EP2021499A4 - Functional arrays for high throughput characterization of gene expression regulatory elements - Google Patents
Functional arrays for high throughput characterization of gene expression regulatory elementsInfo
- Publication number
- EP2021499A4 EP2021499A4 EP06849046A EP06849046A EP2021499A4 EP 2021499 A4 EP2021499 A4 EP 2021499A4 EP 06849046 A EP06849046 A EP 06849046A EP 06849046 A EP06849046 A EP 06849046A EP 2021499 A4 EP2021499 A4 EP 2021499A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gene expression
- high throughput
- regulatory elements
- expression regulatory
- throughput characterization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75092905P | 2005-12-16 | 2005-12-16 | |
US76205606P | 2006-01-24 | 2006-01-24 | |
US11/636,385 US20070161031A1 (en) | 2005-12-16 | 2006-12-07 | Functional arrays for high throughput characterization of gene expression regulatory elements |
PCT/US2006/046920 WO2007078599A2 (en) | 2005-12-16 | 2006-12-08 | Functional arrays for high throughput characterization of gene expression regulatory elements |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2021499A2 EP2021499A2 (en) | 2009-02-11 |
EP2021499A4 true EP2021499A4 (en) | 2010-02-17 |
Family
ID=38228711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06849046A Ceased EP2021499A4 (en) | 2005-12-16 | 2006-12-08 | Functional arrays for high throughput characterization of gene expression regulatory elements |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2021499A4 (en) |
JP (1) | JP2009519710A (en) |
WO (1) | WO2007078599A2 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102575251B (en) | 2009-05-18 | 2018-12-04 | 库尔纳公司 | The relevant disease of the reprogramming factor is treated by inhibiting the natural antisense transcript for the reprogramming factor |
ES2707590T3 (en) | 2009-07-15 | 2019-04-04 | Zhenglun Zhu | Management of the treatment of inflammatory or autoimmune disorders using expression of Hom-1 |
ES2711256T3 (en) | 2010-04-23 | 2019-04-30 | Univ Florida | Compositions of rAAV-guanylate cyclase and methods to treat congenital amaurosis of Leber 1 (LCA1) |
WO2011146411A1 (en) * | 2010-05-17 | 2011-11-24 | University Of Southern California | Grp78 gene polymorphism rs391957 is associated with tumor recurrence and survival in gastrointestinal cancer patients |
DK2661494T3 (en) * | 2011-01-07 | 2019-09-02 | Applied Genetic Tech Corporation | Promoters, expression cassettes and vectors for use in the treatment of achromatopsia and other diseases |
JP6482869B2 (en) | 2012-04-03 | 2019-03-13 | 国立研究開発法人国立成育医療研究センター | DNA for controlling expression of miR-140 and method for screening drug using the DNA |
US9163259B2 (en) | 2012-05-04 | 2015-10-20 | Novartis Ag | Viral vectors for the treatment of retinal dystrophy |
WO2014031079A1 (en) * | 2012-08-21 | 2014-02-27 | Singapore Health Services Pte Ltd | Method and/or probe for determining glaucoma susceptibility |
KR102270068B1 (en) | 2013-03-14 | 2021-06-28 | 몬산토 테크놀로지 엘엘씨 | Plant regulatory elements and uses thereof |
US9701985B2 (en) | 2013-06-04 | 2017-07-11 | Virginia Commonwealth University | mda-9/syntenin promoter to image and treat metastatic cancer cells |
SG11201605906UA (en) | 2014-01-21 | 2016-08-30 | Univ Bruxelles | Muscle-specific nucleic acid regulatory elements and methods and use thereof |
US20150276767A1 (en) * | 2014-03-12 | 2015-10-01 | The University Of Sydney | Systems and methods for identifying cancers having activated progesterone receptors |
ES2843848T3 (en) * | 2014-03-21 | 2021-07-20 | Life Technologies Corp | Reference test for multiple copies |
CN103981185B (en) * | 2014-04-14 | 2016-04-27 | 浙江理工大学 | Liver cancer-specific GP73 core promoter and screening construction process thereof |
KR101791296B1 (en) * | 2014-04-17 | 2017-10-27 | 제주대학교 산학협력단 | Expression cassette and vector with genes related Alzheimer's disease and transgenic cell line made from it |
RU2017112748A (en) | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | ONAPRISTON COMPOSITIONS OF LONG-TERM ACTIONS AND METHODS |
CN104673797B (en) * | 2015-02-09 | 2018-02-02 | 苏州大学 | Participate in long-chain non-coding RNA and its application of human body cell ionising radiation stress reaction |
US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
WO2016200263A1 (en) * | 2015-06-12 | 2016-12-15 | Erasmus University Medical Center Rotterdam | New crispr assays |
WO2017053793A1 (en) | 2015-09-25 | 2017-03-30 | Arno Therapeutics, Inc. | Methods of making onapristone intermediates |
US10548905B2 (en) | 2015-12-15 | 2020-02-04 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
KR102450833B1 (en) | 2016-04-15 | 2022-10-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Gene therapy for the treatment of hemophilia A |
WO2018102369A1 (en) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
WO2018111104A1 (en) * | 2016-12-14 | 2018-06-21 | Erasmus University Medical Center Rotterdam | Use of human crispr sequences in diagnostics |
EP3600445A1 (en) | 2017-03-27 | 2020-02-05 | Vrije Universiteit Brussel | Diaphragm-specific nucleic acid regulatory elements and methods and use thereof |
TWI808079B (en) * | 2017-04-03 | 2023-07-11 | 美商編碼製藥公司 | Tissue selective transgene expression |
KR102625470B1 (en) | 2017-05-31 | 2024-01-16 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Optimized human coagulation factor IX gene expression cassette and use thereof |
RU2671156C1 (en) * | 2017-08-21 | 2018-10-29 | Общество с ограниченной ответственностью "Центр Генетики и Репродуктивной Медицины "ГЕНЕТИКО" | Method of preimplantation genetic diagnostics of type 1 spinal muscular atrophy |
JP7150018B2 (en) * | 2017-11-20 | 2022-10-07 | トゥルン イリオピスト | Novel CIP2A variants and uses thereof |
CN112996927A (en) * | 2018-10-31 | 2021-06-18 | 罗格斯新泽西州立大学 | GRAMC: method for determining genome-scale reporter of cis-regulatory module |
FR3088194B1 (en) * | 2018-11-09 | 2021-02-19 | Univ Paris Sud | USING THE MICRORNA MIR-27A-5P TO TREAT CLOSTRIDIUM DIFFICILE INTESTINAL INFLAMMATION |
US20220170110A1 (en) * | 2019-04-05 | 2022-06-02 | Korea Advanced Institute Of Science And Technology | Cancer diagnostic marker using transposase-accessible chromatin sequencing information about individual, and use thereof |
KR102192455B1 (en) * | 2019-04-05 | 2020-12-17 | 한국과학기술원 | A cancer diagnosis marker based on ATAC-Seq and Method using the same |
CN110117659B (en) * | 2019-06-18 | 2022-10-11 | 上海奕谱生物科技有限公司 | Novel tumor marker STAMP-EP10 and application thereof |
EP4153759A2 (en) * | 2020-05-19 | 2023-03-29 | Ixaka France | Promoter sequences for in vitro and in vivo expression of gene therapy products in cd3+ cells |
CA3163572A1 (en) | 2020-05-27 | 2021-12-02 | Oleksandr PASTUKHOV | Novel transduction enhancers and uses thereof |
BR112023006305A2 (en) * | 2020-10-09 | 2023-05-09 | Tenaya Therapeutics Inc | METHODS AND COMPOSITIONS OF GENE THERAPY WITH PLACOFILLIN-2 |
US11781156B2 (en) | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
WO2022212766A2 (en) * | 2021-03-31 | 2022-10-06 | Hunterian Medicine Llc | Compact promoters for gene expression |
CN113265428B (en) * | 2021-06-11 | 2023-03-14 | 东北林业大学 | Detection system for constructing copper change in living cells by utilizing metallothionein and application |
WO2023150553A1 (en) * | 2022-02-01 | 2023-08-10 | University Of Rochester | Gpr17 promoter-based targeting and transduction of glial progenitor cells |
WO2024001172A1 (en) * | 2022-06-27 | 2024-01-04 | Ractigen Therapeutics | Oligonucleotide modulators activating complement factor h expression |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6242211B1 (en) * | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US6504084B1 (en) * | 1999-04-23 | 2003-01-07 | Pioneer Hi-Bred International, Inc. | Maize NPR1 polynucleotides and methods of use |
US20030211481A1 (en) * | 2002-05-08 | 2003-11-13 | Erives Albert J. | Method for identifying cellular targets |
-
2006
- 2006-12-08 EP EP06849046A patent/EP2021499A4/en not_active Ceased
- 2006-12-08 JP JP2008545677A patent/JP2009519710A/en not_active Withdrawn
- 2006-12-08 WO PCT/US2006/046920 patent/WO2007078599A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Non-Patent Citations (6)
Title |
---|
COOPER SARA J ET AL: "Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.", GENOME RESEARCH JAN 2006, vol. 16, no. 1, 12 December 2005 (2005-12-12), pages 1 - 10, XP009126140, ISSN: 1088-9051 * |
ENCODE PROJECT CONSORTIUM: "The ENCODE (ENCyclopedia Of DNA Elements) Project.", SCIENCE (NEW YORK, N.Y.) 22 OCT 2004, vol. 306, no. 5696, 22 October 2004 (2004-10-22), pages 636 - 640, XP009126138, ISSN: 1095-9203 * |
KIM TAE HOON ET AL: "Direct isolation and identification of promoters in the human genome.", GENOME RESEARCH JUN 2005, vol. 15, no. 6, June 2005 (2005-06-01), pages 830 - 839, XP002412922, ISSN: 1088-9051 * |
TRINKLEIN NATHAN D ET AL: "An abundance of bidirectional promoters in the human genome.", GENOME RESEARCH, vol. 14, no. 1, January 2004 (2004-01-01), pages 62 - 66, XP009126141, ISSN: 1088-9051 * |
TRINKLEIN NATHAN D ET AL: "Identification and functional analysis of human transcriptional promoters.", GENOME RESEARCH FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 308 - 312, XP009126139, ISSN: 1088-9051 * |
WILSON V S ET AL: "A NOVEL CELL LINE, MDA-KB2, THAT STABLY EXPRESSES AN ANDROGEN- AND GLUCOCORTICOID-RESPONSIVE REPORTER FOR THE DETECTION OF HORMONE RECEPTOR AGONISTS AND ANTAGONISTS", TOXICOLOGICAL SCIENCES, ACADEMIC PRESS, SAN DIEGO, FL, US, vol. 66, no. 1, 1 March 2002 (2002-03-01), pages 69 - 81, XP009028294, ISSN: 1096-6080 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007078599A8 (en) | 2008-10-30 |
WO2007078599A2 (en) | 2007-07-12 |
EP2021499A2 (en) | 2009-02-11 |
WO2007078599A3 (en) | 2008-08-28 |
JP2009519710A (en) | 2009-05-21 |
WO2007078599A9 (en) | 2007-10-04 |
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Legal Events
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