EP2021499A4 - Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz - Google Patents

Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz

Info

Publication number
EP2021499A4
EP2021499A4 EP06849046A EP06849046A EP2021499A4 EP 2021499 A4 EP2021499 A4 EP 2021499A4 EP 06849046 A EP06849046 A EP 06849046A EP 06849046 A EP06849046 A EP 06849046A EP 2021499 A4 EP2021499 A4 EP 2021499A4
Authority
EP
European Patent Office
Prior art keywords
gene expression
high throughput
regulatory elements
expression regulatory
throughput characterization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06849046A
Other languages
English (en)
French (fr)
Other versions
EP2021499A2 (de
Inventor
Nathan D Trinklein
Shelley F Aldred
Sara J Cooper
Richard M Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/636,385 external-priority patent/US20070161031A1/en
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP2021499A2 publication Critical patent/EP2021499A2/de
Publication of EP2021499A4 publication Critical patent/EP2021499A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP06849046A 2005-12-16 2006-12-08 Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz Ceased EP2021499A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75092905P 2005-12-16 2005-12-16
US76205606P 2006-01-24 2006-01-24
US11/636,385 US20070161031A1 (en) 2005-12-16 2006-12-07 Functional arrays for high throughput characterization of gene expression regulatory elements
PCT/US2006/046920 WO2007078599A2 (en) 2005-12-16 2006-12-08 Functional arrays for high throughput characterization of gene expression regulatory elements

Publications (2)

Publication Number Publication Date
EP2021499A2 EP2021499A2 (de) 2009-02-11
EP2021499A4 true EP2021499A4 (de) 2010-02-17

Family

ID=38228711

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06849046A Ceased EP2021499A4 (de) 2005-12-16 2006-12-08 Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz

Country Status (3)

Country Link
EP (1) EP2021499A4 (de)
JP (1) JP2009519710A (de)
WO (1) WO2007078599A2 (de)

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DK2454372T3 (en) 2009-07-15 2019-01-28 Zhenglun Zhu HANDLING OF THE TREATMENT OF INFLAMMATORY OR AUTO-IMMUNE DISEASES USING HOM-1 EXPRESSION
KR20190060881A (ko) 2010-04-23 2019-06-03 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 레베르 선천성 흑내장-1(lca1)의 치료를 위한 재조합 아데노-관련된 바이러스-구아닐레이트 사이클라제 조성물 및 방법
WO2011146411A1 (en) * 2010-05-17 2011-11-24 University Of Southern California Grp78 gene polymorphism rs391957 is associated with tumor recurrence and survival in gastrointestinal cancer patients
DK2661494T3 (da) 2011-01-07 2019-09-02 Applied Genetic Tech Corporation Promotorer, ekspressionskassetter og vektorer til anvendelse ved behandling af achromatopsi og andre sygdomme
EP2835424B1 (de) * 2012-04-03 2019-02-20 National Center For Child Health And Development Mir-140-expression mit dna-steuerung sowie arzneistoff-screeningverfahren mit dieser dna
US9163259B2 (en) 2012-05-04 2015-10-20 Novartis Ag Viral vectors for the treatment of retinal dystrophy
WO2014031079A1 (en) * 2012-08-21 2014-02-27 Singapore Health Services Pte Ltd Method and/or probe for determining glaucoma susceptibility
WO2014159434A1 (en) 2013-03-14 2014-10-02 Monsanto Technology Llc Plant regulatory elements and uses thereof
US9701985B2 (en) 2013-06-04 2017-07-11 Virginia Commonwealth University mda-9/syntenin promoter to image and treat metastatic cancer cells
AU2015208247B2 (en) 2014-01-21 2021-05-27 Universiteit Gent Muscle-specific nucleic acid regulatory elements and methods and use thereof
US20150276767A1 (en) * 2014-03-12 2015-10-01 The University Of Sydney Systems and methods for identifying cancers having activated progesterone receptors
ES2843848T3 (es) 2014-03-21 2021-07-20 Life Technologies Corp Ensayo de referencia para múltiples copias
CN103981185B (zh) * 2014-04-14 2016-04-27 浙江理工大学 肝癌特异性gp73核心启动子及其筛选构建方法
KR101791296B1 (ko) 2014-04-17 2017-10-27 제주대학교 산학협력단 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주
JP6655075B2 (ja) 2014-11-17 2020-02-26 コンテクスト バイオファーマ インコーポレイテッド オナプリストン持続放出組成物および方法
CN104673797B (zh) * 2015-02-09 2018-02-02 苏州大学 参与人体细胞电离辐射应激反应的长链非编码rna及其应用
US10900036B2 (en) 2015-03-17 2021-01-26 The General Hospital Corporation RNA interactome of polycomb repressive complex 1 (PRC1)
US20180187190A1 (en) * 2015-06-12 2018-07-05 Erasmus University Medical Center Rotterdam New crispr assays
JP2018528944A (ja) 2015-09-25 2018-10-04 コンテクスト バイオファーマ インコーポレイテッド オナプリストン中間体の製造方法
AU2016370499B2 (en) 2015-12-15 2022-06-30 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
PE20181922A1 (es) 2016-04-15 2018-12-11 Univ Pennsylvania Terapia genica para tratar la hemofilia a
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
WO2018111104A1 (en) * 2016-12-14 2018-06-21 Erasmus University Medical Center Rotterdam Use of human crispr sequences in diagnostics
EP3600445A1 (de) * 2017-03-27 2020-02-05 Vrije Universiteit Brussel Membranspezifische regulatorische nukleinsäureelemente und verfahren und verwendung davon
AU2018250161B2 (en) * 2017-04-03 2024-04-04 Encoded Therapeutics, Inc. Tissue selective transgene expression
CN114875051A (zh) * 2017-05-31 2022-08-09 北卡罗来纳大学教堂山分校 优化的人凝血因子ix基因表达盒及其应用
RU2671156C1 (ru) * 2017-08-21 2018-10-29 Общество с ограниченной ответственностью "Центр Генетики и Репродуктивной Медицины "ГЕНЕТИКО" Способ преимплантационной генетической диагностики спинальной мышечной атрофии типа 1
WO2019097122A1 (en) * 2017-11-20 2019-05-23 Turun Yliopisto A novel cip2a variant and uses thereof
EP3874065A4 (de) * 2018-10-31 2022-07-20 Rutgers, The State University of New Jersey Gramc: genomskaliges reporterassayverfahren für cis-regulatorische module
FR3088194B1 (fr) * 2018-11-09 2021-02-19 Univ Paris Sud Utilisation du microrna mir-27a-5p pour traiter l'inflammation intestinale induite par clostridium difficile
US20220170110A1 (en) * 2019-04-05 2022-06-02 Korea Advanced Institute Of Science And Technology Cancer diagnostic marker using transposase-accessible chromatin sequencing information about individual, and use thereof
KR102192455B1 (ko) * 2019-04-05 2020-12-17 한국과학기술원 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도
CN110117659B (zh) * 2019-06-18 2022-10-11 上海奕谱生物科技有限公司 一种新型的肿瘤标记物stamp-ep10及其应用
BR112022023410A2 (pt) * 2020-05-19 2022-12-20 Ixaka France Sequências de promotores para expressão in vitro e in vivo de produtos de terapia gênica em células cd3+
MX2022009576A (es) 2020-05-27 2022-09-09 Univ Zuerich Nuevos potenciadores de transduccion y usos de los mismos.
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
CN115698304A (zh) * 2020-10-09 2023-02-03 特纳亚治疗股份有限公司 亲斑蛋白-2基因疗法的方法和组合物
WO2022212766A2 (en) * 2021-03-31 2022-10-06 Hunterian Medicine Llc Compact promoters for gene expression
CN113265428B (zh) * 2021-06-11 2023-03-14 东北林业大学 一种利用金属硫蛋白构建活细胞内铜变化的检测系统及应用
WO2023150553A1 (en) * 2022-02-01 2023-08-10 University Of Rochester Gpr17 promoter-based targeting and transduction of glial progenitor cells
WO2024001172A1 (en) * 2022-06-27 2024-01-04 Ractigen Therapeutics Oligonucleotide modulators activating complement factor h expression

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COOPER SARA J ET AL: "Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.", GENOME RESEARCH JAN 2006, vol. 16, no. 1, 12 December 2005 (2005-12-12), pages 1 - 10, XP009126140, ISSN: 1088-9051 *
ENCODE PROJECT CONSORTIUM: "The ENCODE (ENCyclopedia Of DNA Elements) Project.", SCIENCE (NEW YORK, N.Y.) 22 OCT 2004, vol. 306, no. 5696, 22 October 2004 (2004-10-22), pages 636 - 640, XP009126138, ISSN: 1095-9203 *
KIM TAE HOON ET AL: "Direct isolation and identification of promoters in the human genome.", GENOME RESEARCH JUN 2005, vol. 15, no. 6, June 2005 (2005-06-01), pages 830 - 839, XP002412922, ISSN: 1088-9051 *
TRINKLEIN NATHAN D ET AL: "An abundance of bidirectional promoters in the human genome.", GENOME RESEARCH, vol. 14, no. 1, January 2004 (2004-01-01), pages 62 - 66, XP009126141, ISSN: 1088-9051 *
TRINKLEIN NATHAN D ET AL: "Identification and functional analysis of human transcriptional promoters.", GENOME RESEARCH FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 308 - 312, XP009126139, ISSN: 1088-9051 *
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Also Published As

Publication number Publication date
WO2007078599A8 (en) 2008-10-30
WO2007078599A9 (en) 2007-10-04
EP2021499A2 (de) 2009-02-11
WO2007078599A3 (en) 2008-08-28
JP2009519710A (ja) 2009-05-21
WO2007078599A2 (en) 2007-07-12

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