JP7383012B2 - ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 - Google Patents

ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 Download PDF

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Publication number
JP7383012B2
JP7383012B2 JP2021510446A JP2021510446A JP7383012B2 JP 7383012 B2 JP7383012 B2 JP 7383012B2 JP 2021510446 A JP2021510446 A JP 2021510446A JP 2021510446 A JP2021510446 A JP 2021510446A JP 7383012 B2 JP7383012 B2 JP 7383012B2
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optionally substituted
alkyl
methyl
sulfonamide
formula
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JP2021535137A (ja
JP2021535137A5 (https=
JPWO2020047312A5 (https=
Inventor
ティーロ フォッケン，
ジーン－クリストフ アンドレス，
クリステン ニコル バーフォード，
クリストフ マーティン デーンハルト，
マイケル エドワード グリムウッド，
チー ジア，
ヴァーナー アレクサンダー ロフストランド，
スティーブン シグムンド ウェソロウスキー，
マイケル スコット ウィルソン，
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2021510446A 2018-08-31 2019-08-29 ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 Active JP7383012B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862725960P 2018-08-31 2018-08-31
US62/725,960 2018-08-31
PCT/US2019/048900 WO2020047312A1 (en) 2018-08-31 2019-08-29 Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors

Publications (4)

Publication Number Publication Date
JP2021535137A JP2021535137A (ja) 2021-12-16
JP2021535137A5 JP2021535137A5 (https=) 2022-07-20
JPWO2020047312A5 JPWO2020047312A5 (https=) 2022-07-20
JP7383012B2 true JP7383012B2 (ja) 2023-11-17

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Country Status (7)

Country Link
US (1) US10752623B2 (https=)
EP (1) EP3844158A1 (https=)
JP (1) JP7383012B2 (https=)
CN (1) CN112638898B (https=)
CA (1) CA3104913A1 (https=)
MA (1) MA53488A (https=)
WO (1) WO2020047312A1 (https=)

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PL3458449T3 (pl) 2016-05-20 2025-06-23 Xenon Pharmaceuticals Inc. Związki benzenosulfonamidowe i ich zastosowanie jako środki terapeutyczne
CN110325531B (zh) 2016-12-09 2022-05-27 泽农医药公司 苯磺酰胺及其作为治疗剂的用途
US10745392B2 (en) 2018-06-13 2020-08-18 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
KR20210054510A (ko) 2018-08-31 2021-05-13 제논 파마슈티칼스 인크. 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도
US20250034108A1 (en) * 2023-07-07 2025-01-30 Novartis Ag Sodium channel blockers
CN117510431A (zh) * 2023-11-08 2024-02-06 浙江雅辰药物科技股份有限公司 一种异噻唑-3-酮及其衍生物、合成方法

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Also Published As

Publication number Publication date
JP2021535137A (ja) 2021-12-16
CN112638898A (zh) 2021-04-09
MA53488A (fr) 2021-12-08
US20200071313A1 (en) 2020-03-05
US10752623B2 (en) 2020-08-25
CN112638898B (zh) 2024-04-09
EP3844158A1 (en) 2021-07-07
WO2020047312A1 (en) 2020-03-05
CA3104913A1 (en) 2020-03-05

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