VLIAUNLRSA-N (2-methylindazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C2C=CC=CC2=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AHFXOBXKMMUQFY-VLIAUNLRSA-N 0.000 claims 1
• WTWXHNLCGACQHJ-OFNKIYASSA-N (3-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C=NC2=CC=C(C=C2C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 WTWXHNLCGACQHJ-OFNKIYASSA-N 0.000 claims 1
• YNZSLNYIBIKCMQ-DIFFPNOSSA-N (3-chloro-5-fluoropyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=NC=C(C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F YNZSLNYIBIKCMQ-DIFFPNOSSA-N 0.000 claims 1
• LYVXQMJKAGWYOQ-QRWLVFNGSA-N (3-chloro-5-methoxyphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=C(C=C(C=1)OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 LYVXQMJKAGWYOQ-QRWLVFNGSA-N 0.000 claims 1
• VYXXLGQUZRBVAO-KUHUBIRLSA-N (3-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C VYXXLGQUZRBVAO-KUHUBIRLSA-N 0.000 claims 1
• WTVJKYYXGHSAQJ-WBMJQRKESA-N (3-fluoro-1,5-dimethylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=NN(C(=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C)C WTVJKYYXGHSAQJ-WBMJQRKESA-N 0.000 claims 1
• LVIGGIBAJSAOPT-VGSWGCGISA-N (3-fluoro-5-pyrazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=C(C=1)N1N=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 LVIGGIBAJSAOPT-VGSWGCGISA-N 0.000 claims 1
• MDFFCSOQJKECLA-PXAZEXFGSA-N (3-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C MDFFCSOQJKECLA-PXAZEXFGSA-N 0.000 claims 1
• AYTVIBWMKNIZOS-IERDGZPVSA-N (3-methyl-5-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)(C)C1=NC=2N(C(=C1)C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC(=C(C(=C4)F)F)F)C)[C@@H]1CCC3)N=CC=2C AYTVIBWMKNIZOS-IERDGZPVSA-N 0.000 claims 1
• APEKZRRGJPOOTR-ACJLOTCBSA-N (4-chloro-2-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C(=NC=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 APEKZRRGJPOOTR-ACJLOTCBSA-N 0.000 claims 1
• YNAYEVBYYNJYNJ-ACJLOTCBSA-N (4-chloro-5-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=NC=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YNAYEVBYYNJYNJ-ACJLOTCBSA-N 0.000 claims 1
• CCXYIPREYDZNPJ-YJYMSZOUSA-N (4-fluoropyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=2N(C=CC=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 CCXYIPREYDZNPJ-YJYMSZOUSA-N 0.000 claims 1
• IYMMEIPWFRVFNU-QRWLVFNGSA-N (4-methoxy-5-pyrazol-1-ylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NC=C1N1N=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 IYMMEIPWFRVFNU-QRWLVFNGSA-N 0.000 claims 1
• NEJLNCPINLSJBO-KUHUBIRLSA-N (4-methoxypyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=2N(C=CC=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 NEJLNCPINLSJBO-KUHUBIRLSA-N 0.000 claims 1
• UXZLLJSREZAKHR-YJYMSZOUSA-N (4-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UXZLLJSREZAKHR-YJYMSZOUSA-N 0.000 claims 1
• RIWYFBUYMNNACH-ACJLOTCBSA-N (4-methoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RIWYFBUYMNNACH-ACJLOTCBSA-N 0.000 claims 1
• ZCSHXPNCIRZDQN-ACJLOTCBSA-N (5,6-dimethoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=NC=1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 ZCSHXPNCIRZDQN-ACJLOTCBSA-N 0.000 claims 1
• KWSYXNMWCMBCEU-KDOFPFPSSA-N (5,6-dimethoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=C(C=NC=1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KWSYXNMWCMBCEU-KDOFPFPSSA-N 0.000 claims 1
• CDKPMNQGLHHMTG-XLIONFOSSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-5-(3,5-dichlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)Cl)Cl)C)[C@@H]1CCC2 CDKPMNQGLHHMTG-XLIONFOSSA-N 0.000 claims 1
• BBHNQOMBKUQJJV-YJYMSZOUSA-N (5-ethyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BBHNQOMBKUQJJV-YJYMSZOUSA-N 0.000 claims 1
• IPMJMGUBODZWRM-UTKZUKDTSA-N (5-ethyl-1-phenyl-1,2,4-triazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)C1=NC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 IPMJMGUBODZWRM-UTKZUKDTSA-N 0.000 claims 1
• UQCMUCZOOFDMGE-ZHRRBRCNSA-N (5-fluoro-2-pyrazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=C1 UQCMUCZOOFDMGE-ZHRRBRCNSA-N 0.000 claims 1
• GNBSGWXOHPVJKB-PXAZEXFGSA-N (5-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GNBSGWXOHPVJKB-PXAZEXFGSA-N 0.000 claims 1
• FBACIAVAIHWSAM-UZLBHIALSA-N (5-methoxy-1-phenyl-1,2,4-triazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=NC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 FBACIAVAIHWSAM-UZLBHIALSA-N 0.000 claims 1
• KVIRCWNPBNGNGJ-KUHUBIRLSA-N (5-methoxy-4-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C KVIRCWNPBNGNGJ-KUHUBIRLSA-N 0.000 claims 1
• MNHDNBUQUVXVNE-YJYMSZOUSA-N (5-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MNHDNBUQUVXVNE-YJYMSZOUSA-N 0.000 claims 1
• BRGULWTXWYMWDG-ZHRRBRCNSA-N (6-cyclopropyl-2-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=CC=C(C(=N1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BRGULWTXWYMWDG-ZHRRBRCNSA-N 0.000 claims 1
• GOPCRFISLSUSLN-VLIAUNLRSA-N (6-fluoropyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC=2N(C=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GOPCRFISLSUSLN-VLIAUNLRSA-N 0.000 claims 1
• AUAXYJJIFZPFBV-UZLBHIALSA-N (6-imidazol-1-ylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AUAXYJJIFZPFBV-UZLBHIALSA-N 0.000 claims 1
• SPPWHSGBNMUREF-BEFAXECRSA-N (6-methoxy-5-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C SPPWHSGBNMUREF-BEFAXECRSA-N 0.000 claims 1
• HHLUQRDNNRCZML-SZNDQCEHSA-N (6-methoxypyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC=2N(C=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HHLUQRDNNRCZML-SZNDQCEHSA-N 0.000 claims 1
• FACWDLUVSKSTMT-ACJLOTCBSA-N (6-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC=CC(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 FACWDLUVSKSTMT-ACJLOTCBSA-N 0.000 claims 1
• HLTTZNDUNMRTGX-KDOFPFPSSA-N (6-methoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HLTTZNDUNMRTGX-KDOFPFPSSA-N 0.000 claims 1
• DPEXPEWNJXENAW-PXAZEXFGSA-N (6-methoxypyrimidin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NC=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DPEXPEWNJXENAW-PXAZEXFGSA-N 0.000 claims 1
• BSMWQTHOKXWRNJ-IERDGZPVSA-N (6-methyl-3-pyrazol-1-ylpyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC=C(C(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=C1 BSMWQTHOKXWRNJ-IERDGZPVSA-N 0.000 claims 1
• STNGODDQHJMZKH-KDOFPFPSSA-N (7-chloroimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=CC=2N(C=C1)C(=CN=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 STNGODDQHJMZKH-KDOFPFPSSA-N 0.000 claims 1
• HWMBLPHBACRLRY-IERDGZPVSA-N (7-cyclopropyl-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=CC(=NC=2N1N=C(C=2)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HWMBLPHBACRLRY-IERDGZPVSA-N 0.000 claims 1
• KKCXYGXHUCNMDA-KDOFPFPSSA-N (7-fluoroimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC=2N(C=C1)C(=CN=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KKCXYGXHUCNMDA-KDOFPFPSSA-N 0.000 claims 1
• GXZPFNAOVAMOBW-KNQAVFIVSA-N (8-aminoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1C=C(C=C2C=CC=NC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 GXZPFNAOVAMOBW-KNQAVFIVSA-N 0.000 claims 1
• NHBIFYVPGJZXQW-KNQAVFIVSA-N (8-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C=C(C=C2C=CC=NC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 NHBIFYVPGJZXQW-KNQAVFIVSA-N 0.000 claims 1
• IDBMXXDFJWXYMN-UZLBHIALSA-N 1-[5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridin-2-yl]cyclopropane-1-carbonitrile Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=CC(=NC=1)C1(CC1)C#N IDBMXXDFJWXYMN-UZLBHIALSA-N 0.000 claims 1
• BZFYTDHYKDCYCD-IERDGZPVSA-N 1-[5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridin-3-yl]pyrrolidin-2-one Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C(C=NC=1)N1C(CCC1)=O BZFYTDHYKDCYCD-IERDGZPVSA-N 0.000 claims 1
• MBZFOWYEVPOOKN-QRWLVFNGSA-N 3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound O1CCCC2=NC=C(C=C21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MBZFOWYEVPOOKN-QRWLVFNGSA-N 0.000 claims 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
• TVRMGWPIAASKEM-ACJLOTCBSA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=C(C=C2OCCCN21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TVRMGWPIAASKEM-ACJLOTCBSA-N 0.000 claims 1
• BQZGDDFKISDIAH-ACJLOTCBSA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=CC(=C2OCCCN21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BQZGDDFKISDIAH-ACJLOTCBSA-N 0.000 claims 1
• GPGPAAGDFXXDND-KUHUBIRLSA-N 6-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridine-2-carbonitrile Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C1=CC=CC(=N1)C#N GPGPAAGDFXXDND-KUHUBIRLSA-N 0.000 claims 1
• AKIOQQVCDGVFQN-YKSBVNFPSA-N 6-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-1-(2-fluoroethyl)quinolin-4-one Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C(C=CN(C2=CC=1)CCF)=O AKIOQQVCDGVFQN-YKSBVNFPSA-N 0.000 claims 1
• OMMGAXVUOQTYRZ-QUCCMNQESA-N 6-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-4-methyl-1,4-benzoxazin-3-one Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=CC2=C(OCC(N2C)=O)C=C1 OMMGAXVUOQTYRZ-QUCCMNQESA-N 0.000 claims 1
• DCXBIZUASUMXQQ-VGSWGCGISA-N N-[3-methoxy-5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]phenyl]acetamide Chemical compound COC=1C=C(C=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)NC(C)=O DCXBIZUASUMXQQ-VGSWGCGISA-N 0.000 claims 1
• HGDHJSATEJUOLI-UZLBHIALSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(2-pyrazol-1-ylpyridin-4-yl)methanone Chemical compound N1(N=CC=C1)C1=NC=CC(=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HGDHJSATEJUOLI-UZLBHIALSA-N 0.000 claims 1
• WEANNUCJQVYULB-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(4-pyrazol-1-ylpyridin-2-yl)methanone Chemical compound N1(N=CC=C1)C1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WEANNUCJQVYULB-IERDGZPVSA-N 0.000 claims 1
• KDMXKJBNBZMCBN-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(4-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C1=C(C=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KDMXKJBNBZMCBN-VFNWGFHPSA-N 0.000 claims 1
• DWZCHFFRTPZKOH-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-propan-2-yloxypyridin-3-yl)methanone Chemical compound C(C)(C)OC=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DWZCHFFRTPZKOH-IERDGZPVSA-N 0.000 claims 1
• AUIQQRPQYBVUAW-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AUIQQRPQYBVUAW-IERDGZPVSA-N 0.000 claims 1
• XXSIWIALDYQTQO-VLIAUNLRSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-propan-2-ylpyrimidin-4-yl)methanone Chemical compound C(C)(C)C1=CC(=NC=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XXSIWIALDYQTQO-VLIAUNLRSA-N 0.000 claims 1
• BHUYGBCUWIPUOY-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrazol-1-ylpyridin-2-yl)methanone Chemical compound N1(N=CC=C1)C1=CC=CC(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BHUYGBCUWIPUOY-QRWLVFNGSA-N 0.000 claims 1
• UGYVPNGSRATLKA-UZLBHIALSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UGYVPNGSRATLKA-UZLBHIALSA-N 0.000 claims 1
• OASYIQAYBFOKDP-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrrol-1-ylpyridin-3-yl)methanone Chemical compound N1(C=CC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OASYIQAYBFOKDP-UTKZUKDTSA-N 0.000 claims 1
• YYWCUXGWJAGEIJ-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[1,5-a]pyridin-7-yl)methanone Chemical compound N=1C=NN2C=1C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YYWCUXGWJAGEIJ-KDOFPFPSSA-N 0.000 claims 1
• BAZKUEQYIZPOIS-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[4,3-a]pyridin-7-yl)methanone Chemical compound N=1N=CN2C=1C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BAZKUEQYIZPOIS-KDOFPFPSSA-N 0.000 claims 1
• MRNRBXURUVCVOW-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=C(C=C(C=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MRNRBXURUVCVOW-VFNWGFHPSA-N 0.000 claims 1
• NLQNNVNESZKTPT-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 NLQNNVNESZKTPT-VFNWGFHPSA-N 0.000 claims 1
• WZIFKSFXBMKMPH-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-1-yl)phenyl]methanone Chemical compound N1(N=NC=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WZIFKSFXBMKMPH-VFNWGFHPSA-N 0.000 claims 1
• XKDKCEDYXTXVOP-VLIAUNLRSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-3-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XKDKCEDYXTXVOP-VLIAUNLRSA-N 0.000 claims 1
• QXEGWMZTYWEQFY-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-4-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC(=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 QXEGWMZTYWEQFY-QRWLVFNGSA-N 0.000 claims 1
• PJCQKNJCMGYSGN-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=C(C=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 PJCQKNJCMGYSGN-VFNWGFHPSA-N 0.000 claims 1
• TWNOKRKAONVJLC-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TWNOKRKAONVJLC-VFNWGFHPSA-N 0.000 claims 1
• PHTFSKSFIYBJBN-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 PHTFSKSFIYBJBN-UTKZUKDTSA-N 0.000 claims 1
• XSKZYWKJCGZPCL-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XSKZYWKJCGZPCL-IERDGZPVSA-N 0.000 claims 1
• MRVZBRAIYIPGHU-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(triazol-2-yl)pyridin-2-yl]methanone Chemical compound N=1N(N=CC=1)C=1C(=NC=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MRVZBRAIYIPGHU-KDOFPFPSSA-N 0.000 claims 1
• YAGVMJYDXFQQNS-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-4-yl)pyridin-2-yl]methanone Chemical compound N=1N=CN(C=1)C1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YAGVMJYDXFQQNS-QRWLVFNGSA-N 0.000 claims 1
• HWLKHBGZSPQVCJ-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[5-(1,2,4-triazol-4-yl)pyridin-3-yl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HWLKHBGZSPQVCJ-QRWLVFNGSA-N 0.000 claims 1
• ZEJWYIRSDCXJOC-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[5-(triazol-2-yl)pyridin-3-yl]methanone Chemical compound N=1N(N=CC=1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 ZEJWYIRSDCXJOC-QRWLVFNGSA-N 0.000 claims 1
• IWBMKXVHKSBTPS-APWZRJJASA-N [(1S,8R)-4-methyl-5-[5-(trifluoromethyl)thiophen-2-yl]-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C=1SC(=CC=1)C(F)(F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 IWBMKXVHKSBTPS-APWZRJJASA-N 0.000 claims 1
• HQWCVNCKTOJMIR-KNQAVFIVSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinazolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=NC=NC2=CC=1 HQWCVNCKTOJMIR-KNQAVFIVSA-N 0.000 claims 1
• NGTUNMOWIRHVDP-OFNKIYASSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 NGTUNMOWIRHVDP-OFNKIYASSA-N 0.000 claims 1
• AQEYEVXVCDXQJV-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-5-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=C2N=CC=NC2=CC=C1 AQEYEVXVCDXQJV-UTKZUKDTSA-N 0.000 claims 1
• FCVJXRXVWWAENR-GCJKJVERSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2N=CC=NC2=CC=1 FCVJXRXVWWAENR-GCJKJVERSA-N 0.000 claims 1
• OBXQIVVIJCBYFA-ZHRRBRCNSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C=C3)F)F)C)[C@@H]1CCC2 OBXQIVVIJCBYFA-ZHRRBRCNSA-N 0.000 claims 1
• YZGXBUQGMROJOV-JPYJTQIMSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 YZGXBUQGMROJOV-JPYJTQIMSA-N 0.000 claims 1
• WMRFKCKRLJSOIJ-ZHRRBRCNSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2N=CC=NC2=CC=1 WMRFKCKRLJSOIJ-ZHRRBRCNSA-N 0.000 claims 1
• BZRJOSCAOZJAHY-IRLDBZIGSA-N [(1S,8R)-5-(3,5-dichlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)Cl)Cl)C)[C@@H]1CCC2 BZRJOSCAOZJAHY-IRLDBZIGSA-N 0.000 claims 1
• ABQRWYYEZAJLCK-OFNKIYASSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-oxidoquinolin-1-ium-6-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=[N+](C2=CC=1)[O-] ABQRWYYEZAJLCK-OFNKIYASSA-N 0.000 claims 1
• DYHSEBDUEXPEPD-XXBNENTESA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(2-pyrimidin-2-ylphenyl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=C(C=CC=C1)C1=NC=CC=N1 DYHSEBDUEXPEPD-XXBNENTESA-N 0.000 claims 1
• LRPFHSBMTDVKSD-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-ethyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)CC)C1=CC=CC=C1 LRPFHSBMTDVKSD-IRLDBZIGSA-N 0.000 claims 1
• JLMIZUIXBMPXOO-QAPCUYQASA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-methoxy-1-methylpyrazol-4-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=NN(C=1OC)C JLMIZUIXBMPXOO-QAPCUYQASA-N 0.000 claims 1
• SFQDPXIUOFLESM-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-methyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)C)C1=CC=CC=C1 SFQDPXIUOFLESM-IRLDBZIGSA-N 0.000 claims 1
• BAYCHQXMTBCYGZ-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)C)C1=CC=C(C=C1)F BAYCHQXMTBCYGZ-IRLDBZIGSA-N 0.000 claims 1
• JJCVDVSZKLITPX-QAPCUYQASA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-ethyl-5-(trifluoromethyl)pyrazol-3-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=C1)C(F)(F)F)CC JJCVDVSZKLITPX-QAPCUYQASA-N 0.000 claims 1
• PUMUSGNPLSGQMY-OFNKIYASSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 PUMUSGNPLSGQMY-OFNKIYASSA-N 0.000 claims 1
• NHNCPYZDAMDSIT-VGSWGCGISA-N [(1S,8R)-5-(3-chloro-4-methoxyphenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C=C3)OC)Cl)C)[C@@H]1CCC2 NHNCPYZDAMDSIT-VGSWGCGISA-N 0.000 claims 1
• PNEKPBPWWFWLSJ-JPYJTQIMSA-N [(1S,8R)-5-[3-(difluoromethyl)-4-fluorophenyl]-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC(C=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1)F PNEKPBPWWFWLSJ-JPYJTQIMSA-N 0.000 claims 1
• NTDUJOKVIDTUFW-ZHRRBRCNSA-N [(1S,8R)-5-[3-(difluoromethyl)-4-fluorophenyl]-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound FC(C=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2N=CC=NC2=CC=1)F NTDUJOKVIDTUFW-ZHRRBRCNSA-N 0.000 claims 1
• XPKYEGDQLHBJPD-QRWLVFNGSA-N [1-(2-methoxyphenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=CC=C1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XPKYEGDQLHBJPD-QRWLVFNGSA-N 0.000 claims 1
• OAPNJFZJQWEPOA-UZLBHIALSA-N [1-(3-fluorophenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OAPNJFZJQWEPOA-UZLBHIALSA-N 0.000 claims 1
• UXTNOTGXPQVVON-IERDGZPVSA-N [1-(3-methoxyphenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UXTNOTGXPQVVON-IERDGZPVSA-N 0.000 claims 1
• YFLJTQLASQZXJD-UTKZUKDTSA-N [1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC=C(C=C1)N1N=C(N=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YFLJTQLASQZXJD-UTKZUKDTSA-N 0.000 claims 1
• HBQVCCALVGCLRW-ACJLOTCBSA-N [1-tert-butyl-5-(trifluoromethyl)pyrazol-4-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)(C)(C)N1N=CC(=C1C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HBQVCCALVGCLRW-ACJLOTCBSA-N 0.000 claims 1
• SMUJAXFFFBWAGB-ZHRRBRCNSA-N [2-(4-methyltriazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=NN(N=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 SMUJAXFFFBWAGB-ZHRRBRCNSA-N 0.000 claims 1
• BJMKJAUWMFZXMB-DYVFJYSZSA-N [2-(difluoromethyl)imidazo[1,2-a]pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC(C=1N=C2N(C=CC=C2)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F BJMKJAUWMFZXMB-DYVFJYSZSA-N 0.000 claims 1
• QLRHHXHYQKNZPK-XXBNENTESA-N [3-(1-methylpyrazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC(=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 QLRHHXHYQKNZPK-XXBNENTESA-N 0.000 claims 1
• WKBUTNQMYFYMIP-GCJKJVERSA-N [3-(4-fluoropyrazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=NN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WKBUTNQMYFYMIP-GCJKJVERSA-N 0.000 claims 1
• GFLTUKCQSILKKZ-JPYJTQIMSA-N [3-(4-methoxypyrazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=NN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GFLTUKCQSILKKZ-JPYJTQIMSA-N 0.000 claims 1
• DTTKPYHUDABKDU-VLIAUNLRSA-N [3-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 DTTKPYHUDABKDU-VLIAUNLRSA-N 0.000 claims 1
• IEKUSQDQFFMKNX-VLIAUNLRSA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 IEKUSQDQFFMKNX-VLIAUNLRSA-N 0.000 claims 1
• RYVHLCZBIVILJL-IERDGZPVSA-N [3-fluoro-5-(1,2,4-triazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=C(C=1)N1C=NN=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RYVHLCZBIVILJL-IERDGZPVSA-N 0.000 claims 1
• VLTSBNJWZWWQDD-QRWLVFNGSA-N [3-methoxy-2-(triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=NC=C1 VLTSBNJWZWWQDD-QRWLVFNGSA-N 0.000 claims 1
• UCHBKKSHFMPYMC-QRWLVFNGSA-N [3-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 UCHBKKSHFMPYMC-QRWLVFNGSA-N 0.000 claims 1
• ILGCAPJQUOFKIK-IERDGZPVSA-N [3-methyl-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 ILGCAPJQUOFKIK-IERDGZPVSA-N 0.000 claims 1
• NKJZSRRTCWOSNM-QRWLVFNGSA-N [4-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 NKJZSRRTCWOSNM-QRWLVFNGSA-N 0.000 claims 1
• SQGVYFNSRZTARU-QRWLVFNGSA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 SQGVYFNSRZTARU-QRWLVFNGSA-N 0.000 claims 1
• RCAGAILWWRIITL-QRWLVFNGSA-N [4-fluoro-3-(1,2,4-triazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1C=NN=C1 RCAGAILWWRIITL-QRWLVFNGSA-N 0.000 claims 1
• NQLOFXQHDPWBDZ-IERDGZPVSA-N [4-methyl-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 NQLOFXQHDPWBDZ-IERDGZPVSA-N 0.000 claims 1
• NWMRUPWIFRKUPF-BZNIZROVSA-N [5-(difluoromethyl)-1-methylpyrazol-4-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC(C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F NWMRUPWIFRKUPF-BZNIZROVSA-N 0.000 claims 1
• ZEDUXVVSVQPKCY-BWKNWUBXSA-N [5-cyclopropyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C1=CC(=CC=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 ZEDUXVVSVQPKCY-BWKNWUBXSA-N 0.000 claims 1
• KIYFMEBGRDOBMX-VFNWGFHPSA-N [5-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 KIYFMEBGRDOBMX-VFNWGFHPSA-N 0.000 claims 1
• STJVWUYZONMQCK-QRQCRPRQSA-N [5-methoxy-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 STJVWUYZONMQCK-QRQCRPRQSA-N 0.000 claims 1
• IOECBWNHQRIVDY-QRQCRPRQSA-N [5-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 IOECBWNHQRIVDY-QRQCRPRQSA-N 0.000 claims 1
• GLDOYCATHXYWPZ-ZHRRBRCNSA-N [5-methyl-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 GLDOYCATHXYWPZ-ZHRRBRCNSA-N 0.000 claims 1
• OCMAOQYMABIBSW-ZHRRBRCNSA-N [5-methyl-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 OCMAOQYMABIBSW-ZHRRBRCNSA-N 0.000 claims 1
• ZOOIBWVMJIQEFP-BEFAXECRSA-N [6-(dimethylamino)pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN(C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C ZOOIBWVMJIQEFP-BEFAXECRSA-N 0.000 claims 1
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• JZBSYAWPULCYNA-BEFAXECRSA-N [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC=C(C(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 JZBSYAWPULCYNA-BEFAXECRSA-N 0.000 claims 1
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