JP7396798B2 - 腸内酪酸産生促進用組成物 - Google Patents
腸内酪酸産生促進用組成物 Download PDFInfo
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Images
Description
特許文献1には、イヌリンとスルホニル尿素等とを組み合わせた糖尿病治療のための相乗作用組成物が開示されている。
本発明は、腸内の酪酸産生を促進するための組成物及びそれを含む飲食品又は医薬品を提供することを目的とする。
[2][1]に記載の組成物を含む、飲食品。
[3][1]に記載の組成物を含む、医薬品。
試料として、セルロース(試料名称を「Cell」とする)3g、イヌリン(試料名称を「IQ」とする)3g、セルロース1.5g及びイヌリン1.5g(同様に「Cell+IQ」とする)を調製した。セルロースは富士フイルム和光純薬から購入し、イヌリンはFrutafit IQ(登録商標)(Sensus社)を使用した。
ヒト大腸内を模した腸内細菌叢を再現するために、豚(4-5月齢)の糞便を用いた人口腸管モデルを採用した。糞便懸濁液は、凍結保存の豚糞便に10倍の生理食塩水を加え混合した後、ストレインバッグ(栄研化学)を用いて濾過したものを使用した。
In vitro腸内発酵試験には、Bio Jr.8培養装置(エイブル)を用いた。蒸留水80mLを加えた培養槽、及び蒸留水100mLにNutrient Broth(DifcoLaboratories)4.8gを溶解させた溶液をそれぞれ121℃、15分間滅菌した。滅菌・放冷後、培養槽へ糞便懸濁液を20mL混和し、一晩培養を行った。培養装置の設定条件は、温度37℃、撹拌子回転数400rpmであった。培養槽内のpHが5.5を下回った場合にはアルカリ溶液(2N 水酸化ナトリウム)が自動的に滴下されるように設定した。また、培養槽内を嫌気状態に保つため、二酸化炭素ガスを充填した。
一晩培養後、Nutrient Brothを溶解させた溶液20mL及び試料を培養槽に添加した。48時間培養後、培養液を採取し、遠心分離することで培養上清を得た。
短鎖脂肪酸の測定には、超高速液体クロマトグラフ(NexeraX2、島津製作所)を用い、分析条件は表1とした。培養上清450uLに0.5N 過塩素酸を1mL添加し、5分間静置した後、遠心分離させ、得られた上清をHPLC前処理フィルターで濾過したものを測定サンプルとした。酪酸の同定は測定サンプルと標準溶液の保持時間の比較によって、定量はピーク面積の比較によって行った。
上記の通り試験を行い、各試料添加群の培養液中酪酸量を測定したところ、図1及び表2の結果が得られた。IQ添加群又はCell添加群と比較して、Cell+IQ添加群では、培養液中酪酸量の有意な増加が認められた。
これらの組み合わせの相乗効果を、以下の計算式により算出した。
〈相乗効果〉=XY/((X/2)+(Y/2))
(式中、Xはセルロース(Cell)単体、Yはイヌリン(IQ)単体の短鎖脂肪酸量であり、XYは各試料を組み合わせて添加した場合の短鎖脂肪酸量である。上記[試料の調製]の通り、XYとX又はYは総食物繊維量を等しくしているため、X又はYは、その単体の短鎖脂肪酸量を1/2にしている)
上記計算式から、Cell+IQ添加群の相乗効果は、表2中の各値より、2.35/((0.57/2)+(0.75/2))にて算出したところ3.6倍となった。よって、Cell+IQにおける相乗効果が確認され、イヌリンとセルロースの組み合わせによって腸内細菌叢からの酪酸産生が促進されたことが示された。
Claims (4)
- チコリ由来のイヌリンであって、その平均鎖長が5~20である前記イヌリンとセルロースとを含む腸内酪酸産生促進用組成物であって、前記組成物におけるイヌリンとセルロースとの重量比が1:3~3:1である、前記組成物(但し、イヌリンと、大豆多糖類由来のセルロースと、を含む腸内酪酸産生促進用組成物を除く)。
- 前記重量比が1:1である、請求項1に記載の腸内酪酸産生促進用組成物。
- 請求項1又は2に記載の組成物を含む、腸内酪酸産生促進用飲食品。
- 請求項1又は2に記載の組成物を含む、腸内酪酸産生促進用医薬品。
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