KR102868953B1 - 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법 - Google Patents

세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

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KR102868953B1
KR102868953B1 KR1020217008802A KR20217008802A KR102868953B1 KR 102868953 B1 KR102868953 B1 KR 102868953B1 KR 1020217008802 A KR1020217008802 A KR 1020217008802A KR 20217008802 A KR20217008802 A KR 20217008802A KR 102868953 B1 KR102868953 B1 KR 102868953B1
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target
specific
sequence
seq
lactobacillus
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데이먼 킷트릿지 겟맨
안젤라 세브링 허드슨
지미킴 팜
시안쿤 왕
캐롤린 클락
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젠-프로브 인코포레이티드
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020217008802A 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법 Active KR102868953B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257033007A KR102937202B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862722627P 2018-08-24 2018-08-24
US62/722,627 2018-08-24
PCT/US2019/047854 WO2020041671A1 (en) 2018-08-24 2019-08-23 Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257033007A Division KR102937202B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Publications (2)

Publication Number Publication Date
KR20210063347A KR20210063347A (ko) 2021-06-01
KR102868953B1 true KR102868953B1 (ko) 2025-10-13

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KR1020217008802A Active KR102868953B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020267006922A Pending KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020257033007A Active KR102937202B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Family Applications After (2)

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KR1020267006922A Pending KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020257033007A Active KR102937202B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Country Status (6)

Country Link
US (3) US12291753B2 (https=)
EP (1) EP3841222A1 (https=)
JP (4) JP7389111B2 (https=)
KR (3) KR102868953B1 (https=)
AU (1) AU2019324196B2 (https=)
WO (1) WO2020041671A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10550438B2 (en) * 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
US20220205020A1 (en) * 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
CN117288944A (zh) * 2023-09-20 2023-12-26 天津鸿蒙医学研究有限公司 一种阴道加德纳菌的化学发光检测试剂盒及其使用方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
WO1988001302A1 (en) 1986-08-11 1988-02-25 Siska Diagnostics, Inc. Nucleic acid probe assay methods and compositions
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
DE3854029T2 (de) 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5516663A (en) 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する2′修飾オリゴヌクレオチド
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
KR100249110B1 (ko) 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
JPH10500310A (ja) 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのpna プローブ
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
EP0975807B1 (en) 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
CA2957197C (en) 2004-08-27 2017-12-12 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US20060194240A1 (en) 2005-02-28 2006-08-31 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
EP3040425B1 (en) * 2010-02-17 2019-08-28 Gen-Probe Incorporated Compostions and methods to detect atopobium vaginae nucleic acid
US9970060B2 (en) * 2011-11-23 2018-05-15 Medical Diagnostic Laboratories, Llc Quantitation and profiling of vaginal microflora
CN103045725A (zh) * 2012-10-31 2013-04-17 江南大学 一种同时检测醋醅中四种功能微生物的多重pcr技术
CN103184289A (zh) 2013-03-30 2013-07-03 江南大学 荧光定量pcr检测醋醅中五种菌的方法
US10550438B2 (en) 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
CN106350581B (zh) 2015-07-13 2020-09-18 山东朱氏药业集团有限公司 一种采用检测试剂盒对细菌性阴道炎进行检测的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis

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JP2023171960A (ja) 2023-12-05
KR20250151588A (ko) 2025-10-21
US20250163523A1 (en) 2025-05-22
KR20210063347A (ko) 2021-06-01
US20260117314A1 (en) 2026-04-30
AU2019324196B2 (en) 2025-07-10
US12291753B2 (en) 2025-05-06
CA3108906A1 (en) 2020-02-27
JP2026016682A (ja) 2026-02-03
KR20260040117A (ko) 2026-03-23
JP7839936B2 (ja) 2026-04-02
KR102937202B1 (ko) 2026-03-11
EP3841222A1 (en) 2021-06-30
JP2021534764A (ja) 2021-12-16
JP7389111B2 (ja) 2023-11-29
JP2026016681A (ja) 2026-02-03
WO2020041671A1 (en) 2020-02-27
AU2019324196A1 (en) 2021-03-18
US20210198720A1 (en) 2021-07-01

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