JP7401432B2 - 操作されたｄｎａ結合タンパク質 - Google Patents

操作されたｄｎａ結合タンパク質 Download PDF

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JP7401432B2
JP7401432B2 JP2020529582A JP2020529582A JP7401432B2 JP 7401432 B2 JP7401432 B2 JP 7401432B2 JP 2020529582 A JP2020529582 A JP 2020529582A JP 2020529582 A JP2020529582 A JP 2020529582A JP 7401432 B2 JP7401432 B2 JP 7401432B2
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seq
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etf
certain embodiments
expression
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JP2021505133A (ja
JP2021505133A5 (enExample
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ステファニー タグリアテラ，
アン タネンハウス，
カルティク ラマモールティ，
アンドリュー ヤング，
デイビッド オーバーコフラー，
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エンコーデッド セラピューティクス， インコーポレイテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region

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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2020529582A 2017-12-01 2018-11-30 操作されたｄｎａ結合タンパク質 Active JP7401432B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022145839A JP7634507B2 (ja) 2017-12-01 2022-09-14 操作されたｄｎａ結合タンパク質
JP2024043454A JP2024069591A (ja) 2017-12-01 2024-03-19 操作されたｄｎａ結合タンパク質

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201762593824P 2017-12-01 2017-12-01
US62/593,824 2017-12-01
US201762610014P 2017-12-22 2017-12-22
US62/610,014 2017-12-22
US201862618966P 2018-01-18 2018-01-18
US62/618,966 2018-01-18
US201862641806P 2018-03-12 2018-03-12
US62/641,806 2018-03-12
US201862646198P 2018-03-21 2018-03-21
US62/646,198 2018-03-21
US201862664814P 2018-04-30 2018-04-30
US201862664817P 2018-04-30 2018-04-30
US62/664,814 2018-04-30
US62/664,817 2018-04-30
PCT/US2018/063498 WO2019109051A1 (en) 2017-12-01 2018-11-30 Engineered dna binding proteins

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JP2021505133A JP2021505133A (ja) 2021-02-18
JP2021505133A5 JP2021505133A5 (enExample) 2022-01-11
JP7401432B2 true JP7401432B2 (ja) 2023-12-19

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JP2022145839A Active JP7634507B2 (ja) 2017-12-01 2022-09-14 操作されたｄｎａ結合タンパク質
JP2024043454A Pending JP2024069591A (ja) 2017-12-01 2024-03-19 操作されたｄｎａ結合タンパク質

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JP2024043454A Pending JP2024069591A (ja) 2017-12-01 2024-03-19 操作されたｄｎａ結合タンパク質

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US (2) US12083188B2 (enExample)
EP (1) EP3717505A4 (enExample)
JP (3) JP7401432B2 (enExample)
KR (1) KR20200107949A (enExample)
CN (2) CN111727259B (enExample)
AU (2) AU2018375192B2 (enExample)
BR (1) BR112020010883A2 (enExample)
CA (1) CA3083765A1 (enExample)
CL (1) CL2020001451A1 (enExample)
IL (2) IL274926B1 (enExample)
MA (1) MA50942A (enExample)
MX (1) MX2020005561A (enExample)
SG (1) SG11202004926WA (enExample)
TW (3) TWI835761B (enExample)
WO (1) WO2019109051A1 (enExample)

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US20240024372A1 (en) * 2020-12-09 2024-01-25 City Of Hope Compounds and methods to treat cystic fibrosis
CN115074389A (zh) * 2022-06-13 2022-09-20 华南农业大学 稳定表达鸭坦布苏病毒ns1蛋白的细胞系的构建方法及其应用
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