JP7389111B2 - 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法 - Google Patents

細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法 Download PDF

Info

Publication number
JP7389111B2
JP7389111B2 JP2021510122A JP2021510122A JP7389111B2 JP 7389111 B2 JP7389111 B2 JP 7389111B2 JP 2021510122 A JP2021510122 A JP 2021510122A JP 2021510122 A JP2021510122 A JP 2021510122A JP 7389111 B2 JP7389111 B2 JP 7389111B2
Authority
JP
Japan
Prior art keywords
target
seq
vaginalis
lactobacillus
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021510122A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021534764A5 (https=
JP2021534764A (ja
Inventor
デイモン キトレッジ ゲットマン，
アンジェラ セブリング ハドソン，
ジミーキム ファム，
シャンチュン ワン，
キャロライン クラーク，
Original Assignee
ジェン－プローブ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジェン－プローブ・インコーポレーテッド filed Critical ジェン－プローブ・インコーポレーテッド
Publication of JP2021534764A publication Critical patent/JP2021534764A/ja
Publication of JP2021534764A5 publication Critical patent/JP2021534764A5/ja
Priority to JP2023174127A priority Critical patent/JP2023171960A/ja
Application granted granted Critical
Publication of JP7389111B2 publication Critical patent/JP7389111B2/ja
Priority to JP2025184206A priority patent/JP2026016681A/ja
Priority to JP2025184207A priority patent/JP7839936B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021510122A 2018-08-24 2019-08-23 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法 Active JP7389111B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2023174127A JP2023171960A (ja) 2018-08-24 2023-10-06 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184206A JP2026016681A (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184207A JP7839936B2 (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862722627P 2018-08-24 2018-08-24
US62/722,627 2018-08-24
PCT/US2019/047854 WO2020041671A1 (en) 2018-08-24 2019-08-23 Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023174127A Division JP2023171960A (ja) 2018-08-24 2023-10-06 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2021534764A JP2021534764A (ja) 2021-12-16
JP2021534764A5 JP2021534764A5 (https=) 2022-08-18
JP7389111B2 true JP7389111B2 (ja) 2023-11-29

Family

ID=67841311

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2021510122A Active JP7389111B2 (ja) 2018-08-24 2019-08-23 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2023174127A Withdrawn JP2023171960A (ja) 2018-08-24 2023-10-06 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184206A Pending JP2026016681A (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184207A Active JP7839936B2 (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2023174127A Withdrawn JP2023171960A (ja) 2018-08-24 2023-10-06 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184206A Pending JP2026016681A (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
JP2025184207A Active JP7839936B2 (ja) 2018-08-24 2025-10-31 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法

Country Status (6)

Country Link
US (3) US12291753B2 (https=)
EP (1) EP3841222A1 (https=)
JP (4) JP7389111B2 (https=)
KR (3) KR102868953B1 (https=)
AU (1) AU2019324196B2 (https=)
WO (1) WO2020041671A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10550438B2 (en) * 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
US20220205020A1 (en) * 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
CN117288944A (zh) * 2023-09-20 2023-12-26 天津鸿蒙医学研究有限公司 一种阴道加德纳菌的化学发光检测试剂盒及其使用方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103274A1 (en) 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
CN103184289A (zh) 2013-03-30 2013-07-03 江南大学 荧光定量pcr检测醋醅中五种菌的方法
CN104911275A (zh) 2015-07-13 2015-09-16 徐晶 一种细菌性阴道炎检测试剂盒
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis
JP2018508225A (ja) 2015-03-16 2018-03-29 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
WO1988001302A1 (en) 1986-08-11 1988-02-25 Siska Diagnostics, Inc. Nucleic acid probe assay methods and compositions
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
DE3854029T2 (de) 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5516663A (en) 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する２′修飾オリゴヌクレオチド
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
KR100249110B1 (ko) 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
JPH10500310A (ja) 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
EP0975807B1 (en) 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
CA2957197C (en) 2004-08-27 2017-12-12 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US20060194240A1 (en) 2005-02-28 2006-08-31 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US9970060B2 (en) * 2011-11-23 2018-05-15 Medical Diagnostic Laboratories, Llc Quantitation and profiling of vaginal microflora
CN103045725A (zh) * 2012-10-31 2013-04-17 江南大学 一种同时检测醋醅中四种功能微生物的多重pcr技术

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103274A1 (en) 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
CN103184289A (zh) 2013-03-30 2013-07-03 江南大学 荧光定量pcr检测醋醅中五种菌的方法
JP2018508225A (ja) 2015-03-16 2018-03-29 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis
CN104911275A (zh) 2015-07-13 2015-09-16 徐晶 一种细菌性阴道炎检测试剂盒

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BMC Microbiology，2007年，7:115
European Journal of Clinical Microbiology and Infectious Diseases，2015年，34，1779-1785

Also Published As

Publication number Publication date
JP2023171960A (ja) 2023-12-05
KR20250151588A (ko) 2025-10-21
US20250163523A1 (en) 2025-05-22
KR20210063347A (ko) 2021-06-01
US20260117314A1 (en) 2026-04-30
AU2019324196B2 (en) 2025-07-10
US12291753B2 (en) 2025-05-06
CA3108906A1 (en) 2020-02-27
JP2026016682A (ja) 2026-02-03
KR20260040117A (ko) 2026-03-23
JP7839936B2 (ja) 2026-04-02
KR102937202B1 (ko) 2026-03-11
EP3841222A1 (en) 2021-06-30
JP2021534764A (ja) 2021-12-16
JP2026016681A (ja) 2026-02-03
WO2020041671A1 (en) 2020-02-27
AU2019324196A1 (en) 2021-03-18
US20210198720A1 (en) 2021-07-01
KR102868953B1 (ko) 2025-10-13

Similar Documents

Publication Publication Date Title
US12031187B2 (en) Kits for detecting bacterial nucleic acid
JP7839936B2 (ja) 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
US10865433B2 (en) Reaction mixtures for diagnosing bacterial vaginosis
CA3108906C (en) Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
HK40054528A (en) Kits for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
HK40054528B (en) Kits for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220809

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220809

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230726

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230804

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231006

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20231020

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20231116

R150 Certificate of patent or registration of utility model

Ref document number: 7389111

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150