JP7407513B2 - 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態 - Google Patents

生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態 Download PDF

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JP7407513B2
JP7407513B2 JP2018555127A JP2018555127A JP7407513B2 JP 7407513 B2 JP7407513 B2 JP 7407513B2 JP 2018555127 A JP2018555127 A JP 2018555127A JP 2018555127 A JP2018555127 A JP 2018555127A JP 7407513 B2 JP7407513 B2 JP 7407513B2
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ambrox
bioconversion
homofarnesol
medium
mixture
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JP2019521952A (ja
JP2019521952A5 (enExample
JPWO2017182542A5 (enExample
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サンハージ,ジスラン
ルソー,アリックス
ノエル,サンドリーヌ
アイクホーン,エリック
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ジボダン エス エー
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Priority claimed from PCT/EP2016/058997 external-priority patent/WO2016170106A1/en
Priority claimed from PCT/EP2016/058987 external-priority patent/WO2016170099A1/en
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Priority to JP2023138844A priority patent/JP7723048B2/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00Formulations or additives for perfume preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y504/00Intramolecular transferases (5.4)
    • C12Y504/99Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017Squalene--hopene cyclase (5.4.99.17)

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
JP2018555127A 2016-04-22 2017-04-20 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態 Active JP7407513B2 (ja)

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JP2021205922A JP7343564B2 (ja) 2016-04-22 2021-12-20 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態
JP2023138844A JP7723048B2 (ja) 2016-04-22 2023-08-29 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EPPCT/EP2016/058987 2016-04-22
EPPCT/EP2016/058997 2016-04-22
PCT/EP2016/058997 WO2016170106A1 (en) 2015-04-24 2016-04-22 Process for isolating and purifying ambrox
PCT/EP2016/058987 WO2016170099A1 (en) 2015-04-24 2016-04-22 Enzymes and applications thereof
GBGB1618090.3A GB201618090D0 (en) 2016-10-26 2016-10-26 Product
GB1618090.3 2016-10-26
PCT/EP2017/059327 WO2017182542A1 (en) 2016-04-22 2017-04-20 A solid form of (-)-ambrox formed by a bioverversion of homofarnesol in the presence of a biocatalyst

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JP2021205922A Division JP7343564B2 (ja) 2016-04-22 2021-12-20 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態
JP2023138844A Division JP7723048B2 (ja) 2016-04-22 2023-08-29 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態

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JP2019521952A JP2019521952A (ja) 2019-08-08
JP2019521952A5 JP2019521952A5 (enExample) 2020-05-28
JPWO2017182542A5 JPWO2017182542A5 (enExample) 2023-11-21
JP7407513B2 true JP7407513B2 (ja) 2024-01-04

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JP2018555127A Active JP7407513B2 (ja) 2016-04-22 2017-04-20 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態
JP2021205922A Active JP7343564B2 (ja) 2016-04-22 2021-12-20 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態
JP2023138844A Active JP7723048B2 (ja) 2016-04-22 2023-08-29 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態

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JP2023138844A Active JP7723048B2 (ja) 2016-04-22 2023-08-29 生体触媒の存在下におけるホモファルネソールの生物変換によって形成された(-)-アンブロックス(Ambrox)の固体形態

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US (5) US10844412B2 (enExample)
EP (1) EP3445755A1 (enExample)
JP (3) JP7407513B2 (enExample)
CN (2) CN115819385B (enExample)
BR (1) BR112018071284A2 (enExample)
CO (1) CO2018011292A2 (enExample)
GB (1) GB201618090D0 (enExample)
IL (5) IL290606B2 (enExample)
MX (2) MX2018012836A (enExample)
RU (1) RU2018136063A (enExample)
SG (1) SG11201808643SA (enExample)
WO (1) WO2017182542A1 (enExample)

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GB201618090D0 (en) 2016-10-26 2016-12-07 Givaudan Sa Product
GB201917688D0 (en) * 2019-12-04 2020-01-15 Givaudan Sa SHC enzymes and enzyme variants
GB201917694D0 (en) 2019-12-04 2020-01-15 Givaudan Sa Enzyme mediated process
GB202011823D0 (en) 2020-07-30 2020-09-16 Givaudan Sa Method
GB202020331D0 (en) * 2020-12-22 2021-02-03 Givaudan Sa Process of making organic compounds
MX2024011115A (es) 2022-03-17 2024-09-18 Givaudan Sa Enzimas escualeno-hopeno-ciclasa (shc) y variantes de enzimas.
WO2024097746A1 (en) * 2022-11-01 2024-05-10 Conagen Inc. Alkene cyclopropanation with nickel catalyst enhancer and improved rearrangement reaction

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US20210040521A1 (en) 2021-02-11
JP2019521952A (ja) 2019-08-08
JP2022061977A (ja) 2022-04-19
GB201618090D0 (en) 2016-12-07
CO2018011292A2 (es) 2018-11-13
US20240401094A1 (en) 2024-12-05
IL304330A (en) 2023-09-01
IL310388B1 (en) 2025-06-01
US20230357809A1 (en) 2023-11-09
SG11201808643SA (en) 2018-11-29
IL310388A (en) 2024-03-01
US20190136275A1 (en) 2019-05-09
CN115819385B (zh) 2025-05-13
WO2017182542A1 (en) 2017-10-26
IL290606A (en) 2022-04-01
CN109071480B (zh) 2022-11-29
MX2018012836A (es) 2019-03-11
IL304330B1 (en) 2024-03-01
US11773419B2 (en) 2023-10-03
US11401541B2 (en) 2022-08-02
IL290606B2 (en) 2024-02-01
IL262393A (en) 2018-12-31
IL304330B2 (en) 2024-07-01
IL310388B2 (en) 2025-10-01
CN109071480A (zh) 2018-12-21
IL290606B1 (en) 2023-10-01
IL320763A (en) 2025-07-01
MX2023014907A (es) 2024-02-15
BR112018071284A2 (pt) 2019-02-12
EP3445755A1 (en) 2019-02-27
JP2023179438A (ja) 2023-12-19
US12084699B2 (en) 2024-09-10
JP7343564B2 (ja) 2023-09-12
JP7723048B2 (ja) 2025-08-13
CN115819385A (zh) 2023-03-21
IL262393B (en) 2022-03-01
US20220177935A1 (en) 2022-06-09
US10844412B2 (en) 2020-11-24
RU2018136063A (ru) 2020-05-22
RU2018136063A3 (enExample) 2020-07-13

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