EP2021499A4 - Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique - Google Patents
Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression geniqueInfo
- Publication number
- EP2021499A4 EP2021499A4 EP06849046A EP06849046A EP2021499A4 EP 2021499 A4 EP2021499 A4 EP 2021499A4 EP 06849046 A EP06849046 A EP 06849046A EP 06849046 A EP06849046 A EP 06849046A EP 2021499 A4 EP2021499 A4 EP 2021499A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gene expression
- high throughput
- regulatory elements
- expression regulatory
- throughput characterization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75092905P | 2005-12-16 | 2005-12-16 | |
US76205606P | 2006-01-24 | 2006-01-24 | |
US11/636,385 US20070161031A1 (en) | 2005-12-16 | 2006-12-07 | Functional arrays for high throughput characterization of gene expression regulatory elements |
PCT/US2006/046920 WO2007078599A2 (fr) | 2005-12-16 | 2006-12-08 | Réseaux fonctionnels pour la caractérisation à grande cadence d'éléments régulant l'expression génique |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2021499A2 EP2021499A2 (fr) | 2009-02-11 |
EP2021499A4 true EP2021499A4 (fr) | 2010-02-17 |
Family
ID=38228711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06849046A Ceased EP2021499A4 (fr) | 2005-12-16 | 2006-12-08 | Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2021499A4 (fr) |
JP (1) | JP2009519710A (fr) |
WO (1) | WO2007078599A2 (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
US8741865B2 (en) | 2009-07-15 | 2014-06-03 | Zhenglun Zhu | Treatment of immune disorders with Hom-1 inhibitors |
TR201901377T4 (tr) | 2010-04-23 | 2019-02-21 | Univ Florida | Leber konjenital amorozisi-1'i (LCA1) tedavi etmek için rAAV-guanilat siklaz bileşimleri ve yöntemler. |
WO2011146411A1 (fr) * | 2010-05-17 | 2011-11-24 | University Of Southern California | Le polymorphisme du gène grp78 rs391957 est associé à une récurrence de tumeur et à la survie chez des patients atteints de cancer gastro-intestinal |
DK2661494T3 (da) * | 2011-01-07 | 2019-09-02 | Applied Genetic Tech Corporation | Promotorer, ekspressionskassetter og vektorer til anvendelse ved behandling af achromatopsi og andre sygdomme |
JP6482869B2 (ja) | 2012-04-03 | 2019-03-13 | 国立研究開発法人国立成育医療研究センター | miR−140の発現を制御するDNA及び該DNAを利用した薬剤のスクリーニング方法 |
US9163259B2 (en) | 2012-05-04 | 2015-10-20 | Novartis Ag | Viral vectors for the treatment of retinal dystrophy |
WO2014031079A1 (fr) * | 2012-08-21 | 2014-02-27 | Singapore Health Services Pte Ltd | Méthode et/ou sonde pour déterminer une sensibilité au glaucome |
EP3575308A1 (fr) | 2013-03-14 | 2019-12-04 | Monsanto Technology LLC | Éléments de régulation des plantes et leurs utilisations |
WO2014197586A1 (fr) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Promoteur du gène de la synténine (mda-9) utilisé pour la prise d'image et le traitement de cellules cancéreuses métastatiques |
US11072801B2 (en) | 2014-01-21 | 2021-07-27 | Vrije Universiteit Brussel | Muscle-specific nucleic acid regulatory elements and methods and use thereof |
US20150276767A1 (en) * | 2014-03-12 | 2015-10-01 | The University Of Sydney | Systems and methods for identifying cancers having activated progesterone receptors |
US11008621B2 (en) | 2014-03-21 | 2021-05-18 | Life Technologies Corporation | Multi-copy reference assay |
CN103981185B (zh) * | 2014-04-14 | 2016-04-27 | 浙江理工大学 | 肝癌特异性gp73核心启动子及其筛选构建方法 |
KR101791296B1 (ko) | 2014-04-17 | 2017-10-27 | 제주대학교 산학협력단 | 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주 |
KR20170084086A (ko) | 2014-11-17 | 2017-07-19 | 아르노 테라퓨틱스 인코포레이티드 | 오나프리스톤 연장-방출 조성물 및 방법 |
CN104673797B (zh) * | 2015-02-09 | 2018-02-02 | 苏州大学 | 参与人体细胞电离辐射应激反应的长链非编码rna及其应用 |
WO2016149455A2 (fr) * | 2015-03-17 | 2016-09-22 | The General Hospital Corporation | Interactome arn de complexe répressif polycomb 1 (prc1) |
WO2016200263A1 (fr) * | 2015-06-12 | 2016-12-15 | Erasmus University Medical Center Rotterdam | Nouveaux dosages crispr |
EP3353148A4 (fr) | 2015-09-25 | 2019-04-24 | Context Biopharma Inc. | Procédés de fabrication d'intermédiaires d'onapristone |
KR20180113988A (ko) | 2015-12-15 | 2018-10-17 | 컨텍스트 바이오파마 인코포레이티드 | 비정질 오나프리스톤 조성물 및 그 제조방법 |
MX2018012537A (es) | 2016-04-15 | 2019-02-25 | Univ Pennsylvania | Terapia de genes para tratar hemofilia a. |
WO2018102369A1 (fr) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Procédés de déshydratation et de déprotection de synthèse d'onapristone |
WO2018111104A1 (fr) * | 2016-12-14 | 2018-06-21 | Erasmus University Medical Center Rotterdam | Utilisation de séquences crispr humaines dans des diagnostics |
US11920149B2 (en) | 2017-03-27 | 2024-03-05 | Vrije Universiteit Brussel | Diaphragm-specific nucleic acid regulatory elements and methods and use thereof |
MX2019011772A (es) * | 2017-04-03 | 2020-01-09 | Encoded Therapeutics Inc | Expresion transgenica selectiva de tejidos. |
KR102625470B1 (ko) | 2017-05-31 | 2024-01-16 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 최적화된 인간 응고 인자 ix 유전자 발현 카세트 및 이의 사용 |
RU2671156C1 (ru) * | 2017-08-21 | 2018-10-29 | Общество с ограниченной ответственностью "Центр Генетики и Репродуктивной Медицины "ГЕНЕТИКО" | Способ преимплантационной генетической диагностики спинальной мышечной атрофии типа 1 |
JP7150018B2 (ja) * | 2017-11-20 | 2022-10-07 | トゥルン イリオピスト | 新規なcip2aバリアント及びその使用 |
US20220017895A1 (en) * | 2018-10-31 | 2022-01-20 | Rutgers, The State University Of New Jersey | Gramc: genome-scale reporter assay method for cis-regulatory modules |
FR3088194B1 (fr) * | 2018-11-09 | 2021-02-19 | Univ Paris Sud | Utilisation du microrna mir-27a-5p pour traiter l'inflammation intestinale induite par clostridium difficile |
US20220170110A1 (en) * | 2019-04-05 | 2022-06-02 | Korea Advanced Institute Of Science And Technology | Cancer diagnostic marker using transposase-accessible chromatin sequencing information about individual, and use thereof |
KR102192455B1 (ko) * | 2019-04-05 | 2020-12-17 | 한국과학기술원 | 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도 |
CN110117659B (zh) * | 2019-06-18 | 2022-10-11 | 上海奕谱生物科技有限公司 | 一种新型的肿瘤标记物stamp-ep10及其应用 |
CN115803438A (zh) * | 2020-05-19 | 2023-03-14 | 艾夏卡法国有限公司 | 用于cd3+细胞体外和体内表达基因治疗产物的启动子序列 |
JP2023527622A (ja) | 2020-05-27 | 2023-06-30 | ウニヴェルジテート・チューリッヒ | 新規形質導入エンハンサーおよびその使用 |
US11781156B2 (en) | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
CA3193067A1 (fr) * | 2020-10-09 | 2022-04-14 | Zhihong Jane YANG | Procedes et compositions de therapie genique basee sur la plakophiline 2 |
WO2022212766A2 (fr) * | 2021-03-31 | 2022-10-06 | Hunterian Medicine Llc | Promoteurs compacts pour l'expression génique |
CN113265428B (zh) * | 2021-06-11 | 2023-03-14 | 东北林业大学 | 一种利用金属硫蛋白构建活细胞内铜变化的检测系统及应用 |
WO2023150553A1 (fr) * | 2022-02-01 | 2023-08-10 | University Of Rochester | Ciblage et transduction basés sur un promoteur rcpg17 de cellules progénitrices gliales |
WO2024001172A1 (fr) * | 2022-06-27 | 2024-01-04 | Ractigen Therapeutics | Modulateurs oligonucléotidiques activant l'expression du facteur h du complément |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6242211B1 (en) * | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US6504084B1 (en) * | 1999-04-23 | 2003-01-07 | Pioneer Hi-Bred International, Inc. | Maize NPR1 polynucleotides and methods of use |
US20030211481A1 (en) * | 2002-05-08 | 2003-11-13 | Erives Albert J. | Method for identifying cellular targets |
-
2006
- 2006-12-08 EP EP06849046A patent/EP2021499A4/fr not_active Ceased
- 2006-12-08 WO PCT/US2006/046920 patent/WO2007078599A2/fr active Application Filing
- 2006-12-08 JP JP2008545677A patent/JP2009519710A/ja not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Non-Patent Citations (6)
Title |
---|
COOPER SARA J ET AL: "Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.", GENOME RESEARCH JAN 2006, vol. 16, no. 1, 12 December 2005 (2005-12-12), pages 1 - 10, XP009126140, ISSN: 1088-9051 * |
ENCODE PROJECT CONSORTIUM: "The ENCODE (ENCyclopedia Of DNA Elements) Project.", SCIENCE (NEW YORK, N.Y.) 22 OCT 2004, vol. 306, no. 5696, 22 October 2004 (2004-10-22), pages 636 - 640, XP009126138, ISSN: 1095-9203 * |
KIM TAE HOON ET AL: "Direct isolation and identification of promoters in the human genome.", GENOME RESEARCH JUN 2005, vol. 15, no. 6, June 2005 (2005-06-01), pages 830 - 839, XP002412922, ISSN: 1088-9051 * |
TRINKLEIN NATHAN D ET AL: "An abundance of bidirectional promoters in the human genome.", GENOME RESEARCH, vol. 14, no. 1, January 2004 (2004-01-01), pages 62 - 66, XP009126141, ISSN: 1088-9051 * |
TRINKLEIN NATHAN D ET AL: "Identification and functional analysis of human transcriptional promoters.", GENOME RESEARCH FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 308 - 312, XP009126139, ISSN: 1088-9051 * |
WILSON V S ET AL: "A NOVEL CELL LINE, MDA-KB2, THAT STABLY EXPRESSES AN ANDROGEN- AND GLUCOCORTICOID-RESPONSIVE REPORTER FOR THE DETECTION OF HORMONE RECEPTOR AGONISTS AND ANTAGONISTS", TOXICOLOGICAL SCIENCES, ACADEMIC PRESS, SAN DIEGO, FL, US, vol. 66, no. 1, 1 March 2002 (2002-03-01), pages 69 - 81, XP009028294, ISSN: 1096-6080 * |
Also Published As
Publication number | Publication date |
---|---|
JP2009519710A (ja) | 2009-05-21 |
WO2007078599A3 (fr) | 2008-08-28 |
EP2021499A2 (fr) | 2009-02-11 |
WO2007078599A2 (fr) | 2007-07-12 |
WO2007078599A8 (fr) | 2008-10-30 |
WO2007078599A9 (fr) | 2007-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2021499A4 (fr) | Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique | |
IL238895A0 (en) | High-throughput sequencing of genomes on DNA arrays | |
EP2135080A4 (fr) | Reseaux fonctionnels pour la caracterisation de traitement d'elements de regulation dans des regions non traduites de genes | |
SG10201405158QA (en) | High throughput genome sequencing on dna arrays | |
HK1216764A1 (zh) | 用於核酸高通量測序的裝置 | |
IL226772A0 (en) | methods@לבקרא@של@ביטוי@גן@במיטרות@עבורת@ב–@ta–sirna | |
HK1217736A1 (zh) | 擴展取得高流量核酸排序 | |
IL187679A (en) | Vector gardens | |
GB0512707D0 (en) | Gene expression technique | |
ZA200709897B (en) | Improved methods controlling gene expression | |
EP1846567A4 (fr) | Microréseaux cellulaires pour le criblage de facteurs de différenciation | |
EP1889902A4 (fr) | Procédé de transformation utilisant le gène mutant de l' acétolactate synthase | |
EP1806393A4 (fr) | Microréacteur pour test génétique | |
HK1124888A1 (zh) | 用於核酸測試的對照 | |
EP1887893A4 (fr) | Farine de grain entier stabilisee | |
SG10201510613QA (en) | Integrated steerability array arrangement for minimizing non-uniformity | |
EP1883291A4 (fr) | Gene assurant une teneur elevee en proteines de cereales | |
HK1125407A1 (en) | Dna constructs for specific inhibition of gene expression by rna interference rna dna | |
GB0514678D0 (en) | Method for high-throughput screening | |
EP2035455A4 (fr) | Procedes de criblage a haut debit de lignees cellulaires | |
EP1714144A4 (fr) | Procede a grande rendement pour la recherche systematique des compositions des carburants | |
EP1731608A4 (fr) | Gene marqueur pour examen d'arthrorhumatisme | |
IL189739A0 (en) | System for screening cells for high expression of a protein | |
EP1967585A4 (fr) | Procede pour l'amplification de genes | |
GB0525523D0 (en) | Genetic process |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20080715 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20100115 |
|
17Q | First examination report despatched |
Effective date: 20100421 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R003 |
|
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20120618 |